ALESSIA ANGELIN

Researcher

email: alessia.angelin@uniroma2.it
phone: +39 06 7259 6927
building: F Nord, I floor
room: F178

Dr. Alessia Angelin obtained her Master’s Degree in Biological Sciences from the University of Padua, Italy, with a thesis on the biochemical characterization of mitochondrial function under the supervision of Prof. Paolo Bernardi. At the University of Padua, she also obtained her PhD in Molecular and Cellular Biology and Pathology, working on the role of mitochondria in human muscular dystrophies, again under the supervision of Prof. Bernardi.  

Dr. Angelin has 15 years of international research experience in biochemistry and biomedical sciences, and her research primarily focuses on the physiology of mitochondria in human diseases. During these years, she worked as a postdoctoral scholar at the University of Padova, the University of California-Irvine (USA), and the Children’s Hospital of Philadelphia (USA) under the supervision of Prof. Douglas C. Wallace.  Dr. Angelin consolidated her position as a Senior Research Scientist at the Center for Mitochondrial and Epigenomic Medicine, directed by Prof. Wallace, at the Children’s Hospital of Philadelphia. She investigated the mitochondrial contribution to the pathophysiology of human cardiomyopathy and muscular dystrophy and recently developed an AAV-based gene therapy for treating human mitochondrial cardiac disorder. Over the years, her scientific interests have expanded to include the role of mitochondria in immune deficiencies and infection, metabolic diseases, and cancer. 

In 2024, she returned to Italy as an Assistant Professor in Biochemistry at the University of Rome Tor Vergata, School of Medicine.  In Prof. Eleonora Candi’s laboratory, she studies the metabolic changes that occur in the transformation of neoplastic cells and tumor proliferation using cellular and murine models with biochemical techniques and omics characterization, with particular attention to the role of mitochondria. 

Currently, Dr. Angelin is mainly involved in two projects: (i) characterizing the role of p63 in regulating muscular differentiation and (ii) investigating the contribution of the polyol pathway in tumor development. Dr. Angelin has published 32 peer-reviewed articles and attended about 40 scientific conferences, several as an invited speaker.  Dr. Angelin teaches Biochemistry in the Pharmacy Degree Course


Research products

2108/366445 - 2024 - SARS-CoV-2 mitochondrial metabolic and epigenomic reprogramming in COVID-19
Angelin, Alessia - 01 - Articolo su rivista
paper: PHARMACOLOGICAL RESEARCH (Attuale:ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 24-28 OVAL RD, LONDON, ENGLAND, NW1 7DX Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 1-12 - issn: 1043-6618 - wos: WOS:001237033600001 (12) - scopus: 2-s2.0-85191416648 (13)

2108/392251 - 2024 - Mitochondrial antioxidants abate SARS-COV-2 pathology in mice
Angelin, Alessia - 01 - Articolo su rivista
paper: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (Editore National Academy of Sciences a Washington, DC) pp. - - issn: 1091-6490 - wos: WOS:001408635500004 (7) - scopus: 2-s2.0-85199015464 (7)

2108/366403 - 2024 - Correction to: Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP) (Nature Cell Biology, (2023), 25, 8, (1089-1100), 10.1038/s41556-023-01194-w)
Angelin, Alessia - 01 - Articolo su rivista
paper: NATURE CELL BIOLOGY (Nature America Incorporated:345 Park Avenue South, 6th Floor:New York, NY 10010:(888)331-6288, EMAIL: institutions@natureny.com, INTERNET: http://www.nature.com, Fax: (212)689-9108) pp. 839- - issn: 1465-7392 - wos: WOS:001178926100006 (0) - scopus: 2-s2.0-85193317330 (1)

2108/392252 - 2024 - Lethal COVID-19 associates with RAAS-induced inflammation for multiple organ damage including mediastinal lymph nodes
Angelin, Alessia - 01 - Articolo su rivista
paper: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (National Academy of Sciences:2101 Constitution Avenue Northwest:Washington, DC 20418:(877)314-2253, (615)377-3322, EMAIL: subspnas@nas.edu, INTERNET: http://www.pnas.org, Fax: (615)377-0525) pp. - - issn: 0027-8424 - wos: WOS:001377038800002 (2) - scopus: 2-s2.0-85211073743 (2)

2108/366424 - 2023 - Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts
Angelin, Alessia - 01 - Articolo su rivista
paper: SCIENCE TRANSLATIONAL MEDICINE (Washington, DC : American Association for the Advancement of Science) pp. - - issn: 1946-6242 - wos: WOS:001045323500002 (81) - scopus: 2-s2.0-85167531710 (86)

2108/366404 - 2023 - Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)
Angelin, Alessia - 01 - Articolo su rivista
paper: NATURE CELL BIOLOGY (Nature America Incorporated:345 Park Avenue South, 6th Floor:New York, NY 10010:(888)331-6288, EMAIL: institutions@natureny.com, INTERNET: http://www.nature.com, Fax: (212)689-9108) pp. 1089-1100 - issn: 1465-7392 - wos: WOS:001036982000001 (67) - scopus: 2-s2.0-85165153199 (62)

2108/366304 - 2023 - SARS-COV-2 viroporins activate the NLRP3-inflammasome by the mitochondrial permeability transition pore
Angelin, Alessia - 01 - Articolo su rivista
paper: FRONTIERS IN IMMUNOLOGY (Lausanne : Frontiers Research Foundation, 2010-) pp. - - issn: 1664-3224 - wos: WOS:000943695200001 (26) - scopus: 2-s2.0-85149621235 (29)

2108/366423 - 2023 - Cyclin-dependent kinases regulate the adult nervous system via the one-carbon-metabolism
Angelin, Alessia - 01 - Articolo su rivista
paper: CELL DEATH & DISEASE (Nature Group) pp. 1-3 - issn: 2041-4889 - wos: WOS:001030558800005 (0) - scopus: 2-s2.0-85164759568 (0)

2108/366425 - 2020 - Lactate Limits T Cell Proliferation via the NAD(H) Redox State
Angelin, Alessia - 01 - Articolo su rivista
paper: CELL REPORTS (Elsevier B.V. Cambridge MA: Cell Press) pp. 1-16 - issn: 2211-1247 - wos: WOS:000599512500011 (209) - scopus: 2-s2.0-85097770291 (210)

2108/366263 - 2020 - Collagen VI Deficiency Results in Structural Abnormalities in the Mouse Lung
Angelin, Alessia - 01 - Articolo su rivista
paper: THE AMERICAN JOURNAL OF PATHOLOGY (American Society for Investigative Pathology:9650 Rockville Pike:Bethesda, MD 20814:(301)634-7130, EMAIL: asjp@asip.org, INTERNET: http://www.asip.org, Fax: (301)634-7990) pp. 426-441 - issn: 0002-9440 - wos: WOS:000509437800013 (13) - scopus: 2-s2.0-85077927411 (14)

2108/366443 - 2020 - HDAC10 deletion promotes Foxp3+ T-regulatory cell function
Angelin, Alessia - 01 - Articolo su rivista
paper: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. 1-13 - issn: 2045-2322 - wos: WOS:000551460600004 (48) - scopus: 2-s2.0-85077942167 (50)

2108/366484 - 2019 - Mitochondrial DNA Variation Dictates Expressivity and Progression of Nuclear DNA Mutations Causing Cardiomyopathy
Angelin, Alessia - 01 - Articolo su rivista
paper: CELL METABOLISM (CELL PRESS, Cambridge (MA) USA) pp. 78-90 - issn: 1550-4131 - wos: WOS:000455090100012 (51) - scopus: 2-s2.0-85059795017 (51)

2108/366526 - 2019 - Premature Lambs Exhibit Normal Mitochondrial Respiration after Long-Term Extrauterine Support
Angelin, Alessia - 01 - Articolo su rivista
paper: FETAL DIAGNOSIS AND THERAPY (S Karger AG:Allschwilerstrasse 10, CH-4009 Basel Switzerland:011 41 61 3061111, EMAIL: orders@karger.ch, INTERNET: http://www.karger.com, Fax: 011 41 61 3061234) pp. 306-312 - issn: 1015-3837 - wos: WOS:000497713700003 (13) - scopus: 2-s2.0-85063388313 (9)

2108/366343 - 2019 - H+ transport is an integral function of the mitochondrial ADP/ATP carrier
Angelin, Alessia - 01 - Articolo su rivista
paper: NATURE (London: Nature Pubihing. Group-Springer Nature Limited -London : Macmillan, 1869- -New York, NY; Nature America Incorporated) pp. 515-520 - issn: 0028-0836 - wos: WOS:000477016700061 (195) - scopus: 2-s2.0-85069716355 (207)

2108/366464 - 2017 - Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments
Angelin, Alessia - 01 - Articolo su rivista
paper: CELL METABOLISM (CELL PRESS, Cambridge (MA) USA) pp. 1282-1293 - issn: 1550-4131 - wos: WOS:000402961500009 (859) - scopus: 2-s2.0-85017467396 (909)

2108/366525 - 2016 - Deficiency in the mouse mitochondrial adenine nucleotide translocator isoform 2 gene is associated with cardiac noncompaction
Angelin, Alessia - 01 - Articolo su rivista
paper: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 1203-1212 - issn: 0005-2728 - wos: WOS:000378179300019 (24) - scopus: 2-s2.0-84964335000 (25)

2108/366364 - 2016 - Mitochondrial respiration is sensitive to cytoarchitectural breakdown
Angelin, Alessia - 01 - Articolo su rivista
paper: INTEGRATIVE BIOLOGY (Cambridge : Royal Society of Chemistry, 2009-) pp. 1170-1182 - issn: 1757-9694 - wos: WOS:000387979900007 (18) - scopus: 2-s2.0-84995632236 (18)

2108/366283 - 2015 - Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion
Angelin, Alessia - 01 - Articolo su rivista
paper: SCIENCE SIGNALING () pp. - - issn: 1937-9145 - wos: WOS:000360807900002 (83) - scopus: 2-s2.0-84939142927 (85)

2108/366485 - 2015 - Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival
Angelin, Alessia - 01 - Articolo su rivista
paper: THE FASEB JOURNAL (Federation of American Societies for Experimental Biology (FASEB):9650 Rockville Pike, Room L-2310:Bethesda, MD 20814:(800)433-2732, (301)530-7027, EMAIL: staff@dues.faseb.org, INTERNET: http://www.faseb.org, Fax: (301)571-5728, (301)530-7001) pp. 2315-2326 - issn: 0892-6638 - wos: WOS:000355209500010 (224) - scopus: 2-s2.0-84933532719 (235)

2108/366426 - 2015 - Erratum: Landscape of the mitochondrial Hsp90 metabolome in tumours (Nature Communications (2013) 4 (2139) DOI:10.1038/ncomms3139)
Angelin, Alessia - 01 - Articolo su rivista
paper: NATURE COMMUNICATIONS (London: Nature Publishing Group-Springer Nature) pp. - - issn: 2041-1723 - wos: (0) - scopus: 2-s2.0-84934994302 (1)

2108/366527 - 2014 - Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and Aβ42-induced neurodegeneration
Angelin, Alessia - 01 - Articolo su rivista
paper: AGING CELL (-MALDEN:WILEY-BLACKWELL PUBLISHING, INC. -Oxford : Blackwell, 2002-) pp. 507-518 - issn: 1474-9718 - wos: WOS:000337523400013 (63) - scopus: 2-s2.0-84901463419 (62)

2108/366384 - 2013 - Landscape of the mitochondrial Hsp90 metabolome in tumours
Angelin, Alessia - 01 - Articolo su rivista
paper: NATURE COMMUNICATIONS (London: Nature Publishing Group-Springer Nature) pp. - - issn: 2041-1723 - wos: WOS:000323716300009 (136) - scopus: 2-s2.0-84880299429 (138)

2108/366463 - 2012 - Critical evaluation of the use of cell cultures for inclusion in clinical trials of patients affected by collagen VI myopathies
Angelin, Alessia - 01 - Articolo su rivista
paper: JOURNAL OF CELLULAR PHYSIOLOGY (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 2927-2935 - issn: 0021-9541 - wos: WOS:000301709700016 (14) - scopus: 2-s2.0-84858625921 (14)

2108/366523 - 2012 - Mitochondrial DNA variant associated with Leber hereditary optic neuropathy and high-altitude Tibetans
Angelin, Alessia - 01 - Articolo su rivista
paper: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (National Academy of Sciences:2101 Constitution Avenue Northwest:Washington, DC 20418:(877)314-2253, (615)377-3322, EMAIL: subspnas@nas.edu, INTERNET: http://www.pnas.org, Fax: (615)377-0525) pp. 7391-7396 - issn: 0027-8424 - wos: WOS:000304090600057 (113) - scopus: 2-s2.0-84860806864 (119)

2108/366503 - 2011 - Cyclosporine a in Ullrich congenital muscular dystrophy: Long-term results
Angelin, Alessia - 01 - Articolo su rivista
paper: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (London: Hindawi AUSTIN, USA, TX: LANDES BIOSCIENCE) pp. 1-11 - issn: 1942-0900 - wos: WOS:000298611200001 (44) - scopus: 2-s2.0-84855323182 (51)

2108/366524 - 2010 - Autophagy is defective in collagen VI muscular dystrophies, and its reactivation rescues myofiber degeneration
Angelin, Alessia - 01 - Articolo su rivista
paper: NATURE MEDICINE (Nature America Incorporated:345 Park Avenue South, 6th Floor:New York, NY 10010:(888)331-6288, EMAIL: institutions@natureny.com, INTERNET: http://www.nature.com, Fax: (212)689-9108) pp. 1313-1320 - issn: 1078-8956 - wos: WOS:000283860100044 (425) - scopus: 2-s2.0-78149319082 (455)

2108/366505 - 2009 - Lentiviral-mediated RNAi in vivo silencing of Col6a1, a gene with complex tissue specific expression pattern
Angelin, Alessia - 01 - Articolo su rivista
paper: JOURNAL OF BIOTECHNOLOGY (Amsterdam Netherlands: Elsevier BV) pp. 8-17 - issn: 0168-1656 - wos: WOS:000266174600002 (11) - scopus: 2-s2.0-64249083170 (12)

2108/366528 - 2009 - Respiratory complex I dysfunction due to mitochondrial DNA mutations shifts the voltage threshold for opening of the permeability transition pore toward resting levels
Angelin, Alessia - 01 - Articolo su rivista
paper: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 2045-2052 - issn: 0021-9258 - wos: WOS:000426354000802 (0) - scopus: 2-s2.0-59049097778 (91)

2108/366444 - 2009 - The cyclophilin inhibitor Debio 025 normalizes mitochondrial function, muscle apoptosis and ultrastructural defects in Col6a1-/-myopathic mice
Angelin, Alessia - 01 - Articolo su rivista
paper: BRITISH JOURNAL OF PHARMACOLOGY (Basingstoke: Nature Publishing Group London: Macmillan, 1968-) pp. 1045-1052 - issn: 0007-1188 - wos: WOS:000268260800019 (99) - scopus: 2-s2.0-65549104874 (113)

2108/366386 - 2009 - Genetic ablation of cyclophilin D rescues mitochondrial defects and prevents muscle apoptosis in collagen VI myopathic mice
Angelin, Alessia - 01 - Articolo su rivista
paper: HUMAN MOLECULAR GENETICS (Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485) pp. 2024-2031 - issn: 0964-6906 - wos: WOS:000265951600011 (102) - scopus: 2-s2.0-65549087972 (108)

2108/366383 - 2008 - Cyclosporin A corrects mitochondrial dysfunction and muscle apoptosis in patients with collagen VI myopathies
Angelin, Alessia - 01 - Articolo su rivista
paper: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (National Academy of Sciences:2101 Constitution Avenue Northwest:Washington, DC 20418:(877)314-2253, (615)377-3322, EMAIL: subspnas@nas.edu, INTERNET: http://www.pnas.org, Fax: (615)377-0525) pp. 5225-5229 - issn: 0027-8424 - wos: WOS:000254723700049 (170) - scopus: 2-s2.0-42449109035 (185)

2108/366303 - 2008 - Altered threshold of the mitochondrial permeability transition pore in Ullrich congenital muscular dystrophy
Angelin, Alessia - 01 - Articolo su rivista
paper: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 893-896 - issn: 0005-2728 - wos: WOS:000257696400047 (31) - scopus: 2-s2.0-46349109604 (34)

2108/366323 - 2007 - Mitochondrial dysfunction in the pathogenesis of Ullrich congenital muscular dystrophy and prospective therapy with cyclosporins
Angelin, Alessia - 01 - Articolo su rivista
paper: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (National Academy of Sciences:2101 Constitution Avenue Northwest:Washington, DC 20418:(877)314-2253, (615)377-3322, EMAIL: subspnas@nas.edu, INTERNET: http://www.pnas.org, Fax: (615)377-0525) pp. 991-996 - issn: 0027-8424 - wos: WOS:000243761100056 (153) - scopus: 2-s2.0-33846477445 (174)

2108/366446 - 2004 - Yessotoxin, a shellfish biotoxin, is a potent inducer of the permeability transition in isolated mitochondria and intact cells
Angelin, Alessia - 01 - Articolo su rivista
paper: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 139-147 - issn: 0005-2728 - wos: WOS:000222220500007 (47) - scopus: 2-s2.0-2642544732 (52)

2108/366504 - 2004 - Arachidonic acid released by phospholipase A2 activation triggers Ca2+-dependent apoptosis through the mitochondrial pathway
Angelin, Alessia - 01 - Articolo su rivista
paper: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 25219-25225 - issn: 0021-9258 - wos: WOS:000221827900039 (142) - scopus: 2-s2.0-2942530420 (150)

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