EDUCATION:
Management courses:
2011, leadership program; 2008, Female Development
Program (Erasmus MC)
Didactic courses followed:
• 2018: Coaching workshop
• 2017: BKO certificate
• 2016: Workshop Flipping the classroom. Erasmus Desiderius School
• 2000: Keuze-onderwijs: Opzet, begeleiding en beoordeling (Smidts en Wijnen,
onderwijs en advies)
• 1998: Basisdidactiek OECR (Onderwijskundig Expertise Centrum Rotterdam)
General Education
1995: PhD at Erasmus University Rotterdam, The Netherlands
Thesis: Anti-müllerian hormone and androgens: Regulation of receptors during sex
differentiation and gonadal development
Promotor: prof.dr. J. Anton Grootegoed
Co-promotor: Dr. APN Themmen
1989: MSc Molecular Sciences (cum laude) at Wageningen University, The Netherlands
1983: Atheneum, Scholengemeenschap Dukenburg, Nijmegen
Employment
Jan 2010-present: Associate professor, Department of Developmental Biology,
Erasmus MC Rotterdam, The Netherlands (IUS promovendi since 2021)
Jan 2000—jan 2010: Assistant professor, Department of Reproduction and
Development, Erasmus MC Rotterdam, The Netherlands
July 1995-Jan 2000: Post-doc, Department of Reproduction and Development, Erasmus
University Rotterdam, The Netherlands
May 1989-July 1994: PhD student Erasmus University Rotterdam, The Netherlands
Short Overview of Research and Teaching Activities
RESEARCH: Dr. WM Baarends focused on sex differentiation (cloned and characterized the anti-mullerian hormone type II receptor) during her PhD and has since then maintained an interest in gonadal differentiation throughout her career, expressed through teaching (see below), and via studies on the enigmatic sex determination process of the mole vole Ellobius Lutescens, that has lost its Y chromosome approximately 2 million years ago. Since 1996, her main research lines focus on meiosis, and in particular on the homologous chromosome pairing process that precedes this very special reductional division that is crucial to sexual reproduction. She studies the special regulation of the X and Y chromosome pairing process in males, and asks how homologous chromosomes recognize each other and avoid the “wrong” partner. To answer these questions, she uses mouse models of infertility, and state of the art microscopic analyses. In addition, she is currently setting up in vitro meiosis to more easily model and manipulate meiotic chromosome pairing. In addition, she works on developing an in vitro differentiation protocol from mouse ES cells and human iPSC cells to obtain embryonic gonadal cells, that should differentiate along male and female sex determination pathways depending on their genetic constitution (XY, or XX, respectively). In collaboration with the Gynaecology and Obstetrics and Urology Departments of the Erasmus MC she applies this basic science knowledge to obtain novel insight in the causes of meiotic arrest in infertile men, and the possible risks associated with assisted reproductive technology.
TEACHING: Dr. WM Baarends lectures in an evolutionary developmental biology course for 2nd year Nanobiology Bachelor students (Erasmus MC-TU Delft) and in several courses for Master students Molecular medicine (Erasmus MC). She also gives lectures and practicals on sex determination and differentiation, and on gametogenesis and meiosis to bachelor Medicine students. She has set up, and also
coordinated courses on scientific proposal writing for Master students Molecular Medicine and Nanobiology, and a presentation skills course for Molecular Medicine students. She is coordinator of the program of year 1 of the research master Molecular medicine. She also is coordinator of the Erasmus MC Querido Honours College (QHC, http://queridohonourscollegeerasmusmc.nl) since 2017, and has made important contributions to the setup of several new components of the curriculum of this Honours program for Medicine students that aims to broaden and deepen the knowledge of the students, and make them aware of their responsibility to contribute to a healthy society. One important new development bridges the gap between this Honours program and the research Master programs by including an extra year (3th bachelor year) that involves a research project organized and conducted by each individual student, to stimulate their research skills and awareness of the importance of combining research and clinical activities. In this context, dr. Baarends has also setup a short laboratory course for the QHC students to provide them with wet-lab skills, and help them decide the type of research they would like to conduct. She also developed and teaches a brief module to develop their biomedical literature reading skills. Dr Baarends also contributed (together with Prof. dr Charles Boucher and dr. Ed van Beeck) to setting up a new bureau, run by QHC students, that bridges the gap between Medicine students and society by coordinating social projects and research in the Rotterdam area (“Geneeskundestudenten in de samenleving” (GIDS)). Her vision on future teaching at Erasmus MC is to initiate development of teaching tools that will help to prepare future generations of physician-researchers to tackle current complex health related societal problems that require an interdisciplinary approach, to help reduce the barriers between the different faculties of the EUR/Erasmus MC and TU Delft, and to urther optimize the excellence program to support personal development of our future leaders, while maintaining resilience.
Supervision of PhD theses (Co-promoter)
Roald van der Laan (June 2004): mRAd18Sc: a multifunctinal protein in replicative damage bypass and gametogenesis. Promotor prof. dr. JHJ Hoeijmakers
Evert-Jan Uringa (September 2005): Functions and dynamics of DNA repair proteins in mitosis and meiosis. Promotor prof. dr. JA Grootegoed
Sam Schoenmakers (October 2010): Silencing of Sex chromosomes: from meiosis to early embryonic development. Promotors: prof. dr. JA Grootegoed and prof dr. JSE
Laven
Akiko Inagaki (October 2010): Meiotic and mitotic functions of mammalian RAD18 in DNA double-strand break repair. Promotor: prof. dr. JA Grootegoed
Eskeatnaf Mulugeta Achame (June 2012): Dynamics of mammalian X and Y chromosomes in evolution and development. Promotors: prof. dr. JA Grootegoed and prof. dr. J Gribnau.
Fabrizia Carofiglio (Oct 2014): Zooming on chromosomes in mouse meiosis. Promotor: prof. dr. J.A. Grootegoed.
Peng Shang (Dec 2014): Testis-specific protein kinases TSSK1 and TSSK2 in mouse spermatogenesis. Promotor: prof. dr. J.A. Grootegoed.
Federica Federici (March 2015): Life cycle of the X chromosome. Promotors: prof. dr. JA Grootegoed and prof dr. JSE Laven
Aristea Magaraki: (Jan 2017)Epigenetic regulation of primordial germ cells. Promotor: Prof. Dr J. Gribnau
Andrea Enguita Marruedo: (June 2019) Dynamics of mouse and human gametogenesis: From microscopic analyses using
Supervision of PhD theses (Promoter)
Lieke Koornneef: (November 2023) Loading and positioning of recombinases during meiotic prophase in mice.
Currently supervising:
Kaylee Holleman (in collaboration with dr E Baart Clinical Embryologist, Department of Obstetrics and Gynaecology, Erasmus MC) Human sperm (epi)genetic quality. Started
Oct 2018
Aditya N. Mhaskar: In vitro modelling of mouse meiotic DNA double-strand break formation and repair. Started March 2020
Arina Puchkina: Development of models to generate the somatic gonadal niche to support in vitro meiosis and to study sex determination. Started September 2021
Ilse de Bruin: Development of human oocytes from iPSC cells. Started January 2022
Nina Dartee: Development of human granulosa cells from iPSC cells. Started February 2023
Reading committee:
• Zhiqian Liu (August 2006, McGill University Canada). E3Histone/LASU1, a 500 kDa novel multi-functional ubiquitin protein ligase.
• Femke de Boer (Januari 2007, Leiden University, The Netherlands). The role of homologous recombination in mitotic and meiotic double-strand break repair. Promotor prof. dr. ir. AA van Zeeland
• Godfried W van der Heijden and Alwin AHA Derijck (November 2007, Radboud MC,
Nijmegen, The Netherlands). The transmission of chromatin and DNA lesions by sperm and their fate in the zygote. Promotor prof. dr. JAM Kremer.
• Noorjahan Jagular Basheer (May 2011, Erasmus MC, Rotterdam, The Netherlands) Role of Oct6 in peripheral nerve Myelination. Promoter prof. dr. DN Meijer.
• Eerik Aunin (January 2012, Erasmus MC, Rotterdam, The Netherlands) Role of Lgi2 and Lgi3 in mouse nervous system development. Promoter prof. dr. DN Meijer.
• Ilse M van den Berg (February 2012, Erasmus MC, Rotterdam, The Netherlands) Epigenetic reprogramming during human oocyte maturation and early human development. Promotor Prof. Dr JSE Laven and Prof. Dr. FG Grosveld
• Marieke de Vries (October 2012, Radboud MC, Nijmegen, The Netherlands) A cytological exploration of human spermatogenesis in non-obstructive azoospermia patients: an analysis of variation. Promoter prof. dr. JAM Kremer
• Linde Kegel (April 2013, Erasmus MC , Rotterdam, The Netherlands) Role and specificity of LGI4-ADAM22 interactions in peripheral nerve myelination. Promoter
prof. dr. DN Meijer.
• Jessica Zuin (June 2013, Erasmus MC, Rotterdam, The Netherlands) Keep in touch! The role of cohesion and CTCF in organizing the human Genome. Promotor prof. dr.
FG Grosveld
• Widia Soochit (November2013, Erasmus MC, Rotterdam, The Netherlands) Fingers in action! Chromatin organization and transcriptional regulation by CTCF and
CTCFL. Promotor prof dr. FG Grosveld.
• Roberta Sarno (September 2014, Université Piere et Marie Curie, Paris, France)
targeting of meiotic recombination in the yeast Saccharomyces cerevisiae. Promotor Prof. Dr. A Nicolas
• Inger Brandsma (April 2016, Erasmus MC, Rotterdam, The Netherlands) Balancing pathways in DNA double-strand break repair. Promotor Prof. Dr. JHJ Hoeijmakers.
• Antoni Riera (Jan 2017, University of Florence, Italy) Genetic investigation in nonobstructive azoospermia: from the X chromosome to the whole exome. Promotor Prof. dr. C Krausz
• Maarten Paul (April 2017, Erasmus MC, Rotterdam, The Netherlands). Promotor Prof. Dr. AB Houtsmuller
• Yi Zheng (February 2018, University of Amsterdam, the Netherlands) Genome
integrity maintenance during spermatogonial development. Promotor Prof. dr. S Repping
• Imrul Faisal (May 2018, University of Helsinki, Finnland).! Genetic Regulation of Mammalian Spermatogenesis - studies of USF1 and MAD2. Supervisor dr. Liisa
Kauppi, Custos prof. dr. H. Sariola
• Igor Mačinković (November 2020, Philipps-Universität Marburg, Germany) Distinct CoREST complexes act in a cell-type-specific manner. Supervisor Prf. Dr. Alexander Brehm.
• Irene Escudero Selma (September 2023, Erasmus MC, Rotterdam, The Netherlands). Promotor, Prof. Dr, FFE Huylebroeck.
• Teresa Robert Finestra (October 2023, Erasmus MC, Rotterdam, The Netherlands). Promotors, Prof. Dr. JH Gribnau and Prof. Dr. JWM Martens.
• Ursula Stalmann (October 2023, Erasmus MC Rotterdam, The Netherlands, Promotor Prof. Dr. JH Gribnau)
• Cynthia Lungu (May 2024, Erasmus MC Rotterdam, The Netherlands, Promotor Prof. Dr. T Mahmoudi)
Large committee:
• Member of seventeen large PhD theses committees at Erasmus MC/EUR (Kim Monkorst 2008; Linda Brugmans 2009; Alex Faesen 2011; LM Uittenboogaard 2012; E Kinoshita 2013, Caroline Bruinsma 2016, Carolien Bruin 2016, Agnese Loda 2016, Nathalie van Tempel 2017, Marti Borkent 2017, Marti Quevedo Calero 2018, Barbara Steuer, 2019, Alex Naegu 2020, Laura Brueckner 2021, Shuang Zhang, 2022, Helene Kabbech 2024), one at Wageningen University (Maureen Eijpe 2002), and one at Utrecht University (Margarida da Avo Ribeiro dos Santos 2013)
Grants
• ZONMW: Hipgametes: In vitro generation of human induced pluripotent stem cell derived gametes to model human embryogenesis. (2021-2026). €660.417,- Coapplicant, (total consortium grant: € 3.483.750,-).
• FP7-people-2011-ITN, Grant agreement number 289880. Marie Curie Initial Training network Reprotrain (2012-2016) €250.000,- Work package leader (complete grant €3.650.000,-).
• Netherlands Organization for Scientific Research (NWO-ALW), Open Program 819.02.020: Homology recognition and DNA double-strand break repair during meiosis (2010-2014) €249.013,- Project leader
864.05.003: Ubiquitination and epigenetic modifications: meiotic XY body chromatin dynamics (2005-2010) €600000 Project leader
COLLABORATIONS
National:
• Prof. dr. Adriaan Houtsmuller Erasmus MC, Nanoscopic analyses of chromosome pairing and DNA double-strand break repair in meiosis
• Dr. Gert Dohle and Dr. Marij Smit, Erasmus MC, Analyses of male infertility
• Dr. Esther Baart Erasmus MC, Sperm quality
• Prof. dr Roland kanaar/dr Alex Zelensky, Erasmus MC, DNA repair in meiosis
• Prof. dr. Ans van Pelt (AMC), Dr. Susana Chuva de Sousa Lopes (LUMC), Prof.
• Dr. N. Geijsen, in vitro gametogenesis
International:
• Prof. dr. Attila Toth, University of Dresden, Germany: Analyses of the role of HORMAD proteins in chromosome pairing and DNA double-strand break repair during meiosis
• dr. Gabriel Marais, Université Lyon 1, CNRS, Villeurbanne, France: Identification of sex-determining gene in Ellobius Lutescens
• Prof. dr. Csilla Krausz, University of Florence, Italy: Characterization of meiotic infertility phenotype in patients with identified genetic mutation
• Prof. Marco Barchi, University of Rome, Italy: Analyses of recombinase functions in meiosis
Management, coordination and development of teaching courses:
Dr. Baarends coordinated the course Developmental Evolutionary Biology (2nd year Bachelor Nanobiology from 2014-2019). She also coordinate(d) the courses entitled “Writing a project proposal (2014-2022)”, “Report writing (2015-present)”, and “Presentation skills (2014-present)” that are offered to students of the Molecular Medicine Master of Science program. Since 2020 she is the coordinator of year 1 of this program. From 2016-2022 she also coordinated and teached the course “Writing a project proposal” for the Master program Nanobiology. Since 2017 she coordinates the Erasmus Querido Honours Program (together with dr. David van de Vijver and dr. Jeroen de Jonge), that allows excellent Medicine students (Bachelor) to deepen and broaden their knowledge, develop soft skills, and perform research. The aim is to further professionalize the program, (re)define learning aims,and add new items to the program in order to stimulate research skills, and optimally
connect to the Research Masters. She is faculty member of the Master Nanobiology and the Research Master Molecular Medicine. She was member of the teaching committee of the Bachelor Nanobiology from 2015-2019 She was involved in management of the Corona Research Super Project; an initiative of the Nanobiology Faculty (Erasmus MC-TU Delft), initiated in response to the lockdown of all lab research in March 2020, to join forces of students from different disciplines to help tackle research questions related to the COVID-19 pandemic in different group projects that exchange results with each other to enable “community learning”. See:https://www.eur.nl/en/erasmusmc/research/corona-research-superproject/ project-information-contact. She supervised one group and is co-author on a short paper entitled "The Corona Research Super Project: a virtual transdisciplinary research project" that was published in The Electronic Journal for Research in Science & Mathematics Education (https://ejrsme.icrsme.com/article/view/20482).
List of teaching activites
• One lecture and Integrative skills session on sex differentiation for 1st year
medical students (since 2015)
• Lecture on gametogenesis for 3rd year medical students (since 2003)
• Two sessions Integrative skills and two self-study assignments on reproduction and development for 3rd year medical students (since 2003)
• 6 interactive lectures in the course Evolutionary Developmental Biology for 2nd year Nanobiology (Erasmus MC-TU Delft) students, and 4 instruction sessions in this course to guide the students during preparation of a poster (developed by myself, since 2014).
• Two lectures in the course Report writing (Research master Molecular Medicine, Erasmus MC), and evaluation and final grading of the research reports (since 2015).
• Two lectures in the course Proposal writing (Research master Molecular Medicine, Erasmus MC, and Master Nanobiology, Erasmus MC-TU Delft), and final evaluation and grading of proposals (2014-2022).
• One lecture in Contemporary Research Topics in the Research Master Molecular medicine, Erasmus MC (2008-2019).
• One lecture in Developmental Biology Course in the Research Master Molecular medicine, Erasmus MC (since 2008).
• One lecture in the Molecular Biology of the Cell course in the Research Master Molecular medicine, Erasmus MC (2008-2021).
• 3 interactive sessions in the course Presentation skills in the Research Master Molecular medicine, Erasmus MC (since 2014).
• Different interactive lectures (Biomedical literature discussion, how to write a scientific essay (three sessions including peer review), how to find a research project and define personal learning aims) to Querido Honours College students and one integrative skills session on basic techniques in biomedicine each year
• Supervision of Bachelor (Nanobiology (8 Projects between 2016-2024) and Master of Science (different programs, 13 projects between 2011-2024) students during research Bachelor and Master end project.
Research Management
As a group-leader, She presently supervises and coordinates the activities of one technician, and five PhD students. In addition, Bachelor and Master of Science students regularly perform 3 (Bachelor), 6 or 12-month (Master) research projects in her group (Currently two Bachelor and one Master students Nanobiology). She coordinates the teaching activities of our Department. She is the contact person and coordinator for all animal experiments within the Department of Developmental Biology. She replaces the head of the Department in his absence, and co-supervise the lab manager.
International activities
External, advisory committees, reviewer, etc.:
• Member of the Review Committee of the DFG (German Science Foundation) priority program: Mechanisms of Genome Haploidization (2009-2015)
• Dr Baarends reviewed several grant proposals for the German DFG, the French ANR, and the Polish NCN
• Member of the European scientific coordination network (GDRE) Mammalian Meiosis. (2011-2018), this network aimed to promote interactions and collaborations between European groups, leaders in the field of mammalian meiosis.
• Member of the Transregional Collaborative Research Centre 81, entitled Chromatin Changes in Differentiation and Malignancies (CCDM). This is a collaboration between Justus-Liebig-University Giessen, Philipps-University Marburg, Erasmus MC Rotterdam, and Max-Planck-Institute Bad Nauheim. The overlapping aim of the research performed by the groups that form the network
is to understand the molecular function of chromatin.
• Member of management committee of ANDRONET cost action (European Andrology network-research coordination, education and public awareness 2021-
2025)
• Dr Baarends is acting as reviewer for a number of international journals, including: PLOS Genetics, Biology of Reproduction, Human Reproduction, Chromosoma, Journal of Cell Science, DNA Repair, EMBO Journal, Epigenetics & Chromatin, Nature Communications, New England Journal of medicine, and Development.
• She has acted as guest editor for PLOS Genetics several times.
Societal Significance of Research:
The results obtained in this project may help to improve the decision making in issues regarding male fertility. Her group recently observed that a significant proportion of male patients with defects in meiotic prophase progression do not have a complete meiotic arrest (ongoing studies). Thus, such patients could be at risk of generating sperm with a damaged genome, which warrants careful evaluation in the context of the application of assisted reproductive techniques (ART). The presence of persistent damage or a high frequency of chromosome pairing abnormalities, which in particular may involve the sex chromosomes, could be indicative for a higher chance of transmitting an incomplete or damaged genome to the next generation. Although there is little discussion about possible risks associated with the use of ART, such as intracytoplasmic sperm injection (ICSI), available results from human follow-up studies after ART, as well as animal models, indicate that such an evaluation is desirable. Any clinically important data (potential biomarkers for germ cell cancer, potential sperm quality parameters, potential improvement of ART risk assessment) coming out of her research projects, will immediately be shared within the relevant ACE within Erasmus MC (Pregnancy and Childhood, MolBiM, Urogenital Tumors) which will increase the chance that useful assays will be developed in follow-up projects. In the context of a broader general public, she has contributed to the “sexy chromosomes” project initiated within our Department (Prof. JA Grootegoed) to join in the competition for the “Academische jaarprijs” in 2007, the material was later used in our teaching. In addition, she contributed to an article in the daily newspaper “Trouw” on the role of androgens in determining the difference between men and women in sports (https://www.trouw.nl/nieuws/er-zijn-twee-categorieen-mensen-zij-die-denkendat-er-vrouwen-en-mannen-zijn-en-zij-die-beterweten~b12bb90f/?referrer=https%3A%2F%2Fwww.google.nl%2F) in May 2019, as well as in the student journal Algemeen Nijmeegs Studentenblad (April 2020, https://issuu.com/ans-online/docs/ans6_op_stal). She also explained her research topic to the general public in an Article in “Algemeen Dagblad”, the regional (Gouda) edition (March, 2022)(https://www.destentor.nl/gezond/willy-wil-de-perfecte-zaadcelen-
eicel-maken-in-een-kweekbakje-we-willen-gezondekinderen~ ad46cc8a/?referrer=https%3A%2F%2Fwww.google.nl%2F). Recently (June 2023), She was interviewed for the national newspaper NRC Handelsblad for an article on Ellobius Lutescens and how it may have lost its Y chromosome (https://www.nrc.nl/nieuws/2023/06/09/het-einde-van-y-of-hoe-een-woelmuis-kanleven-zonder-mannelijk-geslachtschromosoom-a4166588). Finally, the Hipgametes consortium, was nominated for the Klokhuisprijs, and contributed to an event during which 2 of her PhD students explained aspects of sperm and egg formation to elementary school children (https://nl.linkedin.com/posts/erasmus-mc_klokhuiswetenschapsprijs-wetenschapsprijs-activity-7172870386672476160-jX1X)
Invited/selected lectures
• EMBO workshop on meiosis, June 2023, Pamhagen, Austria
• Meiotic Encounters, June 2023, Prague, Czech Republic
• Deciphering the genetic basis of inheritance: from gametogenesis to reproductive
diseases, International Symposium Fundación Ramon Areces, Salamanca, July 7th-
8th, 2020 (canceled due to COVID-19 pandemic)
• 5th TRR81 Symposium, Sept 2019, Bad Nauheim, Germany
• EMBO workshop on meiosis, August 2019,La Rochelle, France
• 9th European Congress of Andrology, September 2016, Rotterdam, the Netherlands
• Mechanisms of genome haploidization SPP1384 Meiosis Meeting, Oct 2015,
Dresden, Germany
• EMBO conference on meiosis, August-September 2015, Oxford, United Kingdom
• ESHRE annual meeting, June 2015, Lisbon Portugal
• 8th INYRMF (International Network for Young Researchers in Male Fertility) meeting,
May 14th-16th 2015, Florence, Italy
• 20th Nederlands-Vlaams Doelencongres Infertiliteit, Gynaecologie en Obstetrie, April
22-24 2015, Rotterdam, The Netherlands
• 9th Biomedical Student Symposium, of Genes and Genesis, a glimpse into
developmental Biology, Oct 30th-November 2nd, 2014 Erlangen, Germany
• von-Behring-Röntgen Symposium 2013: Key Mechanisms in the Regulation of the
Testis Function, April 2013, Giessen, Germany
• 3rd annual Epigenetics Europe 2012 conference, September 2012, Frankfurt,
Germany
• 2nd EMBO Conference on Meiosis, September 2011, Capaccio Paestum Italy
• 6th European Congress of Andrology (ECA), September/October 2010, Athens,
Greece
• Symposium: Meeting Pairing and Propagating, September 2010, Vienna, Austria
• 16th European Workshop on Molecular and Cellular Endocrinology of the Testis, May
2010, La Biodola, Island of Elba, Italy
• EMBO Meeting, August/September 2009, Amsterdam, The Netherlands
• 8th European Meiosis Meeting, September 2007, Shonan Village, Hayama,
Kanagawa, Japan
• British Society of Cell Biology Autumn Meeting: Cell Cycle Regulation of Meiosis,
September 2004, Newcastle Upon Tyne, UK
• 13th European Workshop on Molecular and Cellular Endocrinology of the Testis, April
2004, Dunblane, Scotland
• XVIIth Testis Workshop of the American Society of Andrology, Functional Genomics
of Male Reproduction, March 2003, Phoenix, AZ, USA
• 12th European Testis Workshop, April 2002, Doorwerth, The Netherlands
• Second Meiosis and Germ-Line Differentiation Meeting, September/October 2001,
Roscoff, France
LIST OF PUBLICATIONS
- International (refereed) journals
1. Koornneef L, Paul MW, Houtsmuller AB, Baarends WM, Slotman JA (2023). Threecolor
dSTORM Imaging and Analysis of Recombination Foci in Mouse Spread Meiotic
Nuclei. Bio Protoc. 13(14):e4780.
2. Boers R, Boers J, Tan B, van Leeuwen ME, Wassenaar E, Sanchez EG, Sleddens E,
Tenhagen Y, Mulugeta E, Laven J, Creyghton M, Baarends WM, van IJcken WFJ,
Gribnau J (2023). Retrospective analysis of enhancer activity and transcriptome
history. Nat Biotechnol. doi: 10.1038/s41587-023-01683-1. Epub ahead of print.
PMID: 36823354.
3. Key J, Gispert S, Koornneef L, Sleddens-Linkels E, Kohli A, Torres-Odio S, Koepf G,
Amr S, Reichlmeir M, Harter PN, West AP, Münch C, Baarends WM, Auburger G
(2022). CLPP Depletion Causes Diplotene Arrest; Underlying Testis Mitochondrial
Dysfunction Occurs with Accumulation of Perrault Proteins ERAL1, PEO1, and HARS2.
Cells. 12(1):52.
4. Koornneef L, Slotman JA, Sleddens-Linkels E, van Cappellen WA, Barchi M, Tóth A,
Gribnau J, Houtsmuller AB, Baarends WM (2022). Multi-color dSTORM microscopy
in Hormad1-/- spermatocytes reveals alterations in meiotic recombination
intermediates and synaptonemal complex structure. PLoS Genet. 18(7):e1010046.
5. Ghouil R, Miron S, Koornneef L, Veerman J, Paul MW, Le Du MH, Sleddens-Linkels E,
van Rossum-Fikkert SE, van Loon Y, Felipe-Medina N, Pendas AM, Maas A, Essers J,
Legrand P, Baarends WM, Kanaar R, Zinn-Justin S, Zelensky AN (2021) BRCA2
binding through a cryptic repeated motif to HSF2BP oligomers does not impact
meiotic recombination. Nature Commun 12(1): 4605
6. Mhaskar AN, Koornneef L, Zelensky AN, Houtsmuller AB, Baarends WM (2021) High
Resolution View on the Regulation of Recombinase Accumulation in Mammalian
Meiosis. Front. Cell Dev. Biol. 9:672191
7. Dereli, I, Stanzione, M, Olmeda, F, Papanikos, F, Baumann, M, Demir, S, Carofiglio,
F, Lange, J, de Massy, B, Baarends, WM, Turner, J, Rulands, S, Tóth, A (2021)
Four-pronged negative feedback of DSB machinery in meiotic DNA-break control in
mice. Nucleic Acids Res. Feb 22;gkab082. doi: 10.1093/nar/gkab082.
8. Krausz, C, Riera-Escamilla, A, Moreno-Mendoza, D, Holleman, K, Cioppi, C, Algaba,
F, Pybus, M, Friedrich, C, Wyrwoll, MJ, Casamonti, E, Pietroforte, S, Nagirnaja, L,
Lopes, AM, Kliesch, S, Pilatz, A, Carrell, DT, Conrad, DF, Ars, E, Ruiz-Castañé, E,
Aston, KI, Baarends, WM*, Tüttelmann F* (*shared last authors) 2020 Genetic
dissection of spermatogenic arrest through exome analysis: clinical implications for
the management of azoospermic men, Genet Med, Dec;22(12):1956-1966
9. Slotman, JA, Paul, MW, Carofiglio, F, Vergroesen, T, Koornneef, L, van Cappellen,
WA, Houtsmuller, AB, and Baarends, WM (2020) Super-resolution imaging of
RAD51 and DMC1 in DNA repair foci reveals dynamic distribution patterns in meiotic
prophase, PloS Genet, 16(6)e1008595
10. Enguita-Marruedo, A, Sleddens-Linkels, E, Ooms ,M, de Geus, V, Wilke, M, Blom, E,
Dohle, GR, Looijenga, LHJ, van Cappellen, W, Baart, EB, and Baarends, WM.
(2019) Meiotic arrest occurs most frequently at metaphase and is often incomplete
in azoospermic men, Fertility and Sterility, Dec;112(6):1059-1070.e3
11. Brandsma, I, Sato, K, van Rossum-Fikkert, SE, van Vliet, N, Sleddens, E, Reuter, M,
Odijk, H, van den Tempel, N, Dekkers, DHW, Bezstarosti, K, Demmers, JAA, Maas,
A, Lebbink, J, Wyman, C, Essers, J, van Gent, DC, Baarends, WM, Knipscheer, P,
Kanaar, R, and Zelensky, AN.(2019) HSF2BP Interacts with a Conserved Domain of
BRCA2 and Is Required for Mouse Spermatogenesis, Cell reports 27, 3790-3798
e3797.
12. Riera-Escamilla, A, Enguita-Marruedo, A, Moreno-Mendoza, D, Chianese, C,
Sleddens-Linkels, E, Contini, E, Benelli, M, Natali, A, Colpi, GM, Ruiz-Castane, E,
Maggi, M, Baarends, WM, and Krausz, C (2019) Sequencing of a 'mouse
azoospermia' gene panel in azoospermic men: identification of RNF212 and STAG3
mutations as novel genetic causes of meiotic arrest, Human reproduction 34, 978-
988.
13. Paul, MW, de Gruiter, HM, Lin, Z, Baarends, WM, van Cappellen, WA, Houtsmuller,
AB, and Slotman, JA (2019) SMoLR: visualization and analysis of single-molecule
localization microscopy data in R, BMC Bioinformatics 20, 30.
14. Magaraki, A, Loda, A, Gontan, C, Merzouk, S, Sleddens-Linkels, E, Meek, S,
Baarends, WM, Burdon, T, and Gribnau, J (2019) A novel approach to differentiate
rat embryonic stem cells in vitro reveals a role for RNF12 in activation of X
chromosome inactivation, Sci Rep 9, 6068.
15. Enguita-Marruedo, A, Van Cappellen, WA, Hoogerbrugge, JW, Carofiglio, F,
Wassenaar, E, Slotman, JA, Houtsmuller, A, and Baarends, WM (2018) Live cell
analyses of synaptonemal complex dynamics and chromosome movements in
cultured
16. Carofiglio, F., Sleddens-Linkels, E., Wassenaar, E., Inagaki, A., van Cappellen, W. A.,
Grootegoed, J. A., Toth, A. and Baarends, WM (2018). Repair of exogenous DNA
double-strand breaks promotes chromosome synapsis in SPO11-mutant mouse
meiocytes, and is altered in the absence of HORMAD1. DNA Repair (Amst) 63, 25-
38.
17. Magaraki A, van der Heijden G, Sleddens-Linkels E, Magarakis L, van Cappellen WA,
Peters AH, Gribnau J, Baarends WM & Eijpe M 2017 Silencing markers are retained
on pericentric heterochromatin during murine primordial germ cell development.
Epigenetics Chromatin 10 11.
18. Federici F, Magaraki A, Wassenaar E, van Veen-Buurman CJH, van de Werken C,
Baart E, Laven JSE, Grootegoed JA, Gribnau J, and Baarends WM (2016) Round
spermatid injection rescues female lethality of a paternally inherited Xist deletion in
mouse. PLOS Genetics, 12 e1006358
19. Mulugeta E, Wassenaar E, Sleddens-Linkels E, van IWF, Heard E, Grootegoed, JA,
Just, W, Gribnau, J, and Baarends WM. (2016) Genomes of Ellobius species provide
insight into the evolutionary dynamics of mammalian sex chromosomes. Genome
Res 26: 1202-1210.
20. Bruinsma CF, Savelberg SM, Kool MJ, Jolfaei MA, Van Woerden GM, Baarends WM,
Elgersma Y (2016) An essential role for UBE2A/HR6A in learning and memory and
mGLUR-dependent long-term depression. Hum Mol Genet 25: 1-8.
21. Uringa EJ, Baldeyron C, Odijk H, Wassenaar E, van Cappellen WA, Maas A,
Hoeijmakers JH, Baarends WM, Kanaar R, Essers J (2015) A mRad51-GFP
antimorphic allele affects homologous recombination and DNA damage sensitivity.
DNA Repair (Amst) 25: 27-40.
22. Federici F, Mulugeta E, Schoenmakers S, Wassenaar E, Hoogerbrugge JW, van der
Heijden GW, van Cappellen WA, Slotman JA, van IJcken WF, Laven JS, Grootegoed
JA, Baarends WM (2015) Incomplete meiotic sex chromosome inactivation in the
domestic dog. BMC Genomics 16: 291.
23. van de Werken C, van der Heijden GW, Eleveld C, Teeuwssen M, Albert M, Baarends
WM, Laven JS, Peters AH, Baart EB (2014) Paternal heterochromatin formation in
human embryos is H3K9/HP1 directed and primed by sperm-derived histone
modifications. Nat Commun 5: 5868.
24. Bergs JW, Neuendorff N, van der Heijden G, Wassenaar E, Rexin P, Elsässer HP, Moll
R, Baarends WM, Brehm A. (2014) Differential expression and sex chromosome
association of CHD3/4 and CHD5 during spermatogenesis. PLoS One 9: e98203.
25. Carofiglio, F, A Inagaki, S de Vries, E Wassenaar, S Schoenmakers, C Vermeulen,
WA van Cappellen, E Sleddens-Linkels, JA Grootegoed, H te Riele, B de Massy, and
WM Baarends, SPO11-independent DNA Repair Foci and Their Role in Meiotic
Silencing. PLoS Genet, 2013. 9(6): p. e1003538.
26. Shang, P, J Hoogerbrugge, WM Baarends, and JA Grootegoed, Evolution of testisspecific
kinases TSSK1B and TSSK2 in primates. Andrology, 2013. 1(1): p. 160-8.
27. Inagaki, A, E Sleddens-Linkels, E Wassenaar, M Ooms, WA van Cappellen, JH
Hoeijmakers, J Seibler, TF Vogt, MK Shin, JA Grootegoed, and WM Baarends,
Meiotic functions of RAD18. J Cell Sci, 2011. 124(Pt 16): p. 2837-50.
28. Inagaki, A, E Sleddens-Linkels, WA van Cappellen, RG Hibbert, TK Sixma, JH
Hoeijmakers, JA Grootegoed, and WM Baarends, Human RAD18 Interacts with
Ubiquitylated Chromatin Components and Facilitates RAD9 Recruitment to DNA
Double Strand Breaks. PLoS One, 2011. 6(8): p. e23155
29. Shang, P, WM Baarends, J Hoogerbrugge, MP Ooms, WA van Cappellen, AA de
Jong, GR Dohle, H van Eenennaam, JA Gossen, and JA Grootegoed, Functional
transformation of the chromatoid body in mouse spermatids requires testis-specific
serine/threonine kinases. J Cell Sci, 2010. 123(Pt 3): p. 331-9.
30. Schoenmakers, S, E Wassenaar, JS Laven, JA Grootegoed, and WM Baarends,
Meiotic silencing and fragmentation of the male germline restricted chromosome in
zebra finch. Chromosoma, 2010. 119: p. 311-324.
31. Mulugeta Achame, E, WM Baarends, J Gribnau, and JA Grootegoed, Evaluating the
relationship between spermatogenic silencing of the X chromosome and evolution of
the Y chromosome in chimpanzee and human. PLoS One, 2010. 5(12): p. e15598.
32. Mulugeta Achame, E, E Wassenaar, JW Hoogerbrugge, E Sleddens-Linkels, M Ooms,
ZW Sun, IWF van, JA Grootegoed, and WM Baarends, The ubiquitin-conjugating
enzyme HR6B is required for maintenance of X chromosome silencing in mouse
spermatocytes and spermatids. BMC Genomics, 2010. 11: p. 367.
33. Schoenmakers, S, E Wassenaar, JW Hoogerbrugge, JS Laven, JA Grootegoed, and
WM Baarends, Female meiotic sex chromosome inactivation in chicken. PLoS
Genet, 2009. 5(5): p. e1000466.
34. Inagaki, A, WA van Cappellen, R van der Laan, AB Houtsmuller, JH Hoeijmakers, JA
Grootegoed, and WM Baarends, Dynamic localization of human RAD18 during the
cell cycle and a functional connection with DNA double-strand break repair. DNA
Repair (Amst), 2009. 8(2): p. 190-201.
35. Schoenmakers, S, E Wassenaar, WA van Cappellen, AA Derijck, P de Boer, JS Laven,
JA Grootegoed, and WM Baarends, Increased frequency of asynapsis and
associated meiotic silencing of heterologous chromatin in the presence of irradiationinduced
extra DNA double strand breaks. Dev Biol, 2008. 317: p. 270-281.
36. Rathke, C, WM Baarends, S Jayaramaiah-Raja, M Bartkuhn, R Renkawitz, and R
Renkawitz-Pohl, Transition from a nucleosome-based to a protamine-based
chromatin configuration during spermiogenesis in Drosophila. J Cell Sci, 2007.
120(Pt 9): p. 1689-700.
37. Baarends, WM, E Wassenaar, JW Hoogerbrugge, S Schoenmakers, ZW Sun, and JA
Grootegoed, Increased phosphorylation and dimethylation of XY body histones in the
Hr6b-knockout mouse is associated with derepression of the X chromosome. J Cell
Sci, 2007. 120(Pt 11): p. 1841-51.
38. Wesoly, J, S Agarwal, S Sigurdsson, W Bussen, S Van Komen, J Qin, H van Steeg, J
van Benthem, E Wassenaar, WM Baarends, M Ghazvini, AA Tafel, H Heath, N
Galjart, J Essers, JA Grootegoed, N Arnheim, O Bezzubova, JM Buerstedde, P Sung,
and R Kanaar, Differential contributions of mammalian Rad54 paralogs to
recombination, DNA damage repair, and meiosis. Mol Cell Biol, 2006. 26(3): p. 976-
89.
39. Liebe, B, G Petukhova, M Barchi, M Bellani, H Braselmann, T Nakano, TK Pandita, M
Jasin, A Fornace, ML Meistrich, WM Baarends, J Schimenti, T de Lange, S Keeney,
RD Camerini-Otero, and H Scherthan, Mutations that affect meiosis in male mice
influence the dynamics of the mid-preleptotene and bouquet stages. Exp Cell Res,
2006. 312(19): p. 3768-81.
40. de Vries, FA, E de Boer, M van den Bosch, WM Baarends, M Ooms, L Yuan, JG Liu,
AA van Zeeland, C Heyting, and A Pastink, Mouse Sycp1 functions in synaptonemal
complex assembly, meiotic recombination, and XY body formation. Genes Dev, 2005.
19(11): p. 1376-89.
41. Baarends, WM, E Wassenaar, R van der Laan, JW Hoogerbrugge, E Sleddens-
Linkels, JH Hoeijmakers, P de Boer, and JA Grootegoed, Silencing of unpaired
chromatin and histone H2A ubiquitination in mammalian meiosis. Molecular and
Cellular Biology, 2005. 25: p. 1041-1053.
42. van der Laan, R, EJ Uringa, E Wassenaar, JW Hoogerbrugge, E Sleddens, H Odijk, HP
Roest, P de Boer, JH Hoeijmakers, JA Grootegoed, and WM Baarends, Ubiquitin
ligase Rad18Sc localizes to the XY body and to other chromosomal regions that are
unpaired and transcriptionally silenced during male meiotic prophase. J Cell Sci,
2004. 117(Pt 21): p. 5023-33.
43. Siep, M, E Sleddens-Linkels, S Mulders, H van Eenennaam, E Wassenaar, WA van
Cappellen, JW Hoogerbrugge, JA Grootegoed, and WM Baarends, Basic helix-loophelix
transcription factor Tcfl5 interacts with the Calmegin gene promoter in mouse
spermatogenesis. Nucleic Acids Research, 2004. 32(21):6425-36.
44. Roest, HP, WM Baarends, J de Wit, JW van Klaveren, E Wassenaar, JW
Hoogerbrugge, WA van Cappellen, JH Hoeijmakers, and JA Grootegoed, The
ubiquitin-conjugating DNA repair enzyme HR6A is a maternal factor essential for
early embryonic development in mice. Mol Cell Biol, 2004. 24(12): p. 5485-95.
45. Baarends, WM, E Wassenaar, JW Hoogerbrugge, G van Cappellen, HP Roest, J
Vreeburg, M Ooms, JH Hoeijmakers, and JA Grootegoed, Loss of HR6B ubiquitinconjugating
activity results in damaged synaptonemal complex structure and
increased crossing-over frequency during the male meiotic prophase. Mol Cell Biol,
2003. 23(4): p. 1151-62.
46. van Baren, MJ, HC van der Linde, GJ Breedveld, WM Baarends, P Rizzu, E de
Graaff, BA Oostra, and P Heutink, A double RING-H2 domain in RNF32, a gene
expressed during sperm formation. Biochem Biophys Res Commun, 2002. 292(1):
p. 58-65. IF 2.6
47. van der Laan, R, H Roest, J Hoogerbrugge, E Smit, R Slater, WM Baarends, J
Hoeijmakers, and J Grootegoed, Characterization of mRAD18Sc, a mouse homolog of
the yeast post-replication repair gen RAD18. Genomics, 2000. 69(1): p. 86-94.
48. Lampa, J, JW Hoogerbrugge, WM Baarends, PG Stanton, KJ Perryman, JA
Grootegoed, and DM Robertson, Follicle-stimulating hormone and testosterone
stimulation of immature and mature Sertoli cells in vitro: inhibin and N-cadherin
levels and round spermatid binding. J Androl, 1999. 20(3): p. 399-406.
49. Baarends, WM, JW Hoogerbrugge, HP Roest, M Ooms, J Vreeburg, JHJ
Hoeijmakers, and JA Grootegoed, Histone ubiquitination and chromatin remodeling in
mouse spermatogenesis. Dev. Biol., 1999. 207: p. 322-333.
50. Roijen van, JH, MP Ooms, M Spaargaren, WM Baarends, RFA Weber, JA
Grootegoed, and JTM Vreeburg, Immunoexpression of testis-specific histone 2B
(TH2B) in human spermatozoa and testis tissue. Hum. Reprod., 1998. 13: p. 1559-
1566.
51. Rijkers, T, J Van Den Ouweland, B Morolli, AG Rolink, WM Baarends, PP Van Sloun,
PH Lohman, and A Pastink, Targeted inactivation of mouse RAD52 reduces
homologous recombination but not resistance to ionizing radiation. Mol Cell Biol,
1998. 18(11): p. 6423-9.
52. Hendriksen, PJM, JW Hoogerbrugge, WM Baarends, Pd Boer, JTM Vreeburg, EA Vos,
Tvd Lende, and JA Grootegoed, testis-specific expression of a functional retroposon
encoding glucose-6-phosphate dehydrogenase in the mouse. Genomics, 1997. 41:
p. 350-359.
53. Roest, HP, J Klaveren van, J Wit de, CG Gurp van, MHM Koken, M Vermey, JH Roijen
van, JTM Vreeburg, WM Baarends, D Bootsma, JA Grootegoed, and JHJ
Hoeijmakers, Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in
mice causes a defect in spermatogenesis associated with chromatin modification.
Cell, 1996. 86: p. 799-810.
54. Slegtenhorst-Eegdeman, KE, M Post, WM Baarends, AP Themmen, and JA
Grootegoed, Regulation of gene expression in Sertoli cells by follicle-stimulating
hormone (FSH): cloning and characterization of LRPR1, a primary response gene
encoding a leucine-rich protein. Mol Cell Endocrinol, 1995. 108: p. 115-24.
55. Baarends, WM, JTJ Uilenbroek, P Kramer, JW Hoogerbrugge, ECM Van Leeuwen,
APN Themmen, and JA Grootegoed, Anti-müllerian hormone and anti-müllerian
hormone type II receptor messenger ribonucleic acid expression in rat ovaries during
postnatal development, the estrous cycle, and gonadotropin-induced follicle growth.
Endocrinology, 1995. 136: p. 4951-4962.
56. Baarends, WM, JW Hoogerbrugge, M Post, JA Visser, DG De Rooij, M Parvinen, APN
Themmen, and JA Grootegoed, Anti-müllerian hormone and anti-müllerian hormone
type II receptor messenger ribonucleic acid expression during postnatal testis
development and in the adult testis of the rat. Endocrinology, 1995. 136: p. 5614-
5622.
57. Gao, X, GA Kuiken, WM Baarends, JG Koster, and OH Destree, Characterization of
a functional promoter for the Xenopus wnt-1 gene on vivo. Oncogene, 1994. 9(2): p.
573-81.
58. Eizema, K, JG Koster, BI Stegeman, WM Baarends, PH Lanser, and OH Destree,
Comparative analysis of Engrailed-1 and Wnt-1 expression in the developing central
nervous system of Xenopus laevis. Int J Dev Biol, 1994. 38(4): p. 623-32.
59. Baarends, WM, MJL Van Helmond, M Post, PJCM Van der Schoot, JW Hoogerbrugge,
JP De Winter, JTJ Uilenbroek, B Karels, LG Wilming, JHC Meijers, APN Themmen, and
JA Grootegoed, A novel member of the transmembrane serine/threonine kinase
receptor family is specifically expressed in the gonads and in mesenchymal cells
adjacent to the müllerian duct. Development, 1994. 120: p. 189-197.
60. Blok, LJ, JW Hoogerbrugge, AP Themmen, WM Baarends, M Post, and JA
Grootegoed, Transient down-regulation of androgen receptor messenger ribonucleic
acid (mRNA) expression in Sertoli cells by follicle-stimulating hormone is followed by
up-regulation of androgen receptor mRNA and protein. Endocrinology, 1992.
131(3): p. 1343-9.
61. Blok, LJ, AP Themmen, AH Peters, J Trapman, WM Baarends, JW Hoogerbrugge,
and JA Grootegoed, Transcriptional regulation of androgen receptor gene expression
in Sertoli cells and other cell types. Mol Cell Endocrinol, 1992. 88(1-3): p. 153-64.
62. Boerjan, ML, WM Baarends, and HJ Ruven, A cytochemical staining procedure for
succinate dehydrogenase activity in pre-ovulatory mouse oocytes embedded in low
gelling temperature agarose. J Histochem Cytochem, 1991. 39(1): p. 135-8.
63. Faber, PW, HC van Rooij, HA van der Korput, WM Baarends, AO Brinkmann, JA
Grootegoed, and J Trapman, Characterization of the human androgen receptor
transcription unit. J Biol Chem, 1991. 266(17): p. 10743-9.
64. Themmen, AP, LJ Blok, M Post, WM Baarends, JW Hoogerbrugge, M Parmentier, G
Vassart, and JA Grootegoed, Follitropin receptor down-regulation involves a cAMPdependent
post- transcriptional decrease of receptor mRNA expression. Mol Cell
Endocrinol, 1991. 78(3): p. R7-13.
65. Baarends, WM, AP Themmen, LJ Blok, P Mackenbach, AO Brinkmann, D Meijer, PW
Faber, J Trapman, and JA Grootegoed, The rat androgen receptor gene promoter.
Mol Cell Endocrinol, 1990. 74(1): p. 75-84.
Books, or contributions to books
1. Magaraki, A, Loda, A, Gribnau, J, and Baarends, WM (2018) Simultaneous RNA-DNA FISH
in Mouse Preimplantation Embryos, Methods in molecular biology 1861, 131-147.
2. Schoenmakers, S and WM Baarends, Meiotic pairing of homologous chromosomes and
silencing of heterologous regions, in Epigenetics and human reproduction, S. Rousseaux
and S. Khochbin, Editors. 2011, Springer-verlag: Heidelberg. p. 157-186.
3. Baarends, WM and JA Grootegoed, Male gametogenesis, in Reproductive Medicine,
Molecular, Cellular and Genetic Fundamentals, BCJM Fauser, Editor. 2003, Parthenon
Publishing Group Inc.: New York. p. 381-399.
4. Baarends, WM and JA Grootegoed, Molecular biology of male gametogenesis, in
Molecular Biology in Reproductive Medicine, B.C.J.M. Fauser, Editor. 1999, Parthenon
Publishing Group Inc.: New York. p. 271-295.
5. Baarends, WM, HP Roest, JW Hoogerbrugge, PJM Hendriksen, JHJ Hoeijmakers, and JA
Grootegoed, Chromatin structure and gene expression during spermatogenesis, in Testicular function: from gene expression to genetic manipulation, M. Stefanini, et al.,
Editors. 1998, Springer-Verlag: Berlin. p. 83-103
- Other: Invited reviews
1) Rathke, C, Baarends, WM, Awe, S, Renkawitz-Pohl, R Chromatin dynamics during
spermiogenesis. BBA - Gene Regul Mech, 2013. Sep 30. doi:pii: S1874-9399(13)00138-7.
10.1016/j.bbagrm.2013.08.004.
2) van der Heijden, GW, M Eijpe, and WM Baarends, The X and Y chromosomes in meiosis:
how and why they keep silent. Asian J Androl, 2011. 13(6): p. 779-780.
3) Inagaki, A, S Schoenmakers, and WM Baarends, DNA double strand break repair,
chromosome synapsis and transcriptional silencing in meiosis. Epigenetics, 2010. 5(4): p.
255-66.
4) Baarends, WM and R Mercier, Sisters dancing in meiosis. EMBO Rep, 2010. 11(2): p.
76-8.
5) van der Laan, R, WM Baarends, E Wassenaar, HP Roest, JH Hoeijmakers, and JA
Grootegoed, Expression and possible functions of DNA lesion bypass proteins in
spermatogenesis. Int J Androl, 2005. 28(1): p. 1-15.
6) Baarends, WM and JA Grootegoed, Chromatin dynamics in the male meiotic prophase.
Cytogenet Genome Res, 2003. 103(3-4): p. 225-34.
7) Baarends, WM, R van der Laan, and JA Grootegoed, DNA repair mechanisms and
gametogenesis. Reproduction, 2001. 121: p. 31-39.
8) Grootegoed, JA, M Siep, and WM Baarends, Molecular and cellular mechanisms in
spermatogenesis. Baillieres Best Pract Res Clin Endocrinol Metab, 2000. 14(3): p. 331-
343.
9) Baarends, WM, R van der Laan, and JA Grootegoed, Specific aspects of the ubiquitin
system in spermatogenesis. J. Endocrinol. Invest., 2000. 23(9): p. 597-604.
10) Baarends, WM, HP Roest, and JA Grootegoed, The ubiquitin system in gametogenesis.
Mol Cell Endocrinol, 1999. 151(1-2): p. 5-16.
11) Grootegoed, JA, WM Baarends, HP Roest, and JH Hoeijmakers, Knockout mouse models
and gametogenic failure. Mol. Cell. Endocrinol., 1998. 145(1-2): p. 161-6.
12) Grootegoed, JA, WM Baarends, PJM Hendriksen, JW Hoogerbrugge, KE Slegtenhorst-
Eegdeman, and APN Themmen, Molecular and cellular events in spermatogenesis. Hum
Reprod, 1995. 10: p. 10-14.
13) Grootegoed, JA, WM Baarends, and APN Themmen, Welcome to the family: the anti-
Mullerian hormone receptor. Mol Cell Endocrinol, 1994. 100: p. 29-34.
April, 2024