2025
1) Patrizi S, Vallese S, Barresi S, Cassandri M, Giovannoni I, Pedace L, Abballe L, Vinciarelli F, Antonacci C, Stracuzzi A, Mancini B, Russo I, Di Giannatale A, Rota R, Alaggio R, Locatelli F, Milano GM, Miele E. Age-linked DNA methylation and gene expression patterns in parameningeal head and neck alveolar rhabdomyosarcoma reveal CDK9 as a promising therapeutic target. Pharmacol Res. 216:107767 (2025).
2) Antonacci C, Abballe L, Patrizi S, Pedace L, Barresi S, Giovannoni I, Tancredi C, Vinciarelli F, Megaro G, Carai A, Rossi S, Locatelli F, Mastronuzzi A, Miele E. DNA methylation profiling from cerebrospinal fluid as a diagnostic tool for pineoblastoma. Acta Neuropathol Commun. 8;13(1):52. (2025)
3) Monetta R, Campagna D, Bartolocci V, Capone A, Teson M, Filippi S, Gabellone S, Piccinino D, Saladino R, Dellambra E. Differential Effects of Biomimetic Thymine Dimers and Corresponding Photo-Adducts in Primary Human Keratinocytes and Fibroblasts. Biomolecules. 2024 Nov 21;14(12):1484.
4) BXia,FXu,JChen,SShan,JShen,YZhang,JWang,ZZhou,WSun,YJia, Y-L Zhang, J Zhong, G Zhang, Y Wan, Z Hu, Y Fan, M Bottini, J Wang, X J Liang. Site-specific adaptive nanovesicles for oral insulin delivery. Science Advances, 11(2025): eady6386.
5) X Gong, S Liu, B Xia, Y Wan, S Zhang, B Zhang, Z Wang, J Chen, F Xiao, X-J Liang. Oral delivery of therapeutic proteins by engineered bacterial type zero secretion system. Nature Communications, 16(2025), 1862.
6) Giacobbi E, Scioli MP, Servadei F, Palumbo V, Bonfiglio R, Bove P, Mauriello A, Scimeca M. PAX Family, Master Regulator in Cancer. Diagnostics (Basel). 2025 Jun 3;15(11):1420.
7) Scimeca M, Giacobbi E, Bonfiglio R, Sisto R, Casciardi S, Servadei F, Middleton DRS, Bischof J, Scioli MP, Modesti G, Candi E, Melino G, Mauriello A. Lead bioaccumulation in human breast cancer tissue is associated with DNA instability and cell death resistance. Cell Death Discovery. 2025 Aug 15;11(1):383.
8) Foffi E, Violante A, Pecorari R, Lena AM, Rugolo F, Melino G, Candi E. BRD4 sustains p63 transcriptional program in keratinocytes. Biol. Direct. 19, 124 (2024).
9) Amorini AM, Mangione R, Cirnigliaro L, Saab MW, Pettinato F, Barbato A, Distefano A, La Spina E, Lazzarino G, Li Volti G, Longhitano L, Tibullo D, Pittalà A, Giallongo C, Di Pietro V, Tabbi G, Graziani A, Tavazzi B,Lazzarino G, Barone R. Targeted metabolomic evaluation of peripheral blood mononucleated cells from patients with PMM2-CDG. Molecular Genetics and Metabolism. 15, 15929 (2024)
10) Barnaba D*, Franzese Canonico M*, Helmer-Citterich M, Gandellini P, Melino G, Smirnov A, Candi E. LEADR, a p63 target, dampens interferon signalling in bladder cancer. Cell Death Discov. 2025 Jun 3;11(1):264
11) Pecorari R, Mancini M, Smirnov A, Corleone G, Novelli F, Lena AM, Franzese Canonico M, et al. p63 and ZNF148 cooperate to regulate head and neck squamous cell carcinoma. Proc Natl Acad Sci USA. 2025 Jul 15;122(28):e2500579122
12) Bruno V, Zizolfi B, Ferretti M, Di Martino S, Arteni Brindusa AM, Betti M, Ciuffreda L, De Nicola F, Scalera S, Cariati F, De Angelis C, Nardelli F, Giudice M, Mancini E, Baiocco E, Russo M, Pallocca M, Fanciulli M, Piaggio G, Carosi M, Di Spiezio Sardo A, Vizza E. Hystero-embryoscopy as a tool for RPL immunological research at the maternal-fetal interface. Placenta. 2025 Aug;168:28-34.
13) Ronchetti L, Terrenato I, Lobascio AM, Iacobelli M, Ferretti M, Setti Boubaker N, Sperati F, Mandoj C, Mancini E, Carosi M, Vizza E, Corrado G. Role of inflammatory blood parameters from complete blood count in predicting ovarian follicular density in cancer patients undergoing ovarian tissue cryopreservation. J Ovarian Res. 2025 Apr 30;18(1):89.
14) De Domenico S, La Banca V, D'Amico S, Nicolai S and Peschiaroli A. Defining the transcriptional routes controlling lncRNA NEAT1 expression: implications in cellular stress response, inflammation, and differentiation. Discov Oncol. 15;16(1):768. (2025).
15) Russo B, D’Addato G, Salvatore G, Menduni M, Frontoni S, Carbone L Gliotic Response and Reprogramming Potential of Human Müller Cell Line MIO-M1 Exposed to High Glucose and Glucose Fluctuations. Int J Mol Sci 25:12877 (2024).
16) Puce A, Ferraresi V, Biagini R, Soddu S, Loria R.Three-dimensional preclinical models for Osteosarcoma: Advances and translational prospects. Biomed Pharmacother.191:118471(2025)
17) Blandino G, Satchi-Fainaro R, Tinhofer I, Tonon G, Heilshorn SC, Kwon YJ, Pestana A, Frascolla C, Pompili L, Puce A, Iachettini S, Tocci A, Karkampouna S, Kruithof-de Julio M, Tocci P, Porciello N, Maccaroni K, Rutigliano D, Shen X, Ciliberto G.Cancer Organoids as reliable disease models to drive clinical development of novel therapies. J Exp Clin Cancer Res. 28;43(1):334 (2024).
18) Sica GS, Anania G, Fiorani C, Siragusa L, Vinci D, Caricato M, Delrio P, Agrusa A, Baldazzi G, Reddavid R, Pellino G; RRoC-STAR Collaborative Group. Standardization of the surgical technique and reporting for radical right colectomy with central vascular ligation and complete mesocolic excision (RRoC-STAR): Delphi consensus. BJS Open. 2025 May 7;9(3):zraf066.
19) Melino G, Bischof J, Chen WL, Jia W, Juhl H, Kopeina GS, Mauriello A, Novelli F, Scimeca M, Shi Y, Pirozzi BM, Sica G, Zamaraev AV, Zhivotovsky B. New hope for the world cancer day. Biol Direct. 2025 Feb 4;20(1):14.
20) Lori G, Coppola L, Casella M, Tinari A, Masciola I and Tait S Chlorpyrifos induces autophagy by suppressing the mTOR pathway in immortalized GnRH neurons Chemosphere 362, 142723 (2024).
21) Santangelo C, Scazzocchio B, Varì R, Ajmone-Cat MA, Tammaro A, Tait S, Masciola I, Tassinari R, Vincentini O, Di Benedetto R, Berry A, Cirulli F, Maranghi F, De Simone R and D'Archivio M Insights into the sex-related effects of dietary polyphenols and metabolic disruptors on inflammatory and (neuro)endocrine pathways in obesity: the HEAL project Nutrients 16, 3595 (2024).
22) Lena AM, Smirnov A, Mancini M, Montanaro M, Ciccosanti F, Foti V, Nardacci R, Fimia GM, Mavilio M, Federici M, Mauriello A, Piacentini M, Melino G, Candi E “Deletion of the p63 exon 13 in mice reveals C-terminal isoform-specific functions in epithelial development” PNAS, 122 (29) e2503866122 (2025)
23) Fierro C, Giovannini S, Moriconi V, Fiorilli C, Panatta E, Frezza V, Corigliano F, Pecorari R, Li Y, Zhou J, Delvecchio VS, Smirnov A, Manteiga JMG, Brendolan A, Zhang J, Shi Y, Amelio I, Candi E, Melino G, Bernassola F. The WWP1-JARID1B axis sustains acute myeloid leukemia chemoresistance. Proc Natl Acad Sci USA 122(28) (2025).
24) Scimeca M, Palumbo V, Giacobbi E, Servadei F, Casciardi S, Cornella E, Cerbara F, Rotondaro G, Seghetti C, Scioli MP, Montanaro M, Barillà F, Sisto R, Melino G, Mauriello A, Bonfiglio R Impact of the environmental pollution on cardiovascular diseases: from epidemiological to molecular evidence Heliyon 10, e38047 (2024).
25) Vecchio A, Colasuonno F, Occhigrossi L, Pitolli C, Bellanca V, Ciccarone F, D'Eletto M, Di Sano F, Pagliarini V, Sette C, Piacentini M, Rossin F. Epigenetic modulation of RIPK3 by transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis. Cell. Mol. Life Sci. 82, 154 (2025).
26) Belardi R, Pacifici F, Cosio T, Lambiase S, Shumak RG, Artosi F, Rivieccio A, Cavalloro D, Dellambra E, Bianchi L, Della-Morte D, Campione E. Role of Nicotinamide in the Pathogenesis of Actinic Keratosis: Implications for NAD+/SIRT1 Pathway”; Biomolecules. 2024 Nov 27;14(12):1512. doi: 10.3390/biom14121512.
27) Belardi R, Pacifici F, Baldetti M, Velocci S, Minieri M, Pieri M, Campione E, Della-Morte D, Tisone G, Anselmo A, Novelli G, Bernardini S, Terrinoni A. Trends in Precision Medicine and Pharmacogenetics as an Adjuvant in Establishing a Correct Immunosuppressive Therapy for Kidney Transplant: An Up-to-Date Historical Overview Int J Mol Sci. 2025 Feb 24;26(5):1960.
28) Cortellesi, E., Savini, I., Veneziano, M., Gambacurta, A., Catani, M.V., and Gasperi, V. (2025). Decoding the epigenome of breast cancer. Int. J. Mol. Sci. 26(6), 2605.
29) Marrone, G., Di Lauro, M., Cornali, K., Masci, C., Vanni, G., Vita, C., et al. (2025). Sustainability and role of plant-based diets in chronic kidney disease prevention and treatment. Frontiers in Pharmacology, 16 [10.3389/fphar.2025.1562409]
30) Cornali K, Di Lauro M, Marrone G, Masci C, Montalto G, Giovannelli A, Schievano C, Tesauro M, Pieri M, Bernardini S, et al. The Effects of a Food Supplement, Based on Co-Micronized Palmitoylethanolamide (PEA)–Rutin and Hydroxytyrosol, in Metabolic Syndrome Patients: Preliminary Results. Nutrients. 2025; 17(3):413.
31) Monetta R, Campagna D, Bartolocci V, Capone A, Teson M, Filippi S, Gabellone S, Piccinino D, Saladino R, Dellambra E. “Differential Effects of Biomimetic Thymine Dimers and Corresponding Photo-Adducts in Primary Human Keratinocytes and Fibroblasts”. Biomolecules, 2024 Nov 21;14(12):1484.
32) Battistini B, Lulli D, Bocca B, Carbone M.L., Ramondino C, Caimi S, Capone A, Nicodemi E M, Dellambra E, De Angelis I, Failla C M. “Tattoo Ink Metal Nanoparticles: Assessment of Toxicity In Vitro and with a Novel Human Ex Vivo Model”. Nanomaterials, 2025 Feb 11; 15(4), 270.
33) Barnaba D, Franzese Canonico M, Helmer-Citterich M, Gandellini P, Melino G, Smirnov A, Candi E. LEADR, a p63 target, dampens interferon signalling in bladder cancer. Cell Death Discov. 2025;11(1):264.
2024
1) Pedace L, Pizzi S, Abballe L, Vinci M, Antonacci C, Patrizi S, Nardini C, Del Bufalo F, Rossi S, Pericoli G, Gianno F, Besharat ZM, Tiberi L, Mastronuzzi A, Ferretti E, Tartaglia M, Locatelli F, Ciolfi A, Miele E. Evaluating cell culture reliability in pediatric brain tumor primary cells through DNA methylation profiling. NPJ Precis Oncol. 2024 Apr 18;8(1):92.
2) Lapenta C, Santini SM, Antonacci C, Donati S, Cecchetti S, Frittelli P, Catalano P, Urbani F, Macchia I, Spada M, Vitale S, Michelini Z, Corsi DC, Zeuner A, Dattilo R, Tamburo De Bella M. Anti-Tumor Immunity to Patient-Derived Breast Cancer Cells by Vaccination with Interferon-Alpha-Conditioned Dendritic Cells (IFN-DC). Vaccines (Basel). 2024 Sep 17;12(9):1058.
3) La Banca V, De Domenico S, Nicolai S, Gatti V, Scalera S, Maugeri M, Mauriello A, Montanaro M, Pahnke J, Candi E, D'Amico S, Peschiaroli A. ABCC1 Is a ΔNp63 Target Gene Overexpressed in Squamous Cell Carcinoma. Int J Mol Sci. 2024 Aug 10;25(16):8741.
4) Mangione R, Giallongo C, Duminuco A, La Spina E, Longhitano L, Giallongo S, Tibullo D, Lazzarino G, Saab MW, Sbriglione A, Palumbo GA, Graziani A, Alanazi AM, Di Pietro V, Tavazzi B, Amorini AM, Lazzarino G (2024) Targeted Metabolomics Highlights Dramatic Antioxidant Depletion, Increased Oxidative/Nitrosative Stress and Altered Purine and Pyrimidine Concentrations in Serum of Primary Myelofibrosis Patients. Antioxidants, 13:490.
5) Bonfiglio, R., Sisto, R., Casciardi, S., Palumbo, V., Scioli, M.P., Palumbo, A., Trivigno, D., Giacobbi, E., Servadei, F., et al. The Impact of Toxic Metal Bioaccumulation on Colon Rectal Cancer: Unravelling the Uexplored Connection. Science of the Total Environment 2023.
6) Scimeca M, Palumbo V, Giacobbi E, Servadei F, Casciardi S, Cornella E, Cerbara F, Rotondaro G, Seghetti C, Scioli MP, Montanaro M, Barillà F, Sisto R, Melino G, Mauriello A, Bonfiglio R. Impact of the environmental pollution on cardiovascular diseases: From epidemiological to molecular evidence. Heliyon. 2024 Sep 19;10(18)
7) Giovannini, S., Smirnov, A., Concetti, L., Scimeca, M., Mauriello, A., Bischof, J., Rovella, V., Melino, G., Buonomo, C. O., Candi, E., and Bernassola, F. (2024). A comprehensive molecular characterization of a claudin-low luminal B breast tumor. Biology direct, 19(1), 66. https://doi.org/10.1186/s13062-024-00482-1
8) La Banca V, De Domenico S, Nicolai S, Gatti V, Scalera S, Maugeri M, Mauriello A, Montanaro M, Pahnke J, Candi E, D'Amico S, Peschiaroli A. ABCC1 Is a ΔNp63 Target Gene Overexpressed in Squamous Cell Carcinoma. Int J Mol Sci. 2024 Aug 10;25(16):8741.
9) Bonfiglio R, Sisto R, Casciardi S, Palumbo V, Scioli MP, Giacobbi E, Servadei F, Melino G, Mauriello A, Scimeca M. Aluminium bioaccumulation in colon cancer, impinging on epithelial-mesenchymal-transition and cell death. Sci Total Environ. 2024 Jan 15;908:168335. doi: 10.1016/j.scitotenv.2023.168335.
10) Smirnov A, Lena AM, Tosetti G, Yang X, Cappello A, Helmer Citterich M, Melino G, Candi E. Epigenetic priming of an epithelial enhancer by p63 and CTCF controls expression of a skin-restricted gene XP33. Cell Death Discov. 2023 Dec 8;9(1):446.
11) Rigon M, Mutti L & Campanella M. (2024). Pleural mesothelioma (PMe): The evolving molecular knowledge of a rare and aggressive cancer. Molecular Oncology. https://doi.org/10.1002/1878-0261.1359
12) Sica, G.S., Siragusa, L., Pirozzi, B.M., ... Bellato, V., Franceschilli, M. Gastrointestinal functions after laparoscopic right colectomy with intracorporeal anastomosis: a pilot randomized clinical trial on effects of abdominal drain, prolonged antibiotic prophylaxis, and D3 lymphadenectomy with complete mesocolic excision International Journal of Colorectal Disease, 2024, 39(1), 102
13) Degiuli M, Aguilar AHR, Solej M, Azzolina D, Marchiori G, ……Pirozzi B, Muratore A, Calabrò M, Jovine E, Lombardi R, Anania G, Chiozza M, Petz W, Pizzini P, Persiani R, Biondi A, Reddavid R. A Randomized Phase III Trial of Complete Mesocolic Excision Compared with Conventional Surgery for Right Colon Cancer: Interim Analysis of a Nationwide Multicenter Study of the Italian Society of Surgical Oncology Colorectal Cancer Network (CoME-in trial) Annals of Surgical Oncology, 2024, 31(3), pp. 1671–1680
14) Corti G, Buchet R, Magrini A, Ciancaglini P, Mebarek S, Bottini M. The surface proteomic profile of serum extracellular vesicles as a diagnostic and prognostic tool in breast cancer. Current Opinion in Physiology. 2024 Jan; 37:100734.
15) Mebarek S, Buchet R, Pikula S, Strzelecka-Kiliszek A, Brizuela L, Corti G, Collacchi F, Anghieri G, Magrini A, Ciancaglini P, Millan JL, Davies O, Bottini M. Do media extracellular vesicles and extracellular vesicles bound to the extracellular matrix represent distinct types of vesicles? Biomolecules. 2024 Jan;14(1):42.
16) Corti G, Kim J, Enguita F, Guarnieri J, Grossman L, Costes S, Fuentealba M, Scott R, Magrini A, Sanders L, Furman D, Calleja-Agius J, Mason C, Galeano D, Bottini M, Beheshti A. To boldly go where no microRNAs have gone before: Spaceflight impact on risk for small-for-gestational-age infants. Communication Biology. 2024 April. doi: 10.21203/rs.3.rs-4003363/v1.
17) Morelli M, Carbone ML, Scaglione GL, Scarponi C, Di Francesco V, Pallotta S, De Galitiis F, Rahimi S, Madonna S, Failla CM, Albanesi C “Identification of immunological patterns characterizing immune-related psoriasis reactions in oncological patients in therapy with anti-PD-1 checkpoint inhibitors.” Front. Immunol. 2024, doi: 10.3389/fimmu.2024.1346687.
18) Giovannini S, Li Y, Pecorari R, Fierro C, Fiorilli C, Corigliano F, Moriconi V, Zhou J, De Antoni A, Smirnov A, Rinalducci S, Timperio AM, Agostini M, Zhang J, Shi J, Candi E, Melino G, Bernassola F. Thioredoxin-interacting protein (TXNIP) is a substrate of the NEDD4-like E3 ubiquitin-protein ligase WWP1 in cellular redox state regulation of acute myeloid leukemia cells. Mol. Oncol. 2024 Oct 4. doi: 10.1002/1878-0261.13722
19) Lori G, Coppola L, Casella M, Tinari A, Masciola I, Tait S Chlorpyrifos induces autophagy by suppressing the mTOR pathway in immortalized GnRH neurons. Chemosphere 2024-08 DOI: 10.1016/j.chemosphere.2024.142723
20) Zhu M, Rovella V, Scimeca M, Mauriello A, Shi Y, Bischof J, Woodsmith J, Melino G, Tisone G, Agostini M Genomic and transcriptomic profiling of hepatocellular carcinoma reveals a rare molecular subtype Discov Oncol. 2024 Jan 16;15(1):10.
2023
1) Abballe, L., Spinello, Z., Antonacci, C., Coppola, L., Miele, E., Catanzaro, G., & Miele, E. (2023). Nanoparticles for Drug and Gene Delivery in Pediatric Brain Tumors' Cancer Stem Cells: Current Knowledge and Future Perspectives. Pharmaceutics, 15(2), 505.
2) Abballe, L., Alfano, V., Antonacci, C., Cefalo, M. G., Cacchione, A., Del Baldo, G., Pezzullo, M., Po, A., Moretti, M., Mastronuzzi, A., De Smaele, E., Ferretti, E., Locatelli, F., & Miele, E. (2023). β-arrestin1-E2F1-ac axis regulates physiological apoptosis and cell cycle exit in cellular models of early postnatal cerebellum. Frontiers in cell and developmental biology, 11, 990711.
3) Gatti, V., De Domenico, S., Melino, G., & Peschiaroli, A. (2023). Senataxin and R-loops homeostasis: multifaced implications in carcinogenesis. Cell Death Discovery, 9(1), 145.
4) Fierro, C., Gatti, V., La Banca, V., De Domenico, S., Scalera, S., Corleone, G., ... & Peschiaroli, A. (2023). The long non-coding RNA NEAT1 is a ΔNp63 target gene modulating epidermal differentiation. Nature Communications, 14(1), 3795.
5) Palumbo, V., Scioli, M.P., Bonfiglio, R., Scimeca, M. (2023). Breast Cancer Metastasis to Bone:
Look into the Future. In: Interdisciplinary Cancer Research. Springer, Cham.
6) Scimeca, M.; Rovella, V.; Palumbo, V.; Scioli, M.P.; Bonfiglio, R.; TOR CENTRE; Melino, G.;
Piacentini, M.; Frati, L.; Agostini, M.; et al. Programmed Cell Death Pathways in
Cholangiocarcinoma: Opportunities for Targeted Therapy. Cancers 2023, 15, 3638.
7) Buonvino, S., Ciocci, M., Nanni, F., Cacciotti, I., Melino, S. New Vegetable-Waste Biomaterials by Lupin Albus L. as Cellular Scaffolds for Applications in Biomedicine and Food. Biomaterials 2023, 293, 121984. Online from December 2022
8) Nurchi, C., Buonvino, S., Arciero, I., Melino, S. Sustainable Vegetable Oil-Based Biomaterials: Synthesis and Biomedical Applications Int. J. Mol. Sci. 2023, 24(3), 2153;
9)Gambacurta, N., Gasperi, V., Guzzo, T., Di Leva, F. S., Ciriaco, F., Sánchez, C., Tullio, V., ... & Maccarrone, M. (2023). Exploring the 1, 3-benzoxazine chemotype for cannabinoid receptor 2 as a promising anti-cancer therapeutic. European Journal of Medicinal Chemistry, 115647.
10) Sica GS, Vinci D, Siragusa L, Sensi B, Guida AM, Bellato V, García-Granero Á, Pellino G. Correction: Definition and reporting of lymphadenectomy and complete mesocolic excision for radical right colectomy: a systematic review. Surg Endosc. 2023 Mar;37(3):2418
11) Sica GS, Vinci D, Siragusa L, Sensi B, Guida AM, Bellato V, García-Granero Á, Pellino G. Definition and reporting of lymphadenectomy and complete mesocolic excision for radical right colectomy: a systematic review. Surg Endosc. 2023 Feb;37(2):846-861. doi: 10.1007/s00464-022-09548-5. Epub 2022 Sep 12. Erratum in: Surg Endosc. 2022 Nov 4
12) Fierro C, Gatti V, La Banca V, De Domenico S, Scalera S, Corleone G , Fanciulli M,
De Nicola F, Mauriello A, Montanaro M, Calin GA, Melino G and Peschiaroli A.The long non-coding RNA NEAT1 is a ΔNp63 target gene modulating epidermal differentiation (2023) Nat. Commun.
13) Scimeca M. Rovella V. Palumbo V. Scioli M.P. Bonfiglio R. TOR CENTRE; Melino, G.; Piacentini, M.; Frati, L. Agostini M. et al. Programmed Cell Death Pathways in Cholangiocarcinoma: Opportunities for Targeted Therapy. Cancers 2023, 15, 3638.
14) Cappello, A., Zuccotti, A., Mancini, M., Tosetti, G., Fania, L., Ricci, F., Melino, G., & Candi, E. (2023). Serine and one-carbon metabolism sustain non-melanoma skin cancer progression. Cell death discovery, 9(1), 102.
15) Montanaro M, Agostini M, Anemona L, Bonanno E, Servadei F, Finazzi Agrò E, Asimakopoulos AD, Ganini C, Cipriani C, Signoretti M, Bove P, Rugolo F, Imperiali B, Melino G, Mauriello A, Scimeca M
ZNF750: a novel prognostic biomarker in metastatic prostate cancer Int. J. Mol. Sci. 2023, 24, 651
16) Liu R, Scimeca M, Sun Q, Melino G, Mauriello A, Shao C, TOR Centre, Shi Y, Piacentini M, Tisone G and Agostini M Harnessing metabolism of hepatic macrophages to aid liver regeneration Cell Death Dis. 2023 Aug 29;14(8):574