BIOGRAPHICAL SKETCH
NAME: Ignasi Roig Navarro, PhD
eRA COMMONS USER NAME (credential, e.g., agency login): N.A.
POSITION TITLE: Associate Professor
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.)
INSTITUTION AND LOCATION DEGREE
(if applicable)
Start Date
MM/YYYY Completion Date
MM/YYYY
FIELD OF STUDY
Universitat Autònoma de Barcelona, Spain BS 09/1994 02/1999 Biology
Universitat Autònoma de Barcelona. Spain PhD 09/1999 07/2005 Cell Biology
Memorial Sloan-Kettering Cancer Center, NY, USA Postdoctoral Fellow 02/2006 01/2010 Molecular Biology
A. Personal Statement
Dr. Ignasi Roig, an Associate Professor at the Universitat Autònoma de Barcelona, leads a distinguished research group focused on mammalian gametogenesis. With a career spanning over two decades, Dr. Roig's scholarly journey began with groundbreaking research on human oogenesis during his Ph.D. at UAB, elucidating critical mechanisms of meiotic recombination. His postdoctoral tenure in the USA further enriched his expertise, revealing the intricate roles of DDR proteins in meiosis. Upon returning to UAB in 2010, Dr. Roig established his research group, delving into the regulation of meiotic prophase progression and its implications for fertility. His investigations have garnered significant funding and led to numerous publications in prestigious journals. Recognized for his contributions, Dr. Roig has received prestigious fellowships and awards, affirming his dedication to advancing scientific knowledge. Through mentorship and academic service, he continues to foster scientific excellence. Dr. Roig's unwavering commitment to inquiry and discovery underscores his readiness to propel research endeavors, contributing significantly to the understanding of reproductive biology.
Ongoing and recently completed projects that I would like to highlight include:
Program: Programa Estatal de I+D+i Orientada a los Retos de la Sociedad
Funding agency: Ministerio Ciencia e Innovación, Spain
Title: Estudio funcional de la espermatogénesis y la ovogénesis en mamíferos (PID2019-107082RB-I00).
Principal Investigator: Ignasi Roig
Budget: 217.800,00€
From 01/01/2020 to 31/12/2022
Program: European Proteomics Infrastructure Consortium grants
Funding agency: European Proteomics Infrastructure Consortium, Belgium
Title: Analysis of the transient interactome of TRIP13 in vivo (EPIC-XS-00306)
Principal Investigator: Ignasi Roig
Budget: 17.932,50€
From 01/04/2021 to 31/03/2022
Program: Projectes de recerca de la Fundació La Marató de TV3
Funding agency: Fundació La Marató de TV3, Spain
Title: Impact of COVID-19 on male reproductive health (677/U/2021)
Principal Investigator: Rafael Oliva (Network coordinator) - Ignasi Roig (PI group)
Budget: 399.821,25€
From 01/09/2021 to 31/08/2024
Program: Cost Actions
Funding agency: Cost Association, Belgium
Title: European Andrology Network– research coordination, education and public awareness (ANDRONET) (CA20119)
Principal Investigator: Rafael Oliva (Network coordinator) - Ignasi Roig (PI group)
Budget: 575.000,00€
From 27/109/2021 to 26/10/2025
Program: Grants to support the scientific activity of research groups in Catalonia
Funding agency: AGAUR, Spain
Title: Genome Integrity and Reproductive Biology (2021 SGR 00122)
Principal Investigator: Aurora Ruiz-Herrera (Network coordinator) - Ignasi Roig (PI group)
Budget: 60.000,00€
From 01/09/2023 to 31/12/2025
Program: Proyectos de Generación de Conocimiento
Funding agency: Ministerio Ciencia e Innovación, Spain
Title: Functional Analysis of mammalian gametogenesis (PID2022-138905OB-I00)
Principal Investigator: Ignasi Roig
Budget: 300,000.00€
From 01/09/2023 to 31/08/2026
Program: Wellcome Discovery Award
Funding agency: Wellcome Trust, UK
Title: The Healthy Reproductive Ageing (HERA) Study (302536/Z/23/Z)
Principal Investigator: Anna Murray (Lead Applicant) – Ignasi Roig (Collaborator)
Budget: 5,600,000.00£
From 01/04/2024 to 31/03/2030
B. Positions, Scientific Appointments and Honors
Positions and Scientific Appointments
2021-present Editor, Frontiers in Cell and Developmental Biology.
2018-present Member, European Society of Human Reproduction and Embryology (ESHRE).
2017-2022 Coordinator of the Master in Cytogenetics and Reproductive Biology, UAB.
2017-2022 Coordinator of the PhD program in Cell Biology, UAB.
2015-present Associate professor, Cell Biology, Physiology & Immunology Department, UAB, Spain.
2015-present Member, Institute of Catalan Studies (IEC), Spain.
2010-present Group Leader, Institut de Biotecnologia i Biomedicina, UAB, Spain.
2009-2015 Lecturer, Cell Biology, Physiology & Immunology Department, UAB, Spain.
Honors
2001-2005 Predoctoral fellowship, Programa de Formación de Profesorado Universitario, Ministerio de Educación y Cultura, Spain.
2001-2003 Travel fellowships, Programa de Formación de Profesorado Universitario, Ministerio de Educación y Cultura, Spain:
- Host: Dr. J. Smitz Lab, Free University of Brussels, Belgium, 2001.
- Host: Dr. H Scherthan Lab, Max Planck Institute for Molecular Genetics, Germany, 2002.
- Host: Dr. T. Ashley Lab, Yale University, USA, 2003.
2005 Extraordinary award for the best thesis of the Cell Biology Ph.D. Program, UAB
2008-2009 Invited professor, Cell Biology PhD program, UAB.
2009 Beatriu de Pinós Reincorporation Fellowship, Generalitat de Catalunya, Spain
(Awarded - Voluntarily declined due to incompatibility with professorship position).
2010 Short-term fellowship, European Molecular Biology Organization (EMBO), Germany
(Awarded - Voluntarily declined due to incompatibility with BE-DGR fellowship).
2010 Research visit fellowship BE-DGR, AGAUR-Generalitat de Catalunya.
2011 Ramon y Cajal Reincorporation Fellowship, Ministerio Ciencia e Innovación, Spain
(Awarded - Voluntarily declined due to incompatibility with professorship position).
2011 Aposta 2011 Award. UAB, Spain.
2013, 2014 Invited professor, Master in Cell Biology, Universidad Autónoma de Madrid, Spain.
2018 Research Fellowship, Fundación Dexeus Mujer, Spain.
2019 Member of the XII Premi Antoni Prevosti de Biologia Evolutiva selection committee, Societat Catalana de Biologia, Spain.
2019 Member of the “EMBO Outstanding Poster Prize Award” committee, EMBO meiosis meeting, La Rochelle, France.
2019 Member of the “Société Française de Génétique Poster Prize” committee, EMBO meiosis meeting, La Rochelle, France.
2020 Member of the “BioRender Annual Graphical Abstract Contest” committee.
2021 Full professor accreditation, AQU, Spain.
2021-present Full member of the Honor Society Sigma Xi, USA.
C. Contributions to Science
1. Roig I., Vanrell I., Ortega A., Cabero Ll., Egozcue E., Garcia M. The use of foetal ovarian stromal cell culture for cytogenetic diagnosis. Cytotechnology 2003 41:45-49.
2. Roig, I.*, Liebe, B.*, Egozcue, J., Cabero, Ll., Garcia, M. and Scherthan, H. Female-specific features of recombinational double-stranded DNA repair in relation to synapsis and telomere dynamics in human oocytes. Chromosoma 2004 113: 22-33. (* Co-first authors).
3. Roig I., Robles P., Garcia R., Egozcue J., Liebe B., Scherthan H, Garcia M. Chromosome 18 pairing behavior in human trisomic oocytes. Presence of an extra chromosome extends bouquet stage. Reproduction 2005 129: 565-575.
4. Roig I, Robles P., Garcia R., Martin M., Egozcue J., Cabero Ll., Barambio S., Garcia M. Evolution of the meiotic prophase and of the chromosome pairing process during human fetal ovarian development. Human Reproduction 2005 20:2463-9.
5. Roig I., Garcia R., Robles P., Cortvrindt R., Egozcue J., Smitz J., Garcia M. Human fetal ovarian culture permits meiotic progression and chromosome-pairing process. Human Reproduction. 2006 6:1359-67.
6. Robles P.*, Roig I.*, Garcia R., Ortega A., Egozcue J., Cabero Ll. and Garcia M. Pairing and Synapsis in oocytes from female fetuses with euploid and aneuploid chromosome complements. Reproduction 2007 133:899-907. (* Co-first authors).
7. Barchi M.*, Roig I.*, Di Giacommo M., de Roiij DG., Keeney S. and Jasin M. ATM promotes the obligate XY crossover and both crossover control and chromosome axis integrity on autosomes. PLoS Genet. 2008 May 23;4(5):e1000076. (* Co-first authors).
8. Roig I., Keeney S. Probing meiotic recombination decisions. Dev Cell. 2008 Sep;15(3):331-2.
9. Garcia-Cruz R., Roig I. and Garcia-Caldes M. Maternal origin of the human aneuploidies. Are homologue synapsis and recombination to blame? Notes (learned) from the underbelly. Genome Dyn. 2009; 5:128-36.
10. Garcia-Cruz R., Roig I., Robles P., Scherthan H. and Garcia Caldes M. ATR implication in DSB signaling and in the pachytene checkpoint in human oocytes. Reprod Biomed Online. 2009 Jan;18(1):37-44.
11. Robles P., Roig I., Garcia R., Brieño M., Martin M., Barbero J.L., Cabero Ll. and Garcia Caldes M. Analysis of the recombination process along chromosome 21 during human female pachytene stage. Reprod BioMed Online 2009 Jun;18(6):784-94.
12. Wojtasz L., Daniel K., Roig I., Bolcun-Filas E., Xu H., Boonsanay V., Eckmann C., Cooke H.J., Jasin M., Keeney S., McKay M.J. and Toth A. Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase. PLoS Genet. 2009 Oct;5(10):e1000702.
13. Garcia-Cruz R, Casanovas A, Brieño-Enríquez M, Robles P, Roig I, Pujol A, Cabero L, Durban M, Garcia Caldés M. Cytogenetic analyses of human oocytes provide new data on non-disjunction mechanisms and the origin of trisomy 16. Hum Reprod. 2010 Jan;25(1):179-91.
14. Brieño-Enríquez MA, Robles P, García-Cruz R, Roig I, Cabero L, Martínez F, Garcia Caldés M. A new culture technique that allows in vitro meiotic prophase development of fetal human oocytes. Hum Reprod. 2010 Jan;25(1):74-84.
15. Lu WJ, Chapo J, Roig I, Abrams JM. Meiotic recombination provokes functional activation of the p53 regulatory network. Science. 2010 Jun 4;328(5983):1278-81.
16. Garcia-Cruz R, Brieño MA, Roig I, Grossmann M, Velilla E, Pujol A, Cabero L, Pessarrodona A, Barbero JL, Caldés MG. Dynamics of cohesin proteins REC8, STAG3, SMC1 beta and SMC3 are consistent with a role in sister chromatid cohesion during meiosis in human oocytes. Hum Reprod. 2010 Sep;25(9):2316-27.
17. Roig I, Dowdle JA, Toth A, de Rooij DG, Jasin M, Keeney S. Mouse TRIP13/PCH2 is required for recombination and normal higher-order chromosome structure during meiosis. PLoS Genet. 2010 Aug 12;6(8). pii: e1001062.
18. Roig I, Brieño-Enríquez MA, Garcia Caldés M. Meiosis in a bottle: New approaches to overcome mammalian meiocyte study limitations. Genes. 2011, 2(1): 152-168.
19. Daniel K, Lange J, Hached K, Fu J, Anastassiadis K, Roig I, Steward AF, Wassmann K, Jasin M, Keeney S, Toth A. Meiotic homologue alignment and its quality check are controlled by mouse Hormad1. Nature Cell Biology 2011 May; 13(5):599-610.
20. Yin Y, Lin C, Tae Kim S, Roig I, Chen H, Liu L, Veith GM, Jin RU, Keeney S, Jasin M, Moley K, Zhou P, Ma L. The E3 ubiquitin ligase cullin 4A regulates meiotic progression in mouse spermatogenesis. Dev Biol. 2011 Aug 1; 356(1): 51-62.
21. Brieño-Enríquez MA, Robles P, Camats-Tarruella N, Garcia-Cruz R, Roig I, Cabero L, Martínez F, Garcia Caldés M. Human meiotic progression and recombination are affected by Bisphenol A exposure during in vitro human oocyte development. Human Reprod. 2011, Oct; 26(10): 2807-18.
22. Churchman ML, Roig I, Keeney S, Jasin M, Sherr CJ. Transient Arf expression in spermatogonia prevents p53-dependent elimination of spermatocytes during male germ cell development. PLoS Genet. 2011 Jul; 7(7): e1002157.
23. Brieño-Enríquez MA, Reig-Viader R, Cabero L, Toran N, Martínez F, Roig I, Garcia Caldés M. Gene expression is altered after Bisphenol A exposure in human fetal oocytes in vitro. Mol Hum Reprod. 2012 Apr; 18(4): 171-83.
24. Cole F, Kauppi L, Lange J, Roig I, Wang R, Keeney S, Jasin M. Homeostatic control of recombination is implemented progressively in mouse meiosis. Nature Cell Biology 2012 Mar 4. Doi: 10.1038/ncb2451
25. Stracker TH, Roig I, Knobel PA, Marjanović M.The ATM signaling network in development and disease. Front Genet. 2013 Mar 25;4:37. doi: 10.3389/fgene.2013.00037.
26. Robles P, Roig I, Garcia R, Brieño-Enríquez M, Martin M, Cabero L, Toran N, Garcia Caldés M. Presence of an extra chromosome alters meiotic double-stranded break repair dynamics and MLH1 foci distribution in human oocytes. Chromosoma. 2013 Mar;122(1-2):93-102. doi: 10.1007/s00412-012-0394-5. Epub 2013 Jan 4.
27. Muños-Fuentes V, Marcet-Ortega M, Alkorta-Aranburu G, Linde-Forsberg C, Morrell JM, Manzano-Piedras E, Söderberg A, Daniel K, Villalba A, Toth A, Di Rienzo A, Roig I, Vila C. Strong artificial selection in domestic mammals did not result in an increased recombination rate. Molecular Biology and Evolution. 2015 Feb; 32(2):510-23.
28. Pacheco S, Marcet-Ortega M, Lange J, Jasin M, Keeney S, Roig I. The ATM-signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes. PLoS Genet 2015 Mar 13; 11(3):e1005017.
29. Marjanović M, Sánchez-Huertas C, Terré B, Gómez R, Scheel JF, Pacheco S, Knobel PA, Martínez-Marchal A, Aivio S, Palenzuela L, Wolfrum U, McKinnon PJ, Suja JA, Roig I, Costanzo V, Lüders J, Stracker T. CEP63 deficiency promotes p53 dependent microcephaly and reveals a role for the centrosome in meiotic recombination. Nature Communications 2015 Jul 9;6:7676.
30. Marcet-Ortega M, Pacheco S, Martínez-Marchal A, Castillo H, Flores E, Jasin M, Keeney S, Roig I. p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes. PLoS Genet. 2017 Jun 15;13(6):e1006845.
31. Testa E, Nardozi D, Antinozzi C, Faieta M, Di Cecca S, Caggiano C, Fukuda T, Bonanno E, Zhenkun L, Maldonado-Linares A, Roig I, Di Giacomo M, Barchi M. H2AX and MDC1 protect genomic integrity in male germ cells by promoting recombination and activation of the recombination-dependent checkpoint. J Cell Sci. 2018 Mar 20;131(6). pii: jcs214411.
32. Pacheco S, Maldonado-Linares A, Marcet-Ortega M, Rojas C, Martinez-Marchal A, Fuentes-Lazaro J, Lange J, Jasin M, Keeney S, Fernandez-Capetillo O, Garcia-Caldes M, Roig I. ATR Is Required To Complete Meiotic Recombination In Mice. Nature Communications 2018; 9(1):2622.
33. Widger A, Mahadevaiah SK, Lange J, ElInati E, Zohren J, Hirota T, Pacheco S, Maldonado-Linares A, Stanzione M, Ojarikre O, Maciulyte V, de Rooij DG, Tóth A, Roig I, Keeney S, Turner JMA. ATR is a multifunctional regulator of male mouse meiosis. Nature Communications. 2018; 9(1):2622.
34. Abreu CA, Prakash R, Romanienko PJ, Roig I, Keeney S, Jasin M. Shu complex SWS1-SWSAP1 is required for mouse meiotic recombination in concert with the BRCA2 C terminus. Nature Communications 2018; 9(1):3961.
35. Pacheco S, Garcia-Caldés M, Roig I. ATR function is indispensable to allow proper mammalian follicle development. Chromosoma. 2019;128(3):489-500.
36. Gómez-H L, Felipe-Medina N, Condezo YB, Garcia-Valiente R, Ramos I, Roig I, Sanchez-Martín M, de Rooij D, Llano E, Pendás AM. Spermatoproteasome-deficient mice are proficient in meiotic DNA repair but defective in meiotic exit. PLoS Genet. 2019;15(8):e1008316.
37. Martínez-Marchal A, Huang Y, Guillot-Ferriols MT, Ferrer-Roda M, Guixé A, Garcia-Caldés M, Roig I. The DNA damage response is required for oocyte cyst breakdown and follicle formation in mice. PLoS Genet. 2020;16(11):e1009067.
38. Hoffmann ER, Roig I. Cas9 in Human Embryos: On Target but No Repair. Cell. 2020;183(6):1464-1466.
39. Ruth KS*, Day FR*, Hussain J*, Martínez-Marchal A*, Aiken CE, Azad A, Thompson DJ, Knoblochova L, Abe H, Tarry-Adkins JL, Gonzalez JM, Fontanillas P, Claringbould A, Bakker OB, Sulem P, Walters RG, Terao C, Turon S, Horikoshi M, Lin K, Onland-Moret NC, Sankar A, Hertz EPT, Timshel PN, Shukla V, Borup R, Olsen KW, Aguilera P, Ferrer-Roda M, Huang Y, Stankovic S, Timmers PRHJ, Ahearn TU, Alizadeh BZ, Naderi E, Andrulis IL, Arnold AM, Aronson KJ, […] Chen Z, Li L, Franke L, Burgess S, Deelen P, Pers TH, Grøndahl ML, Andersen CY, Pujol A, Lopez-Contreras AJ, Daniel JA, Stefansson K, Chang-Claude J, van der Schouw YT, Lunetta KL, Chasman DI, Easton DF, Visser JA, Ozanne SE, Namekawa SH, Solc P, Murabito JM, Ong KK, Hoffmann ER*, Murray A*, Roig I*, Perry JRB*. Genetic insights into biological mechanisms governing human ovarian ageing. Nature. 2021 Aug;596(7872):393-397. (*co-corresponding authors).
40. Sanchez-Donoso I, Ravagni S, Rodríguez-Teijeiro JD, Christmas MJ, Huang Y, Maldonado-Linares A, Puigcerver M, Jiménez-Blasco I, Andrade P, Gonçalves D, Friis G, Roig I, Webster MT, Leonard JA, Vilà C. Massive genome inversion drives coexistence of divergent morphs in common quails. Curr Biol 2022;32(2):462-469.e6.
41. Marcet-Ortega M, Maldonado-Linares A, López-Panadés M, Roig I. p53 Controls Meiotic Prophase Progression and Crossover Formation. Int J Mol Sci. 2022 Aug 29;23(17):9818.
42. Huang Y, Roig I. Genetic control of meiosis surveillance mechanisms in mammals. Front Cell Dev Biol. 2023 Feb 23;11:1127440.
43. Huang Y, Bucevic N, Coves C, Felipe-Medina N, Nikou N, Madrid-Sandín C, Ferrer Miralles N, Iborra A, Pendás AM, Roig I. Bend2 regulates the ovarian reserve in mice. Elife. Under Review.