The Board of Teachers proposes, the Research Doctorate TISSUE ENGINEERING AND REMODELING BIOTECHNOLOGIES FOR BODY FUNCTION with the aim: - To extend the knowledge both at the molecular and clinical levels on the etiology, pathogenesis and the progress of acquired and/or hereditary diseases, of metabolic, degenerative and/or oncological character, concerning (i) the motility apparatus, (ii) the maxillo-facial district, (iii) the vision system, (iv) the othorinolaringoiatric system from the medical, surgical, sport and rehabilitationary standpoint. - To build up research programs in the biotechnological and biomedical field for their therapeutic and rehabilitative application. This program would be mainly focused toward the investigation on chronic degenerative diseases, which have a fall-up on the health system. Within the Research Doctorate we will also promote research projects for the study of physico-chemical properties of Biomaterials for the regeneration and remodelling of the Extra-Cellular Matrix and for the development of new Biotechnologies in view of their clinical application in different body districts considering the expertise of the members of the College of Teachers. The Board of Teachers of the Doctorate will contribute, due to the multidisciplinarity of expertises, ranging between molecular expertises (Biochemistry, Molecular Biology and Pathology), cellular expertises (Cell Pathology, Tissue and Genetic Engineering), clinical expertises (Biomechanics and Clinics), to the accomplishment of these targets through: - a) the optimization of biotechnological resources in the molecular and cellular field; - b) the creation of bio-banks of epidemiological data; - c) the design and experimentation of innovative systems, pathways and diagnostic protocols. From the organisational standpoint, the Doctorate will be subdivided in four pathways, closely interrelated (through the collaboration of multidisciplinary tutors), namely of (i) molecular pathophysiology, (ii) tissue engineering and remodelling of the Extracellular matrix, (iii) clinical research for the optimization of the body functioning, (iv) therapeutic and rehabilitation application. In particular, the first pathway will be devoted to the analysis and identification of molecular mechanisms underlying different pathologies, mostly addressed toward the head-neck region and the motility apparatus. The second pathway will mainly deal with the features of biomaterials for the development of innovative tissue engineering and Extracellular Matrix remodelling approaches for the exploitation of stem cells in the orthopedic, ophthalmology, and othorinolaringoiatric fields. The third pathway will be mostly dedicated to the deepening of clinical aspects, also employing the knowledge derived from the previous pathways, in the field of orthopedy and the head-neck district for an optimization of body functioning also in the field of Sports Medicine. Finally, the fourth pathway will mostly concern the research on innovative systems for the cure and rehabilitation of these pathologies. Thanks to this interdisciplinary approach each pathology (or disability) will be investigated by the graduate students from different viewpoints, ranging from the molecular pathogenetic mechanisms to the clinical and rehabilitative aspect, guaranteeing a multidisciplinary and translational approach. Obviously, different aspects will be investigated under absolute autonomy from different members of The Board of the Teachers also on the basis of the funding and ongoing research projects.
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