Radical cross-coupling has emerged as a powerful strategy for facilitating the construction of complex
molecular architectures from simple and readily available building blocks. Advances in nickel electrocatalysis
have expanded this reactivity to the efficient assembly of medicinally relevant structures, including PROTAC
scaffolds and highly substituted small rings.1,2
More recently, hydrazide-based precursors have challenged a long-standing paradigm in radical chemistry:
“freely generated carbon-centered radicals lose their chiral information on the picosecond timescale (10–12 s)”,
making enantioretentive intermolecular radical cross-coupling exceptionally challenging. These radical
precursors can transfer stereochemical information from chiral starting materials into newly formed C–C bonds
with high fidelity.3-4 This discovery opens new opportunities to harness the power and simplicity of radical
chemistry for the streamlined synthesis of enantioenriched molecules.
29 ottobre 2026
Dott. Luca Massaro
Department of Chemistry, KTH Royal Institute of Technology,
Teknikringen 30, S-10044 Stockholm, Sweden
will deliver a seminar titled:
Frontiers in Radical Cross-Coupling: Electrocatalysis, Stereoretentive Transformations, and Applications in Drug Synthesis
Giovedì 29 ottobre 2026 14:30
Aula Seminari (Aula Lorenzo Stella)
Dipartimento di Scienze e Tecnologie Chimiche