Curriculum vitae
BANO, Daniele, Ph.D.
NAME: Daniele Bano
NATIONALITY: Italian
WORK ADDRESS: Deutsches Zentrum für Neurodegenerative Erkrankungen e. V. (DZNE) in der Helmholtz-Gemeinschaft, Venusberg-Campus 1, Gebäude 99, 53127 Bonn, Germany
TELEPHONE: +49 228 43302510
E-MAIL: daniele.bano@dzne.de
CURRENT POSITION: Research Group Leader (W2) at DZNE, Germany
University training and degree
1998 Degree in Biology, University of Padova, Italy
1990 Advanced academic qualifications
2003 PhD in Biochemistry and Biophysics, University of Padova, Italy
2021 Abilitazione Scientifica Nazionale (ASN) “Biochimica Generale”, fascia I e II
2021 Abilitazione Scientifica Nazionale (ASN) “Biologia Molecolare”, fascia I e II
Postgraduate professional career
2009-present Research Group Leader (W2), DZNE, Bonn, Germany
2008-2009 Programme Leader Track, MRC Toxicology Unit, University of Leicester, Leicester, UK
2007-2008 Postdoc, Institute of Molecular Life Sciences, University of Zurich, Switzerland
2003-2007 Postdoc/ Senior Investigator scientist, MRC Toxicology Unit, University of Leicester, Leicester, UK
Additional experiences
March-Aug 2000 Visiting scientist, University of Konstanz, Konstanz, Germany
Nov 2001-Feb 2003 Visiting scientist, MRC Toxicology Unit, University of Leicester, Leicester, UK
Oct 2003 Visiting scientist, Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, USA
Editor and reviewer activities
Receiving Editor of Cell Death and Disease and ad-hoc editor of other journals.
Invited reviewer of many international peer-reviewed journals.
Scientific fields of research (keywords)
Metabolism; aging; chromatin remodeling; neurodegenerative diseases.
Peer-reviewed publications
1. Vitale I. et al. Apoptotic cell death-Current understanding of the NCCD 2023. Cell Death Differ 2023; doi: 10.1038/s41418-023-01153-w.
2. Xie K, Fuchs H, Scifo E, Liu D, Aziz A, Aguilar-Pimentel JA, Amarie OV, Becker L, da Silva-Buttkus, Calzada-Wack J, Cho YL, Deng Y, Edwards AC, Garrett L, Georgopoulou C, Gerlini R, Hölter SM, Klein-Rodewald T, Kramer M, Leuchtenberger S, Lountzi D, Mayer-Kuckuk P, Nover LL, Oestereicher MA, Overkott C, Pearson BL, Rathkolb B, Rozman J, Russ J, Schaaf K, Spielmann N, Sanz-Moreno A, Stoeger C, Treise I, Bano D, Busch DH, Graw J, Klingenspor M, Klopstock T, Moch BA, Salomoni P, Schmidt-Weber C, Weiergräber M, Wolf E, Wurst W, Gailus-Durner V, Breteler MMB, de Angelis MH, Ehninger D. Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice. Nature Communications 2022; doi:10.1038/s41467-022-34515-y.
3. Wischhof L, Lee HM, Tutas J, Overkott C, Tedt E, Stork M, Peitz M, Brüstle O, Ulas T, Händler K, Schultze JL, Ehninger D, Nicotera P, Salomoni P, Bano D. BCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation. The EMBO Journal 2022; doi: 10.15252/embj.2022110595.
4. Wischhof L, Scifo E, Ehninger D, Bano D. AIFM1 beyond cell death: An overview of this OXPHOS-inducing factor in mitochondrial diseases. EBioMedicine 2022; doi: 10.1016/j.ebiom.2022.104231.
5. Keshavarz M, Xie K, Schaaf K, Bano D, Ehninger D. Targeting the “hallmarks of aging and treat age-related disease: fact or fiction?. Mol Psychiatry 2022; doi: 10.1038/s41380-022-01680-x.
6. Jackson J, Wischhof L, Scifo E, Pellizzer A, Wang Y, Piazzesi A, Gentile D, Siddig S, Stork M, Hopkins CE, Händler K, Weis J, Roos A, Schultze JL, Nicotera P, Ehninger D, Bano D. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Mol Metab 2022; doi:10.1016/j.molmet.2022.101503.
7. Piazzesi A, Wang Y, Jackson J, Wischhof L, Zeisler-Diehl V, Scifo E, Oganezova I, Hoffmann T, Gomez Martin P, Bertan F, Wrobel CJJ, Schroeder FC, Ehninger D, Händler K, Schultze JL, Schreiber L, van Echten-Deckert G, Nicotera P, Bano D. CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants. EMBO Reports 2022; doi:10.15252/embr.202152606.
8. Wischhof L, Adhikari A., Mondal M, Marsal-Cots A, Biernat J, Mandelkow EM, Mandelkow E, Ehninger D, Nicotera P, Bano D. Unbiased proteomic profiling reveals the IP3R modulator AHCYL1/IRBIT as a novel interactor of microtubule-associated protein tau. J Biol Chem 2022; doi: 10.1016/j.jbc.2022.101774.
9. Scheiblich H, Dansokho C, Mercan D, Schmidt SV, Bousset L, Wischhof L, Eikens F, Odainic A, Spitzer J, Griep A, Schwartz S, Bano D, Latz E, Melki R, and Heneka MT. Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes. Cell 2021; doi: 10.1016/j.cell.2021.09.007.
10. Bano D, Salomoni P, Ehninger D, and Nicotera P. The histone code in dementia: transcriptional and chromatin plasticity fades away. Current Opinion in Pharmacology 2021; doi: 10.1016/j.coph.2021.07.014.
11. Bertan F, Wischhof L, Scifo E, Guranda M, Jackson J, Marsal-cots A, Piazzesi A, Stork M, Peitz M, Prehn JHM, Ehninger D, Nicotera P and Bano D. Comparative analysis of CI and CIV-containing respiratory supercomplexes at single-cell resolution. Cell Reports Methods 2021; doi: 10.1016/j.crmeth.2021.100002.
12. Naia L, Pinho CM, Dentoni G, Liu J, Leal NS, Ferreira DMS, Schreiner B, Filadi R, Fão L, Connolly NMC, Forsell P, Nordvall G, Shimozawa M, Greotti E, Basso E, Theurey P, Gioran A, Joselin A, Arsenian-Henriksson M, Nilsson P, Rego AC, Ruas JL, Park D, Bano D, Pizzo P, Prehn JHM, and Ankarcrona M. Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling. BMC Biol 2021; doi: 10.1186/s12915-021-00979-5.
13. Hintze M, Griesing S, Michels M, Blanck B, Wischhof L, Hartmann D, Bano D, and Franz T. Alopecia in Harlequin mutant mice is associated with reduced AIF protein levels and expression of retroviral elements. Mamm Genome 2021; 32, 12-29. doi: 10.1007/s00335-020-09854-0
14. Xie K, Kapetanou M, Sidiropoulou K, Bano D, Gonos ES, Djordjevic AM, and Ehninger D. Signaling pathways of dietary energy restriction and metabolism on brain physiology and in age-related neurodegenerative diseases. Mech Ageing Dev 2020; 192, 111364. doi: 10.1016/j.mad.2020.111364.
15. Lountzi D, Henzel K, Jazbec K, Bano D, Krauss S, Rozman P, Ehninger D. Effects of heterochronic, non-myeloablative bone marrow transplantation on age-related behavioural changes in mice. Mech Ageing Dev. 2020;191:111327. doi: 10.1016/j.mad.2020.111327.
16. Bertan F, Wischhof L, Sosulina L, Mittag M, Dalugge D, Fornarelli A, Gardoni F, Marcello E, Di Luca M, Fuhrmann M, Remy S, Bano D, Nicotera P. Loss of Ryanodine Receptor 2 impairs neuronal activity-dependent remodeling of dendritic spines and triggers compensatory neuronal hyperexcitability. Cell Death Differ. 2020 Jul 8. doi: 10.1038/s41418-020-0584-2.
17. Kumar A, Bano D, Ehninger D. Cellular senescence in vivo: From cells to tissues to pathologies. Mech Ageing Dev. 2020 Sep; 190:111308. doi: 10.1016/j.mad.2020.111308.
18. Krabbendam IE, Honrath B, Dilberger B, Iannetti EF, Branicky RS, Meyer T, Evers B, Dekker FJ, Koopman WJH, Beyrath J, Bano D, Schmidt M, Bakker BM, Hekimi S, Culmsee C, Eckert GP, Dolga AM. SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans. Cell Death Dis. 2020 Apr 23;11(4):263. doi: 10.1038/s41419-020-2458-4.
19. Cavaliere F, Fornarelli A, Bertan F, Russo R, Marsal-Cots A, Morrone LA, Adornetto A, Corasaniti MT, Bano D, Bagetta G, Nicotera P. The tricyclic antidepressant clomipramine inhibits neuronal autophagic flux. Sci Rep. 2019 Mar 19;9(1):4881. doi: 10.1038/s41598-019-40887-x.
20. Gioran A, Piazzesi A, Bertan F, Schroer J, Wischhof L, Nicotera P, Bano D. Multi-omics identify xanthine as a pro-survival metabolite for nematodes with mitochondrial dysfunction. EMBO J. 2019 Feb 22. pii: e99558. doi: 10.15252/embj.201899558.
21. Theurey P, Connolly NMC, Fortunati I, Basso E, Lauwen S, Ferrante C, Moreira Pinho C, Joselin A, Gioran A, Bano D, Park DS, Ankarcrona M, Pizzo P, Prehn JHM. Systems biology identifies preserved integrity but impaired metabolism of mitochondria due to a glycolytic defect in Alzheimer's disease neurons. Aging Cell. 2019 Feb 21:e12924. doi: 10.1111/acel.12924.
22. Arnoux I, Willam M, Griesche N, Krummeich J, Watari H, Offermann N, Weber S, Narayan Dey P, Chen C, Monteiro O, Buettner S, Meyer K, Bano D, Radyushkin K, Langston R, Lambert JJ, Wanker E, Methner A, Krauss S, Schweiger S, Stroh A. Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease. Elife. 2018 Sep 4;7. pii: e38744. doi: 10.7554/eLife.38744.
23. Sellin J, Wingen C, Gosejacob D, Senyilmaz D, Hanschke L, Buttner S, Meyer K, Bano D, Nicotera P, Teleman AA, Bulow MH. Dietary rescue of lipotoxicity-induced mitochondrial damage in Peroxin19 mutants. PLoS Biol. 2018 Jun 19;16(6):e2004893. doi: 10.1371/journal.pbio.2004893.
24. Wischhof L, Gioran A, Sonntag-Bensch D, Piazzesi A, Stork M, Nicotera P, Bano D. A disease-associated Aifm1 variant induces severe myopathy in knockin mice. Mol Metab. 2018 Jul; 13:10-23. doi: 10.1016/j.molmet.2018.05.002.
25. Bano D, Prehn JHM. Apoptosis-Inducing Factor (AIF) in Physiology and Disease: The Tale of a Repented Natural Born Killer. EBioMedicine. 2018 Apr;30: 29-37. doi: 10.1016/j.ebiom.2018.03.016.
26. Troulinaki K, Buttner S, Marsal Cots A, Maida S, Meyer K, Bertan F, Gioran A, Piazzesi A, Fornarelli A, Nicotera P, Bano D. WAH-1/AIF regulates mitochondrial oxidative phosphorylation in the nematode Caenorhabditis elegans. Cell Death Discov. 2018 Jan 29;4:2. doi: 10.1038/s41420-017-0005-6.
27. Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolanos JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Dussmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, Jekabsons MB, Jonas EA, Jordan J, Lipton SA, Manfredi G, Mattson MP, McLaughlin B, Methner A, Murphy AN, Murphy MP, Nicholls DG, Polster BM, Pozzan T, Rizzuto R, Satrustegui J, Slack RS, Swanson RA, Swerdlow RH, Will Y, Ying Z, Joselin A, Gioran A, Moreira Pinho C, Watters O, Salvucci M, Llorente-Folch I,. Park DS, Bano D, Ankarcrona M, Pizzo P, Prehn JHM. Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases. Cell Death Differ. 2018 Mar;25(3):542-572. doi: 10.1038/s41418-017-0020-4.
28. Wischhof L, Maida S, Piazzesi A, Gioran A, Barragan Sanz K, Irsen S, Beyer M, Schultze JL, Dyer MJ, Salomoni P, Ehninger D, Nicotera P, Bano D. The SWI/SNF subunit Bcl7a contributes to motor coordination and Purkinje cell function. Sci Rep. 2017 Dec 6;7(1):17055. doi: 10.1038/s41598-017-17284-3.
29. Bano D, Ankarcrona M. Beyond the critical point: An overview of excitotoxicity, calcium overload and the downstream consequences. Neurosci Lett. 2018 Jan 10;663:79-85. doi: 10.1016/j.neulet.2017.08.048.
30. Bano D, Piazzesi A, Salomoni P, Nicotera P. The histone variant H3.3 claims its place in the crowded scene of epigenetics. Aging (Albany NY). 2017 Mar 10;9(3):602-614. doi: 10.18632/aging.101194.
31. Bano D, Jewell SA, Nicotera P. Calcium signaling then and now, via Stockholm. Biochem Biophys Res Commun. 2017 Jan 15;482(3):384-387. doi: 10.1016/j.bbrc.2016.11.151.
32. Piazzesi A, Papic D, Bertan F, Salomoni P, Nicotera P, Bano D. Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs. Cell Rep. 2016 Oct 18;17(4):987-996. doi: 10.1016/j.celrep.2016.09.074.
33. Meyer K, Buettner S, Ghezzi D, Zeviani M, Bano D, Nicotera P. Loss of apoptosis-inducing factor critically affects MIA40 function. Cell Death Dis. 2015 Jul 9;6:e1814. doi: 10.1038/cddis.2015.170.
34. Schmole AC, Lundt R, Ternes S, Albayram O, Ulas T, Schultze JL, Bano D, Nicotera P, Alferink J, Zimmer A. Cannabinoid receptor 2 deficiency results in reduced neuroinflammation in an Alzheimer's disease mouse model. Neurobiol Aging. 2015 Feb;36(2):710-9. doi: 10.1016/j.neurobiolaging.2014.09.019.
35. Jakubik M, Floriddia EM, Nicotera P, Bano D. Heterozygous Igf1r deletion does not ameliorate pathological features associated with polyglutamine-containing huntingtin fragment. Neurosci Lett. 2014 Sep 19; 580: 52-5. doi: 10.1016/j.neulet.2014.07.049.
36. Sendoel A, Maida S, Zheng X, Teo Y, Stergiou L, Rossi CA, Subasic D, Pinto SM, Kinchen JM, Shi M, Boettcher S, Meyer JN, Manz MG, Bano D, Hengartner MO. DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis. Nat Cell Biol. 2014 Aug;16(8):812-20. doi: 10.1038/ncb3010.
37. Gioran A, Nicotera P, Bano D. Impaired mitochondrial respiration promotes dendritic branching via the AMPK signaling pathway. Cell Death Dis. 2014 Apr 10; 5: e1175. doi: 10.1038/cddis.2014.144.
38. Hofmann JP, Denner P, Nussbaum-Krammer C, Kuhn PH, Suhre MH, Scheibel T, Lichtenthaler SF, Schatzl HM, Bano D, Vorberg IM. Cell-to-cell propagation of infectious cytosolic protein aggregates. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):5951-6. doi: 10.1073/pnas.1217321110.
39. Troulinaki K, Bano D. Mitochondrial deficiency: a double-edged sword for aging and neurodegeneration. Front Genet. 2012 Nov 26; 3: 244. doi: 10.3389/fgene.2012.00244.
40. Bano D, Zanetti F, Mende Y, Nicotera P. Neurodegenerative processes in Huntington's disease. Cell Death Dis. 2011 Nov 10; 2: e228. doi: 10.1038/cddis.2011.112.
41. Killick R, Niklison-Chirou M, Tomasini R, Bano D, Rufini A, Grespi F, Velletri T, Tucci P, Sayan BS, Conforti F, Gallagher E, Nicotera P, Mak TW, Melino G, Knight RA, Agostini M. p73: a multifunctional protein in neurobiology. Mol Neurobiol. 2011 Apr;43(2):139-46. doi: 10.1007/s12035-011-8172-6.
42. Bano D, Hengartner MO, Nicotera P. Nuclear pore complex during neuronal degeneration: cracking the last barrier! Nucleus. 2010 Mar-Apr;1(2):136-8. doi: 10.4161/nucl.1.2.10798.
43. Bano D, Agostini M, Melino G, Nicotera P. Ageing, neuronal connectivity and brain disorders: an unsolved ripple effect. Mol Neurobiol. 2011 Apr;43(2):124-30. doi: 10.1007/s12035-011-8164-6.
44. Ziviani E, Lippi G, Bano D, Munarriz E, Guiducci S, Zoli M, Young KW, Nicotera P. Ryanodine receptor-2 upregulation and nicotine-mediated plasticity. EMBO J. 2011 Jan 5;30(1):194-204. doi: 10.1038/emboj.2010.279.
45. Agostini M, Tucci P, Chen H, Knight RA, Bano D, Nicotera P, McKeon F, Melino G. p73 regulates maintenance of neural stem cell. Biochem Biophys Res Commun. 2010 Dec 3;403(1):13-7. doi: 10.1016/j.bbrc.2010.10.087.
46. Bano D, Dinsdale D, Cabrera-Socorro A, Maida S, Lambacher N, McColl B, Ferrando-May E, Hengartner MO, Nicotera P. Alteration of the nuclear pore complex in Ca(2+)-mediated cell death. Cell Death Differ. 2010 Jan;17(1):119-33. doi: 10.1038/cdd.2009.112.
47. Young KW, Bampton ET, Pinon L, Bano D, Nicotera P. Mitochondrial Ca2+ signalling in hippocampal neurons. Cell Calcium. 2008 Mar;43(3):296-306. doi: 10.1016/J.CECA.2007.06.007.
48. Bano D, Munarriz E, Chen HL, Ziviani E, Lippi G, Young KW, Nicotera P. The plasma membrane Na+/Ca2+ exchanger is cleaved by distinct protease families in neuronal cell death. Ann N Y Acad Sci. 2007 Mar; 1099: 451-5. doi: 10.1196/ANNALS.1387.006.
49. Bano D, Nicotera P. Ca2+ signals and neuronal death in brain ischemia. Stroke. 2007 Feb;38(2 Suppl):674-6. doi: 10.1161/01.STR.0000256294.46009.29.
50. Berliocchi L, Bano D, Nicotera P. Ca2+ signals and death programmes in neurons. Philos Trans R Soc Lond B Biol Sci. 2005 Dec 29;360(1464):2255-8. doi: 10.1098/RSTB.2005.1765.
51. Munarriz E, Bano D, Sayan AE, Rossi M, Melino G, Nicotera P. Calpain cleavage regulates the protein stability of p73. Biochem Biophys Res Commun. 2005 Aug 5;333(3):954-60. doi: 10.1016/J.BBRC.2005.05.188.
52. Bano D, Young KW, Guerin CJ, Lefeuvre R, Rothwell NJ, Naldini L, Rizzuto R, Carafoli E, Nicotera P. Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity. Cell. 2005 Jan 28;120(2):275-85. doi: 10.1016/J.CELL.2004.11.049.
53. Nicotera P, Bano D. The enemy at the gates. Ca2+ entry through TRPM7 channels and anoxic neuronal death. Cell. 2003 Dec 26;115(7):768-70. doi: 10.1016/S0092-8674(03)01019-5.
54. Schwab BL, Guerini D, Didszun C, Bano D, Ferrando-May E, Fava E, Tam J, Xu D, Xanthoudakis S, Nicholson DW, Carafoli E, Nicotera P. Cleavage of plasma membrane calcium pumps by caspases: a link between apoptosis and necrosis. Cell Death Differ. 2002 Aug;9(8):818-31. doi: 10.1038/SJ.CDD.4401042.
55. Brini M, Bano D, Manni S, Rizzuto R, Carafoli E. Effects of PMCA and SERCA pump overexpression on the kinetics of cell Ca(2+) signalling. EMBO J. 2000 Sep 15;19(18):4926-35. doi: 10.1093/EMBOJ/19.18.4926.
56. Branca D, Gugliucci A, Bano D, Brini M, Carafoli E. Expression, partial purification and functional properties of themuscle-specific calpain isoform p94. Eur J Biochem. 1999 Oct;265(2):839-46. doi: 10.1046/j.1432-1327.1999.00817.x.