PhD in MEDICAL-SURGICAL BIOTECHNOLOGIES AND TRANSLATIONAL MEDICINE

email: scioli@med.uniroma2.it
phone: 0620903940

Professional experience

10/09/2022 – to date: TAB personnel, category D, technical, technical-scientific and data processing, Anatomic Pathology Institute, Biomedicine and Prevention, University of Rome "Tor Vergata".

15/04/2011 – 01/07/2019: Post-doctoral Fellow, Anatomic Pathology Institute, Biomedicine and Prevention, University of Rome "Tor Vergata". Main fields of research: study of biological characteristics and regenerative properties of adult stem cells of adipose tissue, cardiovascular pathologies and oxidative stress.

01/12/2010 - 01/03/2011: Post-graduated fellowship, study of differentiation of human pre-adipocytes in response to growth factors, Anatomic Pathology Institute, Department of Biopathology and Image Diagnostics, University of Rome "Tor Vergata".

01/11/2007 - 31/10/2010: PhD Student Position in Advanced Technologies in Biomedicine, study of the biology of human adipose derived stem cells, Anatomic Pathology Institute, Department of Biomedicine and Prevention, University of Rome "Tor Vergata".

15/05/2007 - 31/12/2007: Scientific collaborator at the Anatomic Pathology Institute, Department of Biopathology and Image Diagnostics, University of Rome "Tor Vergata".

01/03/2006 - 30/04/2007: Stage at the Laboratory of Molecular Biology, Anatomic Pathology Institute, Department of Biopathology and Image Diagnostics, University of Rome "Tor Vergata".

01/06/2005 - 28/02/2006: Stage at the Laboratory of Clinical Molecular Biology, Laboratory Medicine, Department of Internal Medicine, University of Rome "Tor Vergata".

Education

12/07/2011: PhD in Advanced Technologies in Biomedicine, title of thesis “Adult adipose derived stem cells: biological characteristics and therapeutic potential, Anatomic Pathology Institute, Department of Biopathology and Image Diagnostics, University of Rome "Tor Vergata".

Session II A.Y. 2006/2007: Qualified as a Professional Biologist at the University of Rome "Tor Vergata".

27/09/2006: Degree in Medical, pharmaceutical and veterinary biotechnology, degree vote 110/110 cum laude, title of thesis "RT-PCR in situ: methodology development for the study of skin disease", Anatomic Pathology Institute, Department of Biopathology and Image Diagnostics, University of Rome "Tor Vergata".


Scientific skills and expertise

Stem cell differentiation, regenerative medicine, oxidative stress, vascular dysfunction, cellular biology and physiology, cytofluorimetric analysis, molecular biology, biochemistry, cell signaling, ultrastructural analysis, immunohistochemistry and immunofluorescence techniques.

Technical and scientific roles

Reviewer for the following journals:

- Stem Cell Translational Medicine
- Journal of Clinical & Experimental Pathology
- Journal of Cytology & Histology
- Acta Biomaterialia
- PloSONE
- IJMS
- Cells
- Journal of Cell Physiology
- Antioxidants
- Biomolecules

Prizes

Winner of “Sebastiano e Rita Raeli” university prize for “Best graduates of Tor Vergata University”.
Sebastiano e Rita Raeli (2007).


Scientific publications: 71 papers on international peer-reviewed journals, citations 3,430, h-index 31 (Scopus index)


Most relevant bibliography in regenerative medicine

1. Scioli MG, Storti G, Bielli A, Sanchez M, Scimeca M, Gimble JM, Cervelli V, Orlandi A. CD146 expression regulates osteochondrogenic differentiation of human adipose-derived stem cells. J Cell Physiol. 2022 Jan;237(1):589-602. doi: 10.1002/jcp.30506. Epub 2021 Jul 20.
2. Scioli MG, Bielli A, Gentile P, Cervelli V, Orlandi A. Combined treatment with platelet-rich plasma and insulin favors chondrogenic and osteogenic differentiation of human adipose-derived stem cells in 3D collagen scaffold. J Tissue Eng Regen Med. 2017 Aug;11(8):2398-2410. doi: 10.1002/term.2139. Epub 2016 Apr 14.
3. Scioli MG, Cervelli V, Arcuri G, Gentile P, Doldo E, Bielli A, Bonanno E, Orlandi A. High Insulin-Induced Down-Regulation of Erk-1/IGF-1R/FGFR-1 Signaling Is Required for Oxidative Stress-Mediated Apoptosis of Adipose-Derived Stem Cells. J Cell Physiol. 2014 Dec;229(12):2077-87. doi: 10.1002/jcp.24667. PubMed PMID: 24818995.
4. Scioli MG, Bielli A, Gentile P, Mazzaglia D, Cervelli V, Orlandi A. The biomolecular basis of adipogenic differentiation of adipose-derived stem cells. Int J Mol Sci. 2014 Apr 16;15(4):6517-26. doi: 10.3390/ijms15046517. PubMed PMID: 24743893; PubMed Central PMCID: PMC4013644.
5. Gentile P, Orlandi A, Scioli MG, Di Pasquali C, Bocchini I, Curcio CB, Floris M, Fiaschetti V, Floris R, Cervell V. A comparative translational study: the combined use of enhanced stromal vascular fraction and platelet-rich plasma improves fat grafting maintenance in breast reconstruction. Stem Cells Transl Med. 2012 Apr;1(4):341-51. doi: 10.5966/sctm.2011-0065. Epub 2012 Apr 13. PubMed PMID: 23197813; PubMed Central PMCID: PMC3659694.
6. Cervelli V, Scioli MG, Gentile P, Doldo E, Bonanno E, Spagnoli LG, Orlandi A. Platelet-rich plasma greatly potentiates insulin-induced adipogenic differentiation of human adipose-derived stem cells through a serine/threonine kinase Akt-dependent mechanism and promotes clinical fat graft maintenance. Stem Cells Transl Med. 2012 Mar;1(3):206-20. doi: 10.5966/sctm.2011-0052. Epub 2012 Mar 7. PubMed PMID: 23197780; PubMed Central PMCID: PMC3659852.
7. Cervelli V, Gentile P, De Angelis B, Calabrese C, Di Stefani A, Scioli MG, Curcio BC, Felici M, Orlandi A. Application of enhanced stromal vascular fraction and fat grafting mixed with PRP in post-traumatic lower extremity ulcers. Stem Cell Res. 2011 Mar;6(2):103-11. doi: 10.1016/j.scr.2010.11.003. Epub 2010 Nov 30. PubMed PMID: 21195687.
8. Cervelli V, Gentile P, Scioli MG, Grimaldi M, Casciani CU, Spagnoli LG, Orlandi A. Application of platelet-rich plasma in plastic surgery: clinical and in vitro evaluation. Tissue Eng Part C Methods. 2009 Dec;15(4):625-34. doi: 10.1089/ten.TEC.2008.0518. PubMed PMID: 19231923.