GRAZIA GRAZIANI

Professore ordinario

email: graziani@uniroma2.it
telefono: 001839
edificio: F Sud
stanza: F38

CURRICULUM VITAE ET STUDIORUM
GRAZIA GRAZIANI

DATI PERSONALI

Stato civile: coniugata; tre figli
e-mail: graziani@uniroma2.it

TITOLI DI STUDIO
1982 Laurea in Medicina e Chirurgia Università degli Studi di Perugia (110/110 e lode), Perugia (sessione di febbraio dell’anno accademico 1980-1981, in data 27/2/1982)
1982 Abilitazione alla professione di Medico Chirurgo (sessione di aprile)
1986 Specializzazione in Oncologia, Università degli Studi di Roma “Tor Vergata” (70/70 e lode) (in data 10/10/1986)

ATTIVITÀ ACCADEMICA
1984-2001 Ricercatore Universitario, settore scientifico-disciplinare E07X (BIO/14) Farmacologia, Facoltà di Medicina e Chirurgia, Università di Roma “Tor Vergata” (in data 10/10/1984) (conferma in data 10/10/1987) presso il Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Facoltà di Medicina e Chirurgia fino al 1997; presso il Dipartimento di Neuroscienze dal 1998 al 2001.
2001-Gen. 2018 Professore Associato, settore scientifico-disciplinare BIO/14 Farmacologia Facoltà di Medicina e Chirurgia, Dipartimento di Neuroscienze – Dipartimento di Medicina dei Sistemi, Università di Roma “Tor Vergata” (conferma in data 1/11/2004).
2014 Abilitazione Scientifica Nazionale a Professore Ordinario settore scientifico-disciplinare BIO/14 Farmacologia
2015-Apr. 2019 Componente del Consiglio Universitario Nazionale (CUN)
2014-Ott. 2019 Membro aggiunto con funzioni consultive del Consiglio di Amministrazione dell’Università di Roma “Tor Vergata”
2018 Feb.-pres. Professore Ordinario, settore scientifico-disciplinare BIO/14 (BIOS-11/A) Farmacologia presso il Dipartimento di Medicina dei Sistemi, Università di Roma “Tor Vergata
2021-pres. Coordinatrice del Nucleo di Valutazione dell’Università di Roma “Tor Vergata”

ESPERIENZE FORMATIVE ALL’ESTERO

1982-83 Guest Scientist presso il laboratorio di Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.
1986 Guest Scientist come borsista dell’Associazione Italiana per la ricerca sul cancro (AIRC) presso il laboratorio di Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.
1987-90 Visiting Fellow come borsista Fogarty, presso il laboratorio di Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.

INDICI BIBLIOMETRICI

Coautore di 185 lavori scientifici pubblicati su riviste internazionali peer reviewed, in 113 dei quali è primo, ultimo autore o autore corresponding, di 11 capitoli di libri e di più di 120 abstract di partecipazione a congressi nazionali e internazionali. Impact Factor medio della produzione scientifica: 7

H-index di tutta la produzione scientifica: 46 [Scopus (Author ID: 35268329000)].


RESPONSABILITÀ SCIENTIFICA PER PROGETTI DI RICERCA

Progetti finanziati dal Ministero dell’Istruzione, dell’Università e della Ricerca

1997-98 Responsabile scientifico di Unità di Ricerca nell’ambito di un “Programma di ricerca scientifica di rilevante interesse nazionale” (PRIN) 1997 “Le infezioni dell’ospite immunodepresso: modulazione farmacologica delle risposte anti-micobatteriche T-dipendenti”
1999-2000 Responsabile scientifico di Unità di Ricerca nell’ambito di un PRIN 1999, “Risposte antitubercolari CD-1 ristrette: nuove strategie vaccinali”
2001-03 Responsabile Scientifico di Unità di Ricerca, Progetto di Ricerca “Fondi per gli Investimenti della Ricerca di Base” FIRB 2001, “Bilancio ospite-tumore nella terapia medica delle neoplasie: ruolo di NF-kB”
2004-05 Responsabile scientifico di Unità di Ricerca nell’ambito di un PRIN 2004, “Nuove strategie farmacologiche basate sull’inibizione della poli(ADP-ribosio) polimerasi per ridurre la chemioresistenza in vivo di tumori localizzati nel sistema nervoso centrale”
2007-08 Responsabile scientifico di Unità di Ricerca nell’ambito di un PRIN 2007, “Ruolo della poli (ADP-ribosil)azione nella neo-angiogenesi e crescita tumorale: potenziale terapeutico di inibitori della poli (ADP-ribosil)azione nella terapia antitumorale”
2022-pres. Spoke 3 Università degli Studi di Roma Tor Vergata, progetto MNESYS A multiscale integrated approach to the study of the nervous system in health and disease
2023-pres. Coordinatrice del progetto “Programma di ricerca scientifica di rilevante interesse nazionale” (PRIN) 2022, “Preclinical evaluation of the efficacy and cardiac safety of a novel humanized anti-VEGFR-1 monoclonal antibody targeting the tumor and the tumor microenvironment”

Progetti finanziati dal Ministero della Salute

2002-04 Responsabile Scientifico di Unità di Ricerca, Ricerca Finalizzata, Ministero della Salute, “Interazioni tra molecole di adesione e recettori di fattori di crescita vascolari: nuove strategie terapeutiche per il melanoma”
2024-pres. Responsabile Scientifico di Unità di Ricerca del Progetto PNRR dal titolo “Inhibition of VEGFR-1 with innovative biologics that target the tumor, tumorassociated vessels and immunosuppresive microenvironment for melanoma treatment” PNRR-MCNT2-2023-12377670

Progetti finanziati dall’Associazione Italiana per la Ricerca sul Cancro (AIRC)

2001-03 Responsabile di Progetto di Ricerca dell’Associazione Italiana per la ricerca sul cancro (AIRC) “New pharmacological strategies to overcome drug resistance in leukemias and brain tumors”
2013-16 Responsabile di Progetto di Ricerca dell’AIRC (AIRC 2013) “Targeting of VEGFR-1 and PARP-1 to reduce chemoresistance of glioblastoma and glioblastoma stem cells”
Nov 2017-2023 Responsabile di Progetto di Ricerca dell’AIRC (AIRC 2017) “Validation and humanization of a novel anti-VEGFR-1 monoclonal antibody for malignant melanoma treatment”
Nov 2024-pres. Responsabile di Progetto di Ricerca dell’AIRC (AIRC 2024) “Validation of an anti-VEGFR-1 humanized monoclonal antibody, scFv fragment and antibody-drug conjugate for glioblastoma”

Progetti finanziati dalla Regione Lazio

2010 Responsabile Scientifico di Unità di Ricerca nell’ambito del Progetto Filas 2010, “Tecnologie biomolecolari avanzate per l’identificazione di nuovi marcatori diagnostici, prognostici e predittivi della risposta terapeutica nelle malattie onco-ematologiche, infettive, allergiche, autoimmuni e di ambito cardiologico” €45,600
Apr. 2021-2023 Coordinatore progetto “Gruppi di ricerca 2020” - POR FESR Lazio 2014-2020 “Validazione di un nuovo anticorpo monoclonale multi-targeted per il trattamento di tumori e malattie retiniche”

Progetti finanziati dalla Compagnia di San Paolo

2002-04 Responsabile Scientifico di Unità di Ricerca, “Programma per la ricerca, la prevenzione e la cura in campo oncologico”, Compagnia di San Paolo, Progetto di Ricerca: “Ruolo dell’interazione VEGFR-1/integrine nei processi di angiogenesi, proliferazione e metastatizzazione tumorale: basi sperimentali per nuovi approcci terapeutici in campo oncologico”

Progetti finanziati dall’Istituto Superiore di Sanità

1995 Responsabile del contratto di ricerca “Immunofarmacologia di agenti antitubercolari, da soli o associati a potenziali fattori di interferenza HIV-dipendenti”, I progetto di ricerca Tubercolosi, Istituto Superiore di Sanità
1997 Responsabile del contratto di ricerca “Immunofarmacologia di agenti antitubercolari, da soli o associati a potenziali fattori di interferenza HIV-dipendenti” II progetto di ricerca Tubercolosi, Istituto Superiore di Sanità

Contributi liberali
2004-2005 Contributo liberale da parte della Guilford Pharmaceuticals per studi sull’attività antitumorale di nuovi inibitori della poli(ADP-ribosio) polimerasi (PARP).
2006 Conto terzi da parte della MGI Pharma per studi riguardanti la valutazione dell’attività antitumorale di nuovi inibitori della PARP in modelli animali di tumori cerebrali.
2007 Contributo liberale da parte della MGI Pharma per studi sull’attività contro glioblastoma e melanoma di nuovi inibitori della PARP.
2015-18 Contributo liberale da parte della Bio-Stilogit Pharmaceuticals per studi riguardanti la valutazione del potenziale anti-proliferativo e apoptotico di acido ellagico e derivati in modelli di carcinoma della vescica.
2021-2023 Contributo liberale Banca d'Italia per studi riguardanti la coniugazione con un composto citotossico di un nuovo anticorpo monoclonale umanizzato anti-VEGFR-1 che ha come bersaglio il tumore e il microambiente tumorale per il trattamento del melanoma

Progetti di ricerca di Ateneo, Università degli studi di Roma “Tor Vergata”

1991 Responsabile del contratto di ricerca quota 60%; “Azione mutagena e modificazioni antigeniche da farmaci”
1994 Responsabile del contratto di ricerca quota 60%; “Chemioresistenza ad alchilanti”
1995-96 Responsabile del contratto di ricerca quota 60%; “Apoptosi da agenti alchilanti”
1997-98 Responsabile del contratto di ricerca quota 60%, “Studio dell’attività telomerasica di tumori umani”
1999-2000 Responsabile del contratto di ricerca ex quota 60%, “Potenziamento della citotossicità da metilanti”
2001 Responsabile del contratto di ricerca ex quota 60%, “Nuovi bersagli per la terapia farmacologia dei tumori resistenti”
2002 Responsabile del contratto di ricerca ex quota 60%, “Influenza di inibitori di istone deacetilasi sulla crescita di cellule endometriali normali o tumorali”
2003 Responsabile del contratto di ricerca ex quota 60%, “Studio del ruolo di NF-kB nella risposta di cellule tumorali a chemioterapici.”
2005 Responsabile del contratto di Ricerca Scientifica di Ateneo, “Studio dell’influenza di peptidi che inibiscono l’interazione VEGFR-1/integrine nei processi di angiogenesi e nella chemiosensibilità di cellule endoteliali.”
2006 Responsabile del contratto di Ricerca Scientifica di Ateneo, “Valutazione del potenziale anti-angiogenico di molecole di nuova sintesi in modelli preclinici in vitro e in vivo”
2007 Responsabile del contratto di Ricerca Scientifica di Ateneo, “Ruolo della poli (ADP-ribosio) polimerasi-1 (PARP-1) nella neo-angiogenesi: potenziale terapeutico di inibitori della poli (ADP-ribosil)azione nella terapia antitumorale.”
2008 Responsabile del contratto di Ricerca Scientifica di Ateneo, “Studio dei meccanismi coinvolti nell’attività anti-angiogenica di inibitori della poli ADP-ribosilazione.”
2018 Responsabile Progetto Mission Sustainibility NextMel “New strategies for the treatment of resistant malignant melanoma: monoclonal antibodies targeting Platelet Derived Growth Factor-C/Neuropilin-1 interaction”

COLLABORAZIONE NELL’AMBITO DI PROGETTI DI RICERCA

1989-93 AIRC: “Alterazioni antigeniche indotte dai triazeno composti in cellule tumorali umane”
1995-97 AIRC: “Triazeno composti nella terapia delle leucemie acute. Ruolo e modulazione di meccanismi di riparo del DNA”
1996-98 Istituto Superiore di Sanità Italia-USA Terapia dei Tumori: “Cancer cell fate: Immortality or apoptosis? Role of DNA methylating agents”
1998-2000 AIRC “Poly(ADP-ribose) polymerase as a target to antagonize tumor cell resistance to methylating agents”
1998-2000 Istituto Superiore di Sanità, progetto AIDS, "Senescenza molecolare del sistema immunitario: possibile ruolo patogenetico nella suscettibilità ad agenti patogeni in corso di infezione da HIV"
2008-10 Participazione in qualità di co-applicant al progetto dal titolo “Potentiation of Chemotherapy of Neuroendocrine Carcinoid Tumors by PARP inhibitors”, Canadian Institutes of Health Research (CIHR).
2010-2012 Programma di formazione/informazione sui farmaci, sulle sostanze e pratiche mediche utilizzabili a fini di doping nelle attività sportive 2009, “Le conoscenze mediche e scientifiche sul doping: informare per prevenire” finanziato dal Ministero della Salute.
2023-pres. AIRC 2022 “Targeting PDGF-C/neuropilin-1 interaction: a strategy to hamper progression of melanoma resistant to BRAF/MEK inhibitors.”

DIREZIONE O PARTECIPAZIONE ALLE ATTIVITÀ DI UN GRUPPO DI RICERCA CARATTERIZZATO DA COLLABORAZIONI A LIVELLO INTERNAZIONALE

-Department of Molecular Biology, Medical Biochemistry and Pathology (BMBMP) Laval University, e Laboratory for Skin Cancer Research, Hospital Research Centre of Laval University 2705, Quebec, Canada (Prof. Girish Shah)
-Department of Biomedicine , University of Bergen, Norway (Prof. Hrvoje Miletic e Prof. Rolf Bjerkvig)
-Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, U.S.A. (Prof. Barry Gold)
- Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany (Prof. Zhao-Qi Wang)
- INSERM, UMR_S 938, Saint-Antoine Research Centre, Paris, France (Prof. Françoise Praz)

BREVETTI

2007 Graziani G, Vergati M. Immortalized endothelial cells. EP1828377
2017 Graziani G, Lacal PM; D’Atri S; Tentori L; Ruffini F; Failla C. Anticorpi anti-VEGFR-1 e usi di essi. IT 102016000034933; Anti-VEGFR-1 antibodies and their uses PCT/IB2017/000379

ATTIVITÀ EDITORIALE

Traduzione di capitoli di libri di Farmacologia:
-Xa edizione americana del libro Basic and Clinical Pharmacology di: Bertram G. Katzung (2006); capitoli 38, 39, 40, 43, 48 e 56, VIIa edizione italiana del libro “Farmacologia Generale e Clinica” (2008) a cura del Prof. Paolo Preziosi.

-XIa edizione americana del libro Basic and Clinical Pharmacology di: Bertram G. Katzung (2009); capitoli 37, 38, 39, 40, 43, 48 e 55; VIIIa edizione italiana del libro “Farmacologia Generale e Clinica” (2011) a cura del Prof. Paolo Preziosi.

-XIIa edizione americana del libro Basic and Clinical Pharmacology di: Bertram G. Katzung (2012); capitoli 37, 38, 39, 55; IXa edizione italiana del libro “Farmacologia Generale e Clinica” (2014) a cura del Prof. Paolo Preziosi.

-XIIIa edizione americana del libro Basic and Clinical Pharmacology di: Bertram G. Katzung (2014); capitoli 16 e 55, Xa edizione italiana del libro “Farmacologia Generale e Clinica” (2017) a cura del Prof. Paolo Preziosi.

-XIVa edizione americana del libro Basic and Clinical Pharmacology di: Bertram G. Katzung (2018); capitolo 55, Xa edizione italiana del libro “Farmacologia Generale e Clinica” (2021) a cura del Prof. Paolo Preziosi.

-XVa edizione americana del libro Basic and Clinical Pharmacology di: Bertram G. Katzung and T.W. Vanderah (2021); capitolo 55, XIa edizione italiana del libro “Farmacologia Generale e Clinica” (2023) a cura dei Prof. L. Brunetti, C. Mancuso e M. Taglialatela.

-VIIa edizione britannica del libro Rang & Dale’s Pharmacology di Humphrey P. Rang, M. Maureen Dale, James M. Ritter (2012); capitoli 49, 50, 51, 52, 53, 54 e 55 (Chemioterapia antimicrobica e antitumorale); VIIa edizione italiana del libro “Farmacologia” (2012) a cura dei Prof. Alfredo Gorio e Anna Maria Di Giulio.

-VIIIa edizione britannica del libro Rang & Dale’s Pharmacology di Humphrey P. Rang, M. Maureen Dale, James M. Ritter (2015); capitoli 50, 51, 52, 53, 54, 55 e 56 (Chemioterapia antimicrobica e antitumorale); VIIIa edizione italiana del libro “Farmacologia” (2016) a cura dei Prof. Alfredo Gorio e Anna Maria Di Giulio.

Partecipazione a comitati editoriali di riviste internazionali
2015-pres.: Associate Editor della rivista scientifica Chemotherapy, sezione Anticancer Agents (Karger).


Attività di revisore per riviste scientifiche internazionali:
Oncogene, International Journal of Cancer, Clinical Cancer Research, Pharmacological Research, British Journal of Cancer, European Journal of Cancer, British Journal of Pharmacology, Biochemical Pharmacology, American Journal of Pathology, The Faseb Journal, Future Medicinal Chemistry, Oncotarget.

ATTIVITÁ DI CONSULENZA PER INDUSTRIE FARMACEUTICHE

2011 Valutazione dell’anticorpo monoclonale anti-CTLA-4 ipilimumab (Yervoy) per il melanoma metastatico (Bristol-Myers Squibb).
2014 Valutazione dell’anticorpo monoclonale anti-PD-1 pembrolizumab (Keytruda) per il melanoma metastatico (Merck Sharp & Dohme).
2015 Valutazione dell’anticorpo monoclonale anti-PD-1 pembrolizumab (Keytruda) per il tumore del polmone in fase avanzata (Merck Sharp & Dohme).
2016 Valutazione dell’anticorpo monoclonale bispecifico emicizumab per l’emofilia di tipo A (Roche).
2016 Valutazione del farmaco inibitore di tirosin chinasi alectinib (Alecensa) per il tumore del polmone (Roche).
2016 Valutazione dell’anticorpo monoclonale anti-Her2 pertuzumab (Perjeta) come terapia adiuvante nel carcinoma mammario in fase precoce (Roche).
2016 Valutazione dell’anticorpo monoclonale anti-CD20 obinutuzumab (Gazyvaro) per il linfoma follicolare non trattato (Roche).
2017 Valutazione di un farmaco antagonista del recettore della vasopressina (V1a-R) per la terapia dell’autismo (Roche).
2017 Valutazione dell’inibitore di β-lattamasi nacubactam (Roche)
2017 Valutazione di un nuovo anticorpo monoclonale diretto verso l’emoagglutinina ad attività antivirale (Roche).
2017 Valutazione di anticorpi monoclonali contro la β-amiloide (gantenerumab e crenezumab) per la malattia di Alzheimer (Roche).
2019 La gestione del paziente affetto da ipertensione arteriosa polmonare nel contesto nazionale: diagnosi, presa in carico e rivalutazione dei pazienti (Janssen).
2022 Collaborazione per dossier bibliografico eparina sodica (non clinical overview; non clinical summaries, non clinical study report di) (Medic Italia srl).

PARTECIPAZIONE A COMITATO ETICO
2007-12: Componente in qualità di Farmacologa del Comitato Etico Ospedale Sant’Eugenio di Roma
2023 Lug.-pres. Componente in qualità di Farmacologa del Comitato Etico Territoriale Regione Lazio Area 4 con sede e Segreteria presso IRCCS Istituto Nazionale per le Malattie Infettive “Lazzaro Spallanzani” (INMI) comprendente le strutture sanitarie: IRCCS Istituto Nazionale per le Malattie Infettive “Lazzaro Spallanzani” (INMI); AO San Camillo-Forlanini; ASL RM 3 e ASL Viterbo.


APPARTENENZA A SOCIETÀ SCIENTIFICHE
1995-pres. Membro della Società Italiana di Farmacologia
2012-pres. Membro della Società Italiana di Chemioterapia


ATTIVITÀ DIDATTICA

Insegnamenti in Corsi di Laurea Magistrale a ciclo unico

1997-98 “Farmaci antitumorali, antimicrobici e antivirali”, corso di Laurea in Medicina e Chirurgia, presso la Facoltà di Medicina e Chirurgia “Campus Bio-Medico”, Roma
1998-99 “Farmacologia Speciale”, corso di Laurea in Medicina e Chirurgia, presso la Facoltà di Medicina e Chirurgia “Campus Bio-Medico”, Roma
1999-2000 “Farmaci antitumorali, antimicrobici e antivirali”, corso di Laurea in Medicina e Chirurgia, presso la Facoltà di Medicina e Chirurgia “Campus Bio-Medico”, Roma
1998-2000 “Farmaci antitumorali, antimicrobici e antivirali”, nell’ambito del corso integrato di “Farmacologia Generale e Chemioterapia”, corso di Laurea in Medicina e Chirurgia, presso la Facoltà di Medicina e Chirurgia, Università degli Studi di Roma “Tor Vergata”
2000-pres. “Farmaci antitumorali, antimicrobici e antivirali”, nell’ambito del corso integrato di “Farmacologia”, corso di Laurea in Medicina e Chirurgia, presso la Facoltà di Medicina e Chirurgia, Università degli Studi di Roma “Tor Vergata”
2006-2021 “Farmaci antimicrobici e antivirali”, nell’ambito del corso integrato di “Farmacologia”, corso di Laurea in Medicina e Chirurgia, presso la Facoltà di Medicina e Chirurgia, Università degli Studi Nostra Signora del Buon Consiglio, Tirana
2007-2021 “Farmacologia”, corso di Laurea in Odontoiatria, presso la Facoltà di Medicina e Chirurgia, Università degli Studi Nostra Signora del Buon Consiglio, Tirana
2009-15 “Pharmaceutical Biology”, Corso di Laurea in Pharmacy (in lingua inglese), Università degli Studi di Roma “Tor Vergata”
2011-pres. “Chemotherapy”, Corso di Laurea in Pharmacy (in lingua inglese), Università degli Studi di Roma “Tor Vergata”.
2015-pres. “Antitumor, amtimicrobial and antiviral agents”, nell’ambito del corso integrato di “Medicine and Surgery” (in lingua inglese), presso la Facoltà di Medicina e Chirurgia, Università degli Studi di Roma “Tor Vergata”

Insegnamenti in Corsi di Laurea Triennali

1992-98 “Oncologia”, Corso Universitario in Tecnico di Laboratorio Biomedico, Università di Roma “Tor Vergata”
1993-99 “Farmacologia”, Corso Universitario in Scienze Infermieristiche, Università di Roma “Tor Vergata”
1998-99 “Farmacologia”, Corso Universitario di Podologo, Università di Roma “Tor Vergata”
1996-2000 “Farmacologia”, Corso Universitario in Scienze Infermieristiche, Università di Roma “Tor Vergata”, sede di Sora (FR)
1993-pres. “Farmacologia”, Corso Universitario in Ortottisti-Assistenti in Oftalmologia, Università di Roma “Tor Vergata”
2003-06 “Oncologia”, Corso Universitario in Tecniche Diagnostiche Laboratorio Biomedico, Università di Roma “Tor Vergata”
2006-2024 “Farmacologia e Tossicologia”, Corso Universitario in Tecniche Diagnostiche Laboratorio Biomedico, Università di Roma “Tor Vergata”

Insegnamenti in Scuole di Specializzazione e Master

1990-94 “Farmacologia Cardiovascolare”, Scuola di Specializzazione in Cardiologia, Università di Roma “Tor Vergata”
1990-95 “Stadiazione dei tumori, fattori prognostici”, Scuola di Specializzazione in Oncologia, Università di Roma “Tor Vergata”
1992-95 “Chemioterapia antiblastica”, Scuola di Specializzazione in Ginecologia ed Ostetricia, Università di Roma “Tor Vergata”
1995-96 “Storia naturale dei principali tumori umani”, Scuola di Specializzazione in Oncologia, Università di Roma “Tor Vergata”
1991-2006 “Farmacologia”, Scuola di Specializzazione in Medicina Interna, Università di Roma “Tor Vergata”
1996-2006 “Biologia Molecolare”, Scuola di Specializzazione in Oncologia, Università di Roma “Tor Vergata”
2006-10 “Farmacogenomica in oncologia”, Scuola di Specializzazione in Oncologia, Università di Roma “Tor Vergata”
2014-2016 “Farmacologia”, Master di II livello in Aspetti Etici, Regolatori e Metodologici della Sperimentazione Clinica, Università di Roma “Tor Vergata”
2015-2016 “Farmacologia”, Master di I livello in Radiofarmaci: gestione, preparazione e assicurazione di qualità, Università di Roma “Tor Vergata”
2008-pres. Attività Caratterizzanti del Tronco Comune, Ambito Clinico, BIO/14 Farmacologia, Scuola di Specializzazione in Oncologia (nuovo ordinamento), Università di Roma “Tor Vergata”
2011-pres. “Farmacologia”, Scuola di Specializzazione in Oftalmologia, Università di Roma “Tor Vergata”
2022-pres. “Farmacologia”, Scuola di Specializzazione in Psichatria, Università di Roma “Tor Vergata”

Partecipazione a commissioni di esami, di laurea e dottorato

1990-pres. Membro delle commissioni degli esami di profitto dei corsi di Farmacologia nel corso di Laurea in Medicina e Chirurgia, Farmacia, Tecnico di Laboratorio Biomedico, Ortottisti Assistenti in Oftalmologia
Membro di commissioni di Laurea in Farmacia
Membro di commissioni di Dottorato di Ricerca

Attività tutoriali
Attività tutoriali per studenti, laureandi, dottorandi e specializzandi nella preparazioni di tesi.

ELENCO DELLE PUBBLICAZIONI

Lavori pubblicati in riviste internazionali peer reviewed
1. Riccardi C., Migliorati G., Giuliani-Bonmassar A., Graziani G. Adriamycin: Mechanisms of modulation of natural antitumor reactivity. Drugs under Experimental and Clinical Research 9: 365-368, l983.
2. Giuliani-Bonmassar A., Graziani G., Frati L., Bonmassar E. Interferon-induced changes of the susceptibility of murine and human lymphoma cells to natural cytotoxic lymphocytes. International Journal of Tissue Reaction 6: 35-4l, l984.
3. De Vecchis L., Graziani G., Macchi B., Grandori C., Pastore S., Popovic M., Gallo R. C., Bonmassar E. Decline of natural cytotoxicity of human lymphocytes following infection with human T cell leukemia/lymphoma virus (HTLV). Leukemia Research 9: 349-355, l985.
4. Graziani G., Pasqualetti D., Lopez E., D’Onofrio C., Testi A.M., Mandelli F., Gallo R.C., Bonmassar E. Increased susceptibility of peripheral mononuclear cells of leukemic patients to HTLV-I infection in vitro. Blood 69: ll75-ll8l, l987.
5. D’Onofrio C., Perno C.F., Mazzetti P., Graziani G., Caliò R., Bonmassar E. Depression of early phase of HTLV-I infection in vitro mediated by human Beta-interferon. British Journal of Cancer 57: 481-488, l988.
6. Fuggetta M.P., Graziani G., Aquino A., D’Atri S., Bonmassar E. Effect of hydrocortisone on human natural killer activity and its modulation by beta interferon. International Journal of Immunopharmacology 10: 687-694, 1988.
7. Graziani G., Ron D., Eva A., Srivastava S.K. The human dbl-proto-oncogene product is a cytoplasmic phosphorprotein which is associated with the cytoskeletal matrix. Oncogene 4: 823-829, 1989.
8. Ron D., Graziani G., Aaronson S.A., Eva A. The N-terminal region of proto-dbl down regulates its transforming activity. Oncogene 4: 1067-1072, 1989.
9. Eva A., Graziani G., Zannini M., Merin L.M., Khillan J.S., Overbeek P.A. Dominant dysplasia of the lens in transgenic mice expressing the dbl oncogene. The New Biologist 3: 158-168, 1991.
10. Graziani G., Ron D., Srivastava S., Eva A. Expression of the human dbl-oncogene and proto-oncogene products in insect cells using a baculovirus vector. Annali dell'Istituto superiore di sanità, 27(1), pp. 115–121, 1991.
11. Garcia de Herreros A., Dominguez I., Diaz-Meco M.T., Graziani G., M.E. Cornet, Guddal P.H, Johansen T., Moscat J. Requirement of phospholipase C-catalyzed hydrolysis of Xenopus laevis oocytes in response to insulin and ras p21. Journal of Biological Chemistry 266:6825-6829, 1991.
12. Ron D., Zannini M., Lewis M., Wichner R.B., Hunt L.T., Graziani G., Tronick S.R, Aaronson S.A., Eva. A. A region of proto-dbl essential for its transforming activity shows a sequence similarity to a yeast cell cycle gene, CDC 24, and the human breakpoint cluster gene, bcr. The new Biologist 3: 372-379, 1991.
13. Eisemann A., Ahn J.A., Graziani G., Tronick S.R., Ron D. Alternative splicing generates at least five different isoforms of the human basic-FGF receptor. Oncogene 6: 1195-1202, 1991.
14. Dominguez I., Marshall M.S., Gibbs J.B., De Herreros A.G., Cornet M.E., Graziani G., Diaz-Meco M.T., Johansen T., McCormick F., Moscat J. Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C. EMBO Journal 10: 3215-3220, 1991.
15. Graziani G., Nebreda A.R., Srivastava S., Santos E., Eva A. Induction of Xenopus oocyte meiotic maturation by the dbl oncogene product. Oncogene 7: 229-235, 1992.
16. D’Atri S., Alvino E., Tricarico M., Giuliani A, Isacchi G., Graziani G., Bonmassar E. Chemical xenogenization (CX) of cancer cells by triazene compounds: Studies with leukemia and melanoma cells. Chronica Dermatologica 2, 457-459, 1992.
17. Graziani G., Faraoni I., Zhang J., Caronti B., Lauro G., Bonmassar E., Macchi B. Transient HTLV-I infection of a human glioma cell line following cell-free exposure. Virology 197: 767-769, 1993.
18. Fuggetta M.P., Aquino A., Pepponi R., D’Atri S., Lanzilli G., Bonmassar E., Graziani G. In vitro combined effects of human interferons and interleukin-2 on natural cell-mediated cytotoxicity. International Journal of Immunopharmacology 15: 1-10, 1993.
19. Macchi B., Graziani G., Zhang J., Mastino A. Emergence of double-positive CD4/CD8 cells from adult peripheral blood mononuclear cells infected with Human T Cell Leukemia Virus Type I (HTLV-I). Cellular Immunology 149: 376-389, 1993.
20. Piccioni D., D’Atri S., Papa G., Caravita T., Franchi A., Bonmassar E., Graziani G. Cisplatin increases sensitivity of human leukemic blasts to triazene compounds. Journal of Chemotherapy 7: 224-228, 1995.
21. Tentori L., Graziani G., Gilberti S., Lacal P.M., Bonmassar E., D’Atri E. Triazene compounds induce apoptosis in O6-alkylguanine-DNA alkyltransferase deficient leukemia cell lines. Leukemia 9: 1888-1895, 1995.
22. Giuliani A., Vernole P., D’Atri S., Del Poeta G., D’Onofrio C., Faraoni I., Greiner J.W., Bonmassar E., Graziani G. In vitro infection of leukemic bone-marrow with HTLV-I generates immortalized cell lines expressing T or myeloid cell phenotype. Leukemia 9: 2071-2081, 1995.
23. Graziani G., Faraoni I., Grohmann U., Bianchi R., Binaglia L., Margison G. P., Watson A.J., Orlando L., Bonmassar E., D’Atri S. O6-alkylguanine-DNA alkyltransferase attenuates triazene-induced cytotoxicity and tumor cell immunogenicity in murine L1210 leukemia. Cancer Research 55: 6231-6236, 1995.
24. Reich-Slotky R., Shaoul E., Berman B., Graziani G., Ron D. Chimeric molecules between keratinocyte growth factor and basic fibroblast growth factor define domains that confer receptor binding specificities. Journal of Biological Chemistry 270: 29813-8, 1995.
25. Lacal P.M., D’Atri S., Orlando L., Bonmassar E., Graziani G. In vitro inactivation of human O6-alkylguanine-DNA alkyltransferase by antitumor triazene compounds. The Journal of Pharmacology and Experimental Therapeutics 279: 416-422, 1996.
26. Prete S.P., Aquino A., Masci G., Orlando L., Giuliani A., De Santis S., De Vecchis L., De Filippi R., Greiner J.W., Bonmassar E., Graziani G. Drug-induced changes of carcinoembryonic antigen expression in human cancer cells: effect of 5-fluoracil. The Journal of Pharmacology and Experimental Therapeutics 279: 1574-1581, 1996.
27. Faraoni I., Turriziani M., Bonmassar E., De Vecchis L., Graziani G. Development of a novel in vitro chemosensitivity assay: telomerase as a possible marker of tumor cell survival. Journal of Chemotherapy 8: 394-398, 1996.
28. Faraoni I., Turriziani M., Graziani G., De Vecchis L., Bonmassar E. Telomerase as a marker of tumor cell viability: a new approach for in vitro chemosensitivity assays. Journal of Experimental and Clinical Cancer Research 15: 311-312, 1996.
29. Faraoni I., Turriziani M., De Vecchis L., Laurenza M., Macchini V., Baliva G., Bonmassar E., Graziani G. In vitro chemosensitivity of neoplastic cells: Telomerase as a possible marker of tumor cell survival. Chronica Dermatologica 6, 6 SUPPL., 161-168, 1996
30. Giuliani A., Tentori L., Pepponi R., Porcelli S.A., Aquino A., Orlando L., Sugita M., Brenner M.B., Bonmassar E., Graziani G. Cytokine-induced expression of CD1b molecules by peripheral blood monocytes: influence of 3’-Azido-3’-deoxythymidine. Pharmacological Research 35: 135-140, 1997.
31. Tentori L., Orlando L., Lacal P.M., Benincasa E., Faraoni I;, Bonmassar E., D’Atri S., Graziani G. Inhibition of O6-alkylguanine-DNA alkyltransferase or poly(ADP-ribose) polymerase increases susceptibility of leukemic cells to apoptosis induced by temozolomide. Molecular Pharmacology 52: 249-258, 1997.
32. Tricarico M., Graziani G., Franzese O., Giuliani A., Starace G., Fuggetta M.P. CD1b expression in Molt-4 clones exposed to IL-4 and GM-CSF. European Journal of Histochemistry 41: 119-120, 1997.
33. Testorelli C., Bussini S., De Filippi R., Marelli O., Orlando L., Greiner J.W., Grohmann U., Tentori L., Giuliani A., Bonmassar E., Graziani G. Dacarbazine-induced immunogenicity of a murine leukemia is attenuated in cells transfected with mutated K-ras gene. Journal of Experimental and Clinical Cancer Research 16: 15-22, 1997.
34. Faraoni I., Turriziani M., Masci G., De Vecchis L., Shay J.S., Bonmassar E., Graziani G. Decline in telomerase activity as a measure of tumor cell killing by antineoplastic agents in vitro. Clinical Cancer Research 3: 579-585, 1997.
35. Tentori L., Graziani G., Porcelli S.A., Sugita M., Brenner M.B., Madaio R. Bonmassar E., Giuliani A., Aquino A. Rifampin increases cytokine-induced expression of CD1b molecule in human peripheral blood monocytes. Antimicrobial Agents and Chemotherapy 42: 550-554, 1998.
36. Tentori L., Lacal P.M., Benincasa E., Franco D., Faraoni I., Bonmassar E., Graziani G. Role of wild-type p53 on the antineoplastic activity of temozolomide alone or combined with an inhibitor of poly(ADP-ribose) polymerase. The Journal of Pharmacology and Experimental Therapeutics 285: 884-893, 1998.
37. D’Atri S., Tentori L., Lacal P.M., Graziani G., Pagani E., Benincasa E., Zambruno G, Bonmassar E., Jiricny J. (1998) Involvement of the mismatch repair system in temozolomide-induced apoptosis. Molecular Pharmacology 54: 334-341, 1998.
38. Giuliani A., Porcelli S.A., Tentori L., Graziani G., Testorelli C., Prete S.P., Brenner M.B., Bonmassar E., Bussini S., Cappelletti D., Aquino A. Effect of rifampin on CD1b molecule induction in peripheral blood monocytes and on mycobacteria recognition by double-negative T cells. Life Sciences 63: 985-994, 1998.
39. Bonmassar E., Aquino A., Giuliani A., Porcelli S.A., Tentori L., Testorelli C., Prete S.P., Brenner M.B., Cirello I., Cappelletti D., Graziani G. New aspects of immune responses against mycobacteria: immunopharmacology studies. Haematologica 83: 58-59, 1998.
40. Levati L., Marra G., Lettieri T., D’Atri S., Vernole P., Tentori L., Lacal P.M., Pagani E., Bonmassar E., Jiricny J., Graziani G. Mutation of the mismatch repair gene hMSH2 in a human T-cell leukemia line tolerant to methylating agents. Gene Chromosome & Cancer 23: 159-166, 1998.
41. Franzese O., Comandini A., Cannavò E., Graziani G., Bonmassar E. Effect of prostaglandin on proliferation and telomerase activity of human melanoma cells in vitro. Melanoma Research 8: 323-328, 1998.
42. Aquino A., Prete S.P., Giuliani A., Graziani G., Turriziani M., de Filippi R., Masci G., Greiner J.W., Bonmassar E., De Vecchis L. Effect of the combined treatment with 5-fluorouracil, -interferon or folinic acid in carcinoembryonic antigen expression in colon cancer cells. Clinical Cancer Research 4: 2473-2481, 1998.
43. Tonini G., Nunziata C., Prete S.P., Pepponi R., Turriziani M., Masci G., Graziani G., Bonmassar E., De Vecchis L. Adjuvant treatment of breast cancer: a pilot immunochemotherapy study with CMF, interleukin-2 and interferon-alpha. Cancer Immunology and Immunotherapy 47: 157-176, 1998.
44. Tricarico M., Macchi B., Morrone S., Bonmassar E., Fuggetta M.P., Graziani G. In vitro infection of CD4+ T lymphocytes with HTLV-I generates immortalized cell line coexpressing lymphoid and myeloid markers. Leukemia 13: 222-229, 1999.
45. Tentori L., Turriziani M., Franco D., Serafino A., Levati L., Roy R., Bonmassar E., Graziani G. Treatment with temozolomide and poly(ADP-ribose) polymerase inhibitors induces early apoptosis and increases base excision repair gene transcripts in leukemic cells resistant to triazene compounds. Leukemia 13: 901-909, 1999.
46. Faraoni I., Graziani G., Turriziani M., Masci G., Mezzetti M., Testori A., Veronesi U., Bonmassar E. Suppression of telomerase activity as an indicator of drug-induced cytotoxicity against cancer cells: in vitro studies with fresh human tumor samples. Laboratory Investigation 79: 993-1005, 1999.
47. Faraoni I., Graziani G. Telomerase as a potential anticancer target: growth inhibition and genomic instability. Drug Resistance Updates 3: 3-6, 2000.
48. Aquino A., Prete S.P., Baier S., Cappelletti D., Greiner J.W., De Vecchis L., Graziani G., Bonmassar E. Staurosporine increases carcinoembryonic antigen expression in a human colon cancer cell line. Journal of Chemotherapy 12: 167-172, 2000.
49. Faraoni I., Bonmassar E., Graziani G. Clinical applications of telomerase in cancer treatment. Drug Resistance Updates 3: 161-170, 2000.
50. D’Atri S., Graziani G., Lacal P.M., Nisticò V., Gilberti S., Faraoni I., Watson A.J., Bonmassar E., Margison G.P. Attenuation of O6-Methylguanine-DNA Methyltransferase Activity and mRNA levels by Cisplatin and Temozolomide in Jurkat Cells. The Journal of Pharmacology and Experimental Therapeutics 294: 664-671, 2000.
51. Tentori L., Vernole P., Lacal P.M., Madaio R., Portarena I., Levati L., Balduzzi A., Turriziani M., Dande P., Gold B., Bonmassar E., Graziani G. Cytotoxic and clastogenic effects of a DNA minor groove binding methyl sulfonate ester in mismatch repair deficient leukemia cells. Leukemia 14: 1451-1459, 2000.
52. Aquino A., Prete P.S., Guadagni F., Greiner J.W., Giuliani A., Orlando L., Masci G., De Santis S., Bonmassar E., Graziani G. Effect of 5-fluorouracil on carcinoembryonic antigen expression and shedding at clonal level in colon cancer cells. Anticancer Research 20: 3475--3484, 2000.
53. Prete S.P., Giuliani A., Iona E., Fattorini L., Orefici G., Franzese O, Bonmassar E., Graziani G. Bacillus calmette-guerin down-regulates CD1b induction by granulocyte-macrophage colony stimulating factor in human peripheral blood monocytes. Journal of Chemotherapy 13: 52-58, 2001.
54. Tentori L., Portarena I., Vernole P., De Fabritiis P., Madaio R., Balduzzi A., Roy R., Bonmassar E., Graziani G. Effects of single or split exposure of leukemic cells to temozolomide, combined with poly(ADP-ribose) polymerase inhibitors on cell growth, chromosomal aberrations and base excision repair components. Cancer Chemotherapy and Pharmacology 47: 361-369, 2001.
55. Tentori L., Portarena I., Bonmassar E., Graziani G. Combined effects of adenovirus-mediated wild-type p53 transduction, temozolomide and poly (ADP-ribose) polymerase inhibitor in mismatch repair deficient and non-proliferating tumor cells. Cell Death & Differentiation 8: 457-469, 2001.
56. Tentori L., Balduzzi A., Portarena I., Levati L., Vernole P., Gold B., Bonmassar E., Graziani G. Poly (ADP-ribose) polymerase inhibitor increases apoptosis and reduces necrosis induced by a DNA minor groove binding methyl sulfonate ester. Cell Death & Differentiation, 8: 817-828, 2001.
57. Pepponi R., Graziani G., Falcinelli S., Vernole P., Levati L., Lacal P.M., Pagani E., Bonmassar E., Jiricny J., D’Atri S. hMSH3 overexpression and cellular response to cytotoxic anticancer agents. Carcinogenesis 22: 1131-1137, 2001.
58. Giuliani A., Prete S.P., Graziani G., Aquino A., Balduzzi A., Sugita M., Brenner M.B., Iona E., Fattorini L., Orefici G., Porcelli S.A., Bonmassar E. Influence of Mycobacterium bovis bacillus Calmette Guerin on in vitro induction of CD1 molecules in human adherent mononuclear cells. Infection and Immunity 69: 7461-70, 2001.
59. Tentori L., Portarena I., Graziani G. Potential clinical applications of poly(ADP-ribose) polymerase (PARP) inhibitors. Pharmacological Research 45: 73-85, 2002.
60. Tentori L., Portarena I., Vernole P., Gold B., Graziani G. Apoptotic and genotoxic effects of a methyl sulfonate ester that selectively generates N3-methyladenine and poly (ADP-ribose) polymerase inhibitors in normal peripheral blood lymphocytes Cancer Chemotherapy and Pharmacology 49: 217-224, 2002.
61. Tentori L., Leonetti C., Scarsella M., d’Amati G., Portarena I., Zupi G., Bonmassar E., Graziani G. Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site. Blood 99: 2241-2244, 2002.
62. Graziani G., Tentori L., Portarena I., Barbarino M., Tringali G., Pozzoli G., Navarra P. Corticotropin-releasing hormone inhibits cell growth of human endometrial adenocarcinoma cells via CRH-R1 mediated activation of cAMP-protein kinase A pathway. Endocrinology 43: 807-13, 2002.
63. Dolci S., Levati L., Pellegrini M., Faraoni I., Graziani G., Di Carlo A., Geremia R. Stem cell factor activates telomerase in mouse mitotic spermatogonia and in primordial germ cells. Journal of Cell Science; 115: 1643-9, 2002.
64. Prete S.P., Cappelletti D., Baier S., Nasuti P., Guadagni F., De Vecchis L., Greiner J.W., Bonmassar E., Graziani G., Aquino A. Pharmacological modulation of carcinoembryonic antigen in human cancer cells: studies with staurosporine. International Immunopharmacology 2: 641-51, 2002.
65. Aquino A., Prete S.P., Balduzzi A., Formica V., Fossile Emanuela, Bonmassar L., Concolino F., Bonmassar E., Graziani G. Treatment of peripheral blood with staurosporine increases detection of circulating carcinoembryonic antigen positive tumor cells. International Journal of Cancer 100: 119-121, 2002.
66. Aquino A., Prete S.P., Balduzzi A., Fossile E., Formica V., Torino F., Bonmassar L., Di Giacomo A., Cappelletti D., Cardillo A., Graziani G. A novel method for monitoring response to chemotherapy based on the detection of circulating cancer cells: a case report. Journal of Chemotherapy 14: 412-416, 2002.
67. Tentori L., Portarena I., Torino F., Scerrati M., Navarra P., Graziani G. Poly(ADP-ribose) polymerase inhibitor increases growth inhibition and reduces G2/M cell accumulation induced by temozolomide in malignant glioma cells. Glia 40: 44-54, 2002.
68. Tentori L., Graziani G. Pharmacological strategies to increase the antitumor activity of methylating agents. Current Medicinal Chemitry 9: 1285-1301, 2002.
69. Tentori L., Leonetti C., Scarsella M., D’Amati G., Vergati M., Portarena I., Xu W., Kalish V., Zupi G., Zhang J., Graziani G. Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma. Clinical Cancer Research 9:5370-5379, 2003.
70. Graziani G., Tentori L., Portarena I., Vergati M., Navarra P. Valproic acid increases the stimulatory effect of estrogens on proliferation of human endometrial adenocarcinoma cells. Endocrinology 144: 2822-2828, 2003.
71. Tentori L., Portarena I., Barbarino M., Balduzzi A., Levati L., Vergati M., Biroccio A., Gold B., Lombardi M.L., Graziani G. Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (ADP-ribose) polymerase inhibitor. Molecular Pharmacology 63: 192-202, 2003.
72. Vairano M., Graziani G., Tentori L., Trincali G., Navarra P., Dello Russo C. Primary cultures of microglial cells for testing toxicity of anticancer drugs. Toxicology Letters 148: 91-94, 2004.
73. Tentori L., Graziani G. Correspondence re: DC Lev et al., Dacarbazine causes transcriptional up-regulation of interleukin 8 and vascular endothelial growth factor in melanoma cells: a possible escape mechanism from chemotherapy. Mol Cancer Ther, 2003;2(8):753-63. Molecular Cancer Therapeutics 2004;3:383; author reply 383-4.
74. Tentori L., Graziani G. Temozolomide: an update on pharmacological strategies to increase its antitumor activity. Medicinal Chemistry Reviews-Online 1:144-150,2004.
75. Tentori L., Leonetti C., Scarsella M., Vergati M., Xu W., Calvin D., Morgan L,. Tang Z., Woznizk K., Alemu C., Hoover R., Lapidus R., Zhang J., Graziani G. Brain distribution and efficacy as chemosensitizer of an oral formulation of PARP-1 inhibitor GPI 15427 in experimental models of CNS tumors. International Journal of Oncology 26:415-422, 2005.
76. Tentori L., Forini O., Fossile E., Muzi A., Vergati M., Portarena I., Amici C., Gold B., Graziani G. N3-methyladenine induces early poly (ADP-ribosylation), reduction of NF-kB DNA binding ability and nuclear up-regulation of telomerase activity. Molecular Pharmacology 67:572-81, 2005.
77. Tentori L., Vergati M., Muzi A., Levati L., Ruffini F., Forini O., P. Vernole P., Lacal P.M., Graziani G. Generation of an immortalized human endothelial cell line as a model of neovascular proliferating endothelial cells to assess chemosensitivity to anticancer drugs. International Journal of Oncology 27:525-435, 2005.
78. Graziani G., Battaini F., Zhang J. PARP-1 inhibition to treat cancer, ischemia, inflammation. Pharmacological Research 52:1-4, 2005.
79. Tentori L., Graziani G. Chemopotentiation by PARP inhibitors in cancer therapy. Pharmacological Research52:25-33, 2005.
80. Graziani G., Szabò C. Clinical perspectives of PARP inhibitors Pharmacological Research 52:109-118, 2005.
81. Tentori L., Leonetti C., Scarsella M., Muzi A., Vergati M., Forini O., Lacal P.M., Ruffini F., Gold B., Lie W., Zhang J., Graziani G. Poly (ADP-ribose) glycohydrolase inhibitor as chemosensitizer of malignant melanoma for temozolomide. European Journal of Cancer 41: 2948-2957, 2005.
82. Vernole P., Tedeschi B., Tentori L., Levati L., Argentin G., Cicchetti R., Forini O., Graziani G., D’Atri S. Role of the mismatch repair system and p53 in the clastogenicity and cytotoxicity induced by bleomycin. Mutation Research/ Fundamental and Molecular Mechanisms of Mutagenesis 594:63-77, 2006.
83. Graziani G., Ferrandina G., Pozzoli G., Vergati M., Muzi A., Legge F., Tentori L., Scambia G., Navarra P. Corticotrophin-releasing hormone receptor-1 in human endometrial cancer. Oncology Reports 15:375-379, 2006.
84. Tentori L., Leonetti C., Scarsella M., Muzi A., Mazzon E., Vergati M., Forini O., Lapidus R., Xu W., Dorio A.S., Zhang J., Cuzzocrea S., Graziani G. Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma. The Faseb Journal 20:1709-1711; full-lenght article online E1024-36, 2006.
85. Graziani G., Tentori L., Muzi A., Vergati M., Tringali G., Pozzoli G., Navarra P. Evidence that corticotropin-releasing hormone inhibits cell growth of human breast cancer cells via the activation of CRH-R1 receptor subtype. Molecular and Cellular Endocrinology 264:44-49, 2007.
86. Prete S.P., Giuliani A., D’Atri S., Graziani G., Balduzzi A., Oggioni M.R., Iona E., Girolomoni G., Bonmassar L., Romani L., Franzese O. BCG-infected adherent mononuclear cells release cytokines that regulate group 1 CD1 molecule expression. International Immunopharmacology 7:321-332, 2007.
87. Tentori L., Graziani G. Doping with growth hormone/IGF-1, anabolic steroids or erythropoietin: is there a cancer risk? Pharmacological Research 55:359-369, 2007.
88. Tentori L., Lacal P.M., Muzi A., Dorio A.S., Leonetti C., Scarsella M., Ruffini F., Xu W., Mine W., Stoppacciaro A., Colarossi C., Wang Z.-Q., Zhang J., Graziani G. Poly(ADP-ribose) polymerase (PARP) inhibition or PARP-1 gene deletion reduces angiogenesis. European Journal of Cancer 43:2124-2133, 2007.
89. Iacopino F., Urbano R., Graziani G., Muzi A., Navarra P., Sica G. Valproic acid activity in androgen-sensitive and -insensitive human prostate cancer cells. International Journal of Oncology 32:1293-1303, 2008.
90. Tentori L., Muzi A., Dorio A.S., Bultrini S., Mazzon E., Lacal P.M., Shah G.M., Zhang J., Navarra P., Nocentini G., Cuzzocrea S., Graziani G. Stable depletion of poly (ADP-ribose) polymerase-1 reduces in vivo melanoma growth and increases chemosensitivity. European Journal of Cancer 44:1302-1314, 2008.
91. Tentori L., Dorio A.S., Muzi A., Lacal P.M., Ruffini F., Navarra P., Graziani G. The integrin antagonist cilengitide increases the antitumor activity of temozolomide against malignant melanoma. Oncology Reports 19:1039-1043, 2008.
92. Lacal P.M., Morea V., Ruffini F., Orecchia A., Failla C.M., Dorio A.S., Soro S., Tentori L., Zambruno G., Graziani G., Tramontano A., D’Atri S. Inhibition of endothelial cell migration and angiogenesis by a vascular endothelial growth factor receptor-1 derived peptide. European Journal of Cancer 44:1914-1921, 2008.
93. Tentori L., Graziani G. Recent approaches to improve the antitumor efficacy of temozolomide. Current Medicinal Chemitry 16:245-257, 2009.
94. Lacal P.M, Tentori L., Muzi A., Ruffini F., Dorio A.S., Xu W., Arcelli D., Zhang J., Graziani G. Pharmacological inhibition of poly(ADP-ribose) polymerase activity down-regulates the expression of syndecan-4 and Id-1 in endothelial cells. International Journal of Oncology 34:861-872, 2009.
95. Vernole P., Muzi A., Volpi A., Dorio A.S., Terrinoni A., Shah G.M., Graziani G. Inhibition of homologous recombination by treatment with BVDU (brivudin) or by RAD51 silencing increases chromosomal damage induced by bleomycin in mismatch repair-deficient tumour cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 664:39-47, 2009.
96. Fiorani P., Tesauro C, Mancini G, Chillemi G, D’Annessa I, Graziani G, Tentori L, Muzi A. and Desideri A. Evidence of the crucial role of the linker domain on the catalytic activity of human topoisomerase I by experimental and simulative characterization of the Lys681Ala mutant. Nucleic Acids Research 37:6849-6858, 2009.
97. Tentori L., Muzi A., Dorio A.S., Scarsella M., Leonetti C., Shah G.M., Xu W., Camaioni E., Gold B., Pellicciari R., Dantzer F., Zhang J., Graziani G. Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent. Current Cancer Drug Targets 10:368-383, 2010.
98. Salvati E., Scarsella M., Porru M., Rizzo A., Iachettini S., Tentori L., Graziani G., D’Incalci M., Stevens M.F., Orlandi A., Passeri D., Gilson E., Zupi G., Leonetti C., Biroccio A. PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy. Oncogene 29:6280-6293, 2010.
99. Bonmassar L. , Fossile E., Scoppola A., Graziani G., Prete S.P., Formica V., Cappelletti D., De Vecchis L., Cardillo A., Concolino F., D’Atri S., Balduzzi A., Torino F., Caporaso P., Greiner J.W., Bonmassar E., Roselli M., Aquino A. Detection of circulating tumor cells is improved by drug-induced antigen up-regulation: preclinical and clinical studies. Anticancer Research 30:4721-4730, 2010.
100. D’Onofrio G., Tramontano F., Dorio A.S., Muzi A., Maselli V., Fulgione D., Graziani G., Malanga M., Quesada P. Poly(ADP-ribose) polymerase signaling of topoisomerase 1-dependent DNA damage in carcinoma cells. Biochemical Pharmacology 81:194-202, 2011.
101. Levati L., Ruffini F., Muzi A., Umezawa K., Graziani G., D’Atri S., Lacal P.M. The Placenta Growth Factor induces melanoma resistance to temozolomide through a mechanism that involves the activation of the transcription factor NF-κB International Journal of Oncology 38:241-247, 2011.
102. Tentori L., Dorio A.S., Mazzon E., Muzi A., Sau A., Cuzzocrea S., Vernole P., Federici G., Caccuri A.M., Graziani G. The glutathione transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) increases temozolomide efficacy against malignant melanoma. European Journal of Cancer 47:1219-1230, 2011.
103. Ruffini F., Failla C.M., Orecchia A., Bani M.R., Dorio A.S., Fortes C., Zambruno G., Graziani G., Giavazzi R., D’Atri S., Lacal. P.M. Expression of the soluble vascular endothelial growth factor receptor-1 in cutaneous melanoma: role in tumour progression. British Journal of Dermatology 164:1061-1070, 2011.
104. Aquino A., Graziani G., Franzese O., Prete S.P., Bonmassar E., Bonmassar L., D’Atri S. Exogenous control of the expression of group i CD1 molecules competent for presentation of microbial nonpeptide antigens to human T lymphocytes. Clinical and Developmental Immunology 2011:790460, 2011.
105. Vernole P., Muzi A., Volpi A., Terrinoni A., Dorio A.S., Tentori L., Shah G.M., Graziani G. Common fragile sites in colon cancer cell lines: Role of mismatch repair, RAD51 and poly(ADP ribose) polymerase-1. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 712:40-48, 2011.
106. Graziani G., Tentori L., Navarra P. Ipilimumab: A novel immunostimulatory monoclonal antibody for the treatment of cancer. Pharmacological Research 65:9-22, 2012.
107. Leonetti C., Biroccio A., Graziani G., Tentori L. Targeted Therapy for Brain Tumours: Role of PARP Inhibitors. Current Cancer Drug Targets 12:218-36, 2012.
108. Cavallo F., Graziani G., Antinozzi C., Feldman D.R., Houldsworth J., Bos G.J., Chaganti R.S.K., Moynahan M.E., Jasin M., Barchi M. Reduced proficiency in homologous recombination underlies the high sensitivity of Embryonal Carcinoma Testicular Germ Cell Tumors to cisplatin and poly (ADP-ribose) polymerase inhibition. Plos ONE 7:e51563, 2012.
109. Caporali S., Levati L., Graziani G., Muzi A., Atzori M.G., Bonmassar E., Palmieri G., Ascierto P.A., D’Atri S. NF-kappaB is activated in response to temozolomide in an AKT-dependent manner and confers protection against the growth suppressive effect of the drug. Journal of Translational Medicine 10:252, 2012.
110. Tentori L., Leonetti C., Muzi A., Dorio A.S., Porru M., Dolci S., Campolo F., Vernole P., Lacal P.M., Praz F., Graziani G. Influence of MLH1 on colon cancer sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitor combined with irinotecan. International Journal of Oncology 43:210-218, 2013.
111. Tentori L., Muzi A., Dorio A.S., Dolci S., Campolo F., Vernole P., Lacal P.M., Praz F., Graziani G. MSH3 expression does not influence the sensitivity of colon cancer HCT116 cells to oxaliplatin and poly(ADP-ribose) polymerase (PARP) inhibitor as monotherapy or in combination. Cancer Chemotherapy and Pharmacology 72:117-125, 2013.
112. Ruffini F., Tentori L., Dorio A.S., Arcelli D., d’Amati G., Graziani G., D’Atri S., Lacal P.M. Platelet derived growth factor C and calpain-3 are modulators of human melanoma cell invasive capability. Oncology Reports 30:2887-96, 2013.
113. Martire S., Fuso A., Rotili D., Tempera I., Giordano C., De Zottis I., Muzi A., Vernole P., Graziani G., Lococo E., Faraldi M. , Maras B., Scarpa S., Mosca L., d’Erme M. PARP-1 modulates Amyloid Beta peptide-induced neuronal damage. Plos ONE 8:e72169, 2013.
114. Lacal P.M., Petrillo M.G., Ruffini F., Muzi A., Bianchini R., Ronchetti S., Migliorati G., Riccardi C., Graziani G.*, Nocentini G*. Glucocorticoid-induced tumor necrosis factor receptor family-related ligand triggering upregulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 and promotes leukocyte adhesion. The Journal of Pharmacology and Experimental Therapeutics 347:164-172, 2013. *equally contributing authors
115. Shah G.M., Robu M., Purohit N.K., Rajawat J., Tentori L., Graziani G. PARP Inhibitors in Cancer Therapy: Magic Bullets but Moving Targets. Frontiers in Oncology 3:279, 2013.
116. Tentori L., Lacal P.M., Graziani G. Challenging resistance mechanisms to therapies for metastatic melanoma. Trends in Pharmacological Sciences 34:656-666, 2013.
117. Tentori L., Ricci-Vitiani L., Muzi A., Ciccarone F., Pelacchi F., Calabrese R., Runci D., Pallini R., Caiafa P., Graziani G. Pharmacological inhibition of poly(ADP-ribose) polymerase-1 modulates resistance of human glioblastoma stem cells to temozolomide. BMC Cancer 14:151, 2014.
118. Tesauro C.*, Graziani G.*, Arnò B., Zuccaro L., Muzi A., D’Annessa I., Santori E., Tentori L., Leonetti C., Fiorani P., Desideri A. Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers. Journal of Experimental & Clinical Cancer Research 33:71, 2014. *equally contributing authors
119. Ruffini F., Graziani G., Levati L, Tentori L, D’Atri S, Lacal PM. Cilengitide down-modulates invasiveness and vasculogenic mimicry of neuropilin-1 expressing melanoma cells through the inhibition of αvβ5 integrin. International Journal of Cancer 136:E545-58, 2015.
120. Faraoni I., Compagnone M., Lavorgna S., Angelini D.F., Cencioni M.T., Piras E., Panetta P., Ottone T., Dolci S., Venditti A., Graziani G.*, Lo-Coco F.* BRCA1, PARP1 and γH2AX in Acute Myeloid Leukemia: Role as Biomarkers of Response to the PARP Inhibitor Olaparib. Biochimica et Biophysica Acta – Molecular Basis of Disease 1852:462-72, 2015. *equally contributing authors
121. Graziani G., Artuso S., De Luca A., Muzi A., Rotili D., Scimeca M., Atzori M.G., Ceci C., Mai A., Leonetti C., Levati L., Bonanno E., TentoriL., Caccuri A.M. A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib. Biochemical Pharmacology 95:16-27, 2015.
122. Graziani G., Lacal P.M. Neuropilin-1 as Therapeutic Target for Malignant Melanoma. Frontiers in Oncology 5:125, 2015.
123. Minotti G, Graziani G, Delogu G. Editorial. Chemotherapy 61:1-2, 2016.
124. Pagani E., Ruffini F., Antonini Cappellini G., Scoppola A., Fortes C., Marchetti P., Graziani G., D’Atri S., Lacal P.M. Placenta growth factor and neuropilin-1 collaborate in promoting melanoma aggressiveness. Internation Journal of Oncology 48:1581-9, 2016.
125. Eskilsson E., Rosland G.V., Talasila K.M., Knappskog S., Keunen O., Sottoriva A., Foerster S., Solecki G., Taxt T., Jirik R., Fritah S., Harter P.N., Välk K., Al Hossain J., Joseph J.V., Jahedi R., Saed H.S., Piccirillo S.G., Spiteri I., Euskirchen P., Graziani G., Daubon T., Lund-Johansen M., Enger P.Ø., Winkler F., Ritter C.A., Niclou S.P., Watts C., Bjerkvig R., Miletic H. EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation. Neuro Oncology 18: 1644-55, 2016.
126. Graziani G., Ruffini F., Tentori L., Scimeca M., Dorio A.S., Atzori M.G., Failla C.M., Morea M., Bonanno E., D’Atri S., Lacal P.M. Antitumor activity of a novel anti-vascular endothelial growth factor receptor-1 monoclonal antibody that does not interfere with ligand binding. Oncotarget 7:72868-72885, 2016.
127. Ceci C, Tentori L, Atzori MG, Lacal PM, Bonanno E, Scimeca M, Cicconi R, Mattei M, de Martino MG, Vespasiani G, Miano R, Graziani G. Ellagic Acid Inhibits Bladder Cancer Invasiveness and In Vivo Tumor Growth. Nutrients 8, pii: E744, 2016.
128. Dello Russo C., Lisi L., Tentori L., Navarra P., Graziani G., Combs C.K. Exploiting Microglial Functions for the Treatment of Glioblastoma. Current Cancer Drug Targets 17:267-281, 2017.
129. Cesarini V., Martini M., Ricci Vitiani L., Gravina G.L., Di Agostino S., Graziani G., D’Alessandris Q.G., Pallini R., Larocca L.M., Rossi P., Jannini E.A., Dolci S. Type 5 phosphodiesterase regulates glioblastoma multiforme aggressiveness and clinical outcome. Oncotarget 8:13223-13239, 2017.
130. Noguera N.I., Pelosi E., Angelini D.F., Piredda M.L., Guerrera G., Piras E., Battistini L., Massai L., Berardi A., Catalano G., Cicconi L., Castelli G., D’Angiò A., Pasquini L., Graziani G., Fioritoni G., Voso M.T., Mastrangelo D., Testa U., Lo-Coco F. High-dose ascorbate and arsenic trioxide selectively kill acute myeloid leukemia and acute promyelocytic leukemia blasts in vitro. Oncotarget 8:32550-32565, 2017.
131. Salvati E., Botta L., Amato J., Di Leva F., Zizza P., Gioiello A., Pagano B., Graziani G., Tarsounas M., Randazzo A., Novellino E., Biroccio A., Cosconati S. Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment. Journal of Medicinal Chemistry 60:3626-3635, 2017.
132. De Domenico E., D’Arcangelo G., Faraoni I., Palmieri M., Tancredi V., Graziani G., Grimaldi P., Tentori L. Modulation of GDF11 expression and synaptic plasticity by age and training. Oncotarget 8:57991-58002, 2017.
133. Atzori MG, Tentori L, Ruffini F, Ceci C, Lisi L, Bonanno E, Scimeca M, Eskilsson E, Daubon T, Miletic H, Ricci Vitiani L, Pallini R, Navarra P, Bjerkvig R, D'Atri S, Lacal PM, Graziani G. The anti-vascular endothelial growth factor receptor-1 monoclonal antibody D16F7 inhibits invasiveness of human glioblastoma and glioblastoma stem cells. Journal of Experimental and Clinical Cancer Research 36:106, 2017.
134. Lisi L., Graziani G., Navarra P. Macrophages/microglia in glioblastoma: a Zelig-like story of changing phenotypes. Translational Cancer Research 6 (Suppl 6):S1101-S1103, 2017.
135. Ruffini F., Levati L., Graziani G., Caporali S., Atzori M.G., D’Atri S., Lacal P.M. Platelet-derived growth factor-C promotes human melanoma aggressiveness through activation of neuropilin-1. Oncotarget 8:66833-66848, 2017.
136. Eskilsson E., Gro V.R., Solecki G., Wang Q., Harter P.N., Graziani G., Verhaak R.G.W.,, Winkler F., Bjerkvig R., Miletic H. EGFR heterogeneity and implications for therapeutic intervention in glioblastoma. Neuro-Oncology 20:743-752, 2018.
137. Atzori MG, Tentori L, Ruffini F, Ceci C, Bonanno E, Scimeca M, Lacal P.M., Graziani G. The anti-vascular endothelial growth factor receptor-1 monoclonal antibody D16F7 inhibits glioma growth and angiogenesis in vivo. Journal of Pharmacology and Experimental Therapeutics 364:77-86, 2018.
138. Lacal PM, Atzori MG, Ruffini F, Tentori L, Graziani G. Poly(ADP‑ribose) polymerase inhibitor olaparib hampers placental growth factor‑driven activation of myelomonocytic cells. Oncology Reports 39:2261-2269, 2018.
139. Franzese O, Barbaccia ML, Bonmassar E, Graziani G. Detrimental and beneficial effects of antiretroviral therapy on HIV-associated immunosenescence. Chemotherapy 63:64-75, 2018.
140. Franzese O, Battaini F, Graziani G., Tentori L, Barbaccia ML, Aquino A, Roselli M, Fuggetta MP, Bonmassar E, Torino F. Drug-induced xenogenization of tumors: A possible role in the immune control of malignant cell growth in the brain? Pharmacological Research 131:1-6, 2018.
141. Faraoni I, Aloisio F, De Gabrieli A, Irno Consalvo M, Lavorgna S, Voso MT, Lo-Coco F, Graziani G. The poly(ADP-ribose) polymerase inhibitor olaparib induces up-regulation of death receptors in primary acute myeloid leukemia blasts by NF-κB activation. Cancer Letters 423:127-138, 2018.
142. Lacal PM, Graziani G. Therapeutic implication of vascular endothelial growth factor receptor-1 (VEGFR-1) targeting in cancer cells and tumor microenvironment by competitive and non-competitive inhibitors. Pharmacological Research 13:97-107, 2018.
143. Ceci C, Lacal PM, Tentori L, De Martino MG, Miano R, Graziani G. Experimental Evidence of the Antitumor, Antimetastatic and Antiangiogenic Activity of Ellagic Acid. Nutrients 10(11). pii: E1756, 2018.
144. Faraoni I and Graziani G. Role of BRCA Mutations in Cancer Treatment with Poly(ADP-ribose) Polymerase (PARP) Inhibitors. Cancers 10,487, 2018.
145. Faraoni I, Giansanti M, Voso MT, Lo-Coco F, Graziani G. Targeting ADP-ribosylation by PARP inhibitors in acute myeloid leukaemia and related disorders. Biochemical Pharmacology 167:133-148, 2019.
146. Tundo GR*, Sbardella D, Lacal PM, Graziani G.*, Marini S. On the Horizon: Targeting Next-Generation Immune Checkpoints for Cancer Treatment. Chemotherapy 64:62-80, 2019. *Co-corresponding author
147. Faraoni I, Consalvo MI, Aloisio F, Fabiani E, Giansanti M, Di Cristino F, Falconi G, Tentori L, Di Veroli A, Curzi P, Maurillo L, Niscola P, Lo-Coco F, Graziani G.*, Voso MT* Cytotoxicity and Differentiating Effect of the Poly(ADP-Ribose) Polymerase Inhibitor Olaparib in Myelodysplastic Syndromes*equally contributing authors Cancers 11: E1373, 2019.
148. Sciarretta F, Fulci C, Palumbo C, Rotili D, Tentori L, Graziani G, Caccuri AM. Effects of glutathione transferase-targeting nitrobenzoxadiazole compounds in relation to PD-L1 status in human melanoma cells. Chemotherapy 64, 138-145, 2019.
149. Atzori MG, Ceci C, Ruffini F, Trapani M, Barbaccia ML, Tentori L, D’Atri S, Lacal PM, Graziani G. Role of VEGFR-1 in melanoma acquired resistance to the BRAF inhibitor vemurafenib. Journal of Cellular and Molecular Medicine 24:465-475, 2020.
150. Lisi L, Chiavari M, Ciotti GMP , Lacal PM, Navarra P, Graziani G. DNA Inhibitors for the Treatment of Brain Tumors. Expert Opinion on Drug Metabolism and Toxicology 16:195-20, 72020.
151. Ceci C, Atzori MG, Lacal PM, Graziani G. Role of VEGFs/VEGFR-1 interplay in modulating tumor invasion: experimental evidence in different metastatic cancer models. International Journal of Molecular Sciences 21:1388, 2020.
152. Lisi L, Ciotti GMP, Chiavari M, Ruffini F, Lacal PM, Graziani G*, Navarra P. Vascular endothelial growth factor receptor 1 in glioblastoma‑associated microglia/macrophages. Oncology Reports 43:2083-2092, 2020. *Corresponding author
153. Sbardella D., Tundo G.R., Cunsolo V., Grasso G., Cascella R., Caputo V., Santoro A.M., Milardi D., Pecorelli A., Ciaccio C., Di Pierro D., Leoncini S., Campagnolo L., Pironi V., Oddone F., Manni P., Foti S., Giardina E., De Felice C., Hayek J., Curatolo P., Galasso C., Valacchi G., Coletta M., Graziani G., Marini S. Defective proteasome biogenesis into skin fibroblasts isolated from Rett syndrome subjects with MeCP2 non-sense mutations. Biochimica et Biophysica Acta - Molecular Basis of Disease 1866:165793, 2020.
154. Lacal PM, Atzori MG, Ruffini F, Scimeca M, Bonanno E, Cicconi R, Mattei M, Bernardini R, D'Atri S, Tentori L, Graziani G. Targeting the vascular endothelial growth factor receptor-1 by the monoclonal antibody D16F7 to increase the activity of immune checkpoint inhibitors against cutaneous melanoma. Pharmacological Research 159:104957, 2020.
155. Ceci C.*, Graziani G.*, Faraoni I., Cacciotti I. Strategies to improve ellagic acid bioavailability: from natural or semisynthetic derivatives to nanotechnological approaches based on innovative carriers. Nanotechnology 31:382001, 2020. *equally contributing authors
156. Tundo G.R.*, Sbardella D., Santoro A.M., Coletta A., Oddone F., Grasso G., Milardi D., Lacal P., Marini S., Purrello P., Graziani G.*, Coletta M*. The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges. Pharmacology & Therapeutics 213:107579, 2020. *Corresponding authors
157. Lisi L., Lacal P.M., Barbaccia M.L., Graziani G. Approaching Coronavirus Disease 2019: mechanisms of action of repurposed drugs with potential activity against SARS-CoV-2. Biochemical Pharmacology 180:114169, 2020.
158. Chiavari M., Ciotti G.M.P., Canonico F., Altieri F., Lacal P.M., Graziani G.*, Navarra P.i, Lisi L. PDIA3 expression in glioblastoma modulates macrophage/microglia pro-tumor activation. International Journal of Molecular Medicine 21:8214, 2020*Corresponding author
159. Ceci C. Atzori M.G., Lacal P.M., Graziani G. Targeting tumor-associated macrophages to increase the efficacy of immune checkpoint inhibitors: a glimpse into novel therapeutic approaches for metastatic melanoma. Cancers 12:3401, 2020.
160. Franzese O., Di Francesco A.M., Meco D., Graziani G., Cusano G., Riccardi R., Ruggiero A. hTERT transduction extends the lifespan of primary pediatric low-grade glioma cells while preserving the biological response to NGF. Pathology & Oncology Research 27:612375, 2021.
161. Bavetta M., Silvaggio D., Campione E., Sollena P., Formica V., Coletta D., Graziani G., Pucci Romano M.C., Roselli M., Peris K., Bianchi L. The Effects of Association of Topical Polydatin Improves the Preemptive Systemic Treatment on EGFR Inhibitors Cutaneous Adverse Reactions. Journal of Clinical Medicine 10:466, 2021.
162. Giansanti M., Karimi T., Faraoni I., Graziani G. High-Dose Vitamin C: Preclinical Evidence for Tailoring Treatment in Cancer Patients. Cancers (Basel) 13:1428, 2021.
163. Giansanti M., De Gabrieli A., Prete S.P., Ottone T., Divona M.D., Karimi T., Ciccarone F., Voso M.T., Graziani G*, Faraoni I.* Poly (ADP-ribose) polymerase inhibitors for arsenic trioxide-resistant acute promyelocytic leukemia: synergistic in vitro antitumor effects with hypomethylating agents or high-dose vitamin C. Journal of Pharmacology and Experimental Therapeutics 377:385-397, 2021. *equally contributing authors
164. Amin A., Farrukh A., Murali C., Soleimani A., Praz F., Graziani G., Brim H., Ashktorab H. Saffron and its major ingredients effect on colon cancer cells with mismatch repair deficiency and microsatellite instability. Molecules 26:3855, 2021.
165. Tundo G.R., Sbardella D., Oddone F., Kucriaeva A., Lacal P.M., Belogurov A., Graziani G.*, Marini S. At the Cutting Edge against Cancer: a Perspective on Immuno-proteasome and Immune Checkpoints Modulation as a potential therapeutic intervention Cancers 13:4852, 2021 *corresponding author.
166. Micheli L., Parisio C., Lucarini E., Vona A., Toti A., Pacini A., Mello T., Boccella S., Ricciardi F., Maione S., Graziani G.*, Lacal P.M., Failli P., Ghelardini C., Di Cesare Mannelli L. VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody. Journal of Experimental & Clinical Cancer Research 40:320, 2021 *corresponding author.
167. Lisi L., Lacal P.M., Martire M., Navarra P., Graziani G. Clinical experience with CTLA-4 blockade for cancer immunotherapy: From the monospecific monoclonal antibody ipilimumab to probodies and bispecific molecules targeting the tumor microenvironment. Pharmacological Research 175:105997, 2022.
168. Ceci C., Lacal P.M., Graziani G. Antibody-drug conjugates: Resurgent anticancer agents with multi-targeted therapeutic potential. Pharmacololy & Therapeutics 236:108106, 2022.
169. Tundo G.R., Sbardella D., Oddone F., Grasso G., Marini S., Atzori M.G., Santoro A.M., Milardi D., Bellia F., Macari G., Polticelli F., Graziani G., Cascio P., Parravano M.C., Coletta M. Insulin-degrading enzyme is a non proteasomal target of carfilzomib and affects the 20s proteasome inhibition by the drug. Biomolecules 12:315, 2022.
170. Graziani G., Lisi L., Tentori L., Navarra P. Monoclonal Antibodies to CTLA-4 with Focus on Ipilimumab. Experientia Supplementum 113:295-350, 2022.
171. Sbardella D., Tundo G.R., Mecchia A., Palumbo C., Atzori M.G., Levati L., Boccaccini A., Caccuri A.M., Cascio P., Lacal P.M., Graziani G., Varano M., Coletta M., Parravano M. A novel and atypical NF-KB pro-inflammatory program regulated by a CamKII-proteasome axis is involved in the early activation of Muller glia by high glucose. Cell Bioscience 12:108, 2022.
172. Franzese O., Graziani G. Role of PARP inhibitors in cancer immunotherapy: potential friends to immune activating molecules and foes to immune checkpoints. Cancers 14:5633, 2022.
173. Atzori M.G., Ceci C., Ruffini F., Scimeca M., Cicconi R., Mattei M., Lacal P.M., Graziani G. The anti-vascular endothelial growth factor receptor 1 (VEGFR-1) D16F7 monoclonal antibody inhibits melanoma adhesion to soluble VEGFR-1 and tissue invasion in response to placenta growth factor. Cancers 14:5578, 2022.
174. Tundo G.R., Cascio P., Milardi D., Santoro A.M., Graziani G., Lacal P.M., Bocedi A., Oddone F., Parravano M., Coletta A., Coletta M., Sbardella D. Targeting immunoproteasome in neurodegeneration: a glance to the future. Pharmacololy & Therapeutics 241:108329, 2023.
175. García-Chico C., López-Ortiz S., Peñín-Grandes S., Pinto-Fraga J., Valenzuela P.L., Emanuele E., Ceci C., Graziani G., Fiuza-Luces C., Lista S., Lucia A., Santos-Lozano A. Physical Exercise and the Hallmarks of Breast Cancer: A Narrative Review. Cancers 15:324, 2023.
176. Maresca C., Dello Stritto A., D’Angelo C., Petti E., Rizzo A., Vertecchi E., Berardinelli F., Bonanni L., Sgura A., Antoccia A., Graziani G., Biroccio A., Salvati E. PARP1 allows proper telomere replication through TRF1 poly (ADP-ribosyl)ation and helicase recruitment. Communications Biology 6:234, 2023.
177. Ruffini F., Ceci C., Atzori M.G., Caporali S., Levati L., Bonmassar L., Cappellini G.C.A., D'Atri S., Graziani G.*, Lacal P.M.* Targeting of PDGF-C/NRP-1 autocrine loop as a new strategy for counteracting the invasiveness of melanoma resistant to BRAF inhibitors. Pharmacological Research 192:106782, 2023. *equally contributing authors.
178. Boccaccini A., Cavaterra D., Carnevale C., Tanga L., Marini S., Bocedi A., Lacal P.M., Manni G., Graziani G., Sbardella D., Tundo G.R. Novel frontiers in neuroprotective therapies in glaucoma: Molecular and clinical aspects. Molecular Aspects of Medicine 94:101225; 2023.
179. Tundo G.R., Grasso G., Persico M., Tkachuk O., Bellia F., Bocedi A., Marini S., Parravano M., Graziani G., Fattorusso C., Sbardella D. The Insulin-Degrading Enzyme from Structure to Allosteric Modulation: New Perspectives for Drug Design. Biomolecules 13:1492, 2023.
180. Ceci C., García-Chico C., Atzori M.G., Lacal P.M., Lista S., Santos-Lozano A., Graziani G.*, Pinto-Fraga J. Impact of Physical Exercise on Melanoma Hallmarks: Current Status of Preclinical and Clinical Research. Journal of Cancer 15:1-19, 2024. *Corresponding author
181. Ceci C., Lacal P.M., Barbaccia M.L., Mercuri N.B., Graziani G.*, Ledonne A. The VEGFs/VEGFRs system in Alzheimer's and Parkinson’s diseases: Pathophysiological roles and therapeutic implications. Pharmacological Research 201:107101, 2024. *Corresponding author
182. Ceci C., Ruffini F., Falconi M., Atzori M.G., Falzon A., Lozzi F., Iacovelli F., D'Atri S., Graziani G., Lacal P.M. Pharmacological inhibition of PDGF-C/neuropilin-1 interaction: A novel strategy to reduce melanoma metastatic potential. Biomedicine & Pharmacotherapy 176:116766, 2024. *equally contributing authors.
183. Giansanti M., Ottone T., Travaglini S., Voso M.T., Graziani G. *, Faraoni I. Combination Treatment of Resistant Acute Promyelocytic Leukemia Cells with Arsenic Trioxide and Anti-Apoptotic Gene Inhibitors. Pharmaceuticals (Basel) 17:1529, 2024. *Co-corresponding author
184. Pinto-Fraga J., García-Chico C., Lista S., Lacal P.M., Carpenzano G., Salvati M., Santos-Lozano A., Graziani G.*, Ceci C.Protein kinase inhibitors as targeted therapy for glioblastoma: A meta-analysis of randomized controlled clinical trials. Pharmacological Research 212:107528, 2025. *Corresponding author
185. Toti A., Lucarini S.E, Ferrara V.,Parisio C., Ciampi C., Gerace E., Micheli L., Margiotta F., Venturi D., Mello T., Lacal P.M., Graziani G., Mannaioni G., Ghelardini C. , Di Cesare Mannelli L.The dual role of VEGF-A in a complex in vitro model of oxaliplatin-induced neurotoxicity: pain-related and neuroprotective effects. Neurotherapeutics 22:e00532, 2025.



Capitoli di libri

1. Graziani G., Grandori C., Macchi B., Pastore S., Bonmassar E., Giuliani-Bonmassar A. Interferon-mediated regulation of the target structures of normal or lymphoma cells. In Aaronson, S. A., Frati, L., Verna, R. (Eds.): Genetic and Phenotypic Markers of Tumors, pg. l99-2l0, Plenum Press, New York, 1984.
2. Aquino A., Roselli M., Munziata C., Graziani G., De Vecchis L. Attività “in vitro” dell’Interferon sulla funzione NK in presenza di 5-Fluorouracile e Acido Folinico. In: De Lorenzo A., Ceccanti M., Chiarioni T., Gasbarrini G. (Eds.): Neoplasie del tratto gastroenterico. Prevenzione, diagnosi e basi razionali della terapia. pg. 99-102, Editrice Compositori, Bologna, l987.
3. Grandori C., Graziani G., Perno F.C., D’Onofrio C., Bonmassar E. Immunopharmacology studies related to in vitro infection with HTLV-I. In: Poplack, D.G., Massimo L. and Cornaglia-Ferraris, P. (Eds.): The Role of Pharmacology in Pediatric Oncology. pg. 309-319, M. Nijoff and W. Jurk, Publishers, The Hague (Netherlands), 1987.
4. Graziani G., Ron D., Srivastava S., Eva A. Expression of human dbl-oncogene and proto-oncogene products in insect cells using a baculo-virus vector. In: Asherson, J., Colizzi, V., Marini, S., Pugliese, O. Annali Istituto Superiore di Sanità Roma, Vol.27, N.1: 115-122, 1991.
5. Graziani G., D’Atri S., Giuliani A., Franchi A., Piccioni D., Papa G., Bonmassar E. Cancer immunochemotherapy: preliminary studies with triazene compounds. In: “Combination Therapies 2” (A.L. Goldstein and E. Garaci eds.), pg. 135-147, Plenum Press, New York, 1993.
6. Faraoni I., Turriziani M., Masci G., De Vecchis, Shay J.S., Bonmassar E., Graziani G. Decline in telomerase activity as a measure of tumor cell killing by antineoplastic agents in vitro. in “The Year Book of Oncology”, pg. 13-14, Ed. Ozols R.F., Mosby, 1998.
7. D’Onofrio C., Graziani G., Bonmassar E. Farmaci immunomodulanti: immunostimolazione. In: Trattato Farmaci e Terapia, Immunofarmacologia e farmaci delle risposte infiammatorie. Cap 13, pag 177-195 UTET Torino 2002 (Ed. Di Rosa M., Fioretti M.C., Marcolongo F.R., Rugarli C.).
8. Graziani G. Principi di Chemioterapia, Volume 3, pg. 2695-2714, Cap. 236, Trattato di Medicina Interna Gasbarrini G., Ed. Verduci 2011.
9. Graziani G., Tentori L., Navarra P. Monoclonal antibodies to CTLA-4 with focus on ipilimumab. In: Interaction of Immune and Cancer Cells, Magdalena Klink, Ed. Springer, Vienna, 2013; pages: 233-258.
10. Graziani G. Nuovi antitumorali per la targeted therapy: pro e contro. In: Appunti di farmacologia dei sistemi. p. 37-62 UniversItalia; Roma, 2014. ISBN: 978-88-6507-674-3.
11. Graziani G. Risorse economiche, compatibilità cliniche, libertà prescrittiva. In: I farmaci e le sfide di una medicina a misura di paziente. p. 193-208 UniversItalia; Roma, 2015. ISBN 978-88-6507-844-0


Autorizzo il trattamento dei dati personali contenuti nel mio curriculum vitae in base al e al Regolamento UE 2016/679

Ai sensi e per gli effetti degli artt. 46 e 47 del DPR 28.12.2000 n.445, consapevole delle sanzioni penali richiamate dall’art.76 del medesimo, in caso di dichiarazioni mendaci e di formazione o uso di atti falsi, dichiaro di essere in possesso dei titoli e delle qualifiche indicati nel presente curriculum vitae et studiorum, riservandomi di produrre a richiesta titoli ed attestati utili alla valutazione della mia posizione che non siano già nel mio fascicolo personale

Roma, 18/06/2025

Produzione scientifica

2108/394266 - 2025 - Protein kinase inhibitors as targeted therapy for glioblastoma: a meta-analysis of randomized controlled clinical trials
Carpenzano, Giuseppe; Salvati, Maurizio; Graziani, Grazia; Ceci, Claudia - 01 - Articolo su rivista
rivista: PHARMACOLOGICAL RESEARCH (London : Academic Press) pp. - - issn: 1096-1186 - wos: WOS:001414399200001 (4) - scopus: 2-s2.0-85214318228 (3)

2108/396464 - 2024 - Combination treatment of resistant acute promyelocytic leukemia cells with arsenic trioxide and anti-apoptotic gene inhibitors
Ottone, Tiziana; Travaglini, Serena; Voso, Maria Teresa; Graziani, Grazia; Faraoni, Isabella - 01 - Articolo su rivista
rivista: PHARMACEUTICALS (Basel: MDPI, Molecular Diversity Preservation International, 2004-) pp. - - issn: 1424-8247 - wos: WOS:001367237700001 (0) - scopus: 2-s2.0-85210430402 (0)

2108/366185 - 2024 - Pharmacological inhibition of PDGF-C/neuropilin-1 interaction: A novel strategy to reduce melanoma metastatic potential
Ceci, Claudia; Ruffini, Federica; Falconi, Mattia; Atzori, Maria Grazia; Lozzi, Flavia; Iacovelli, Federico; Graziani, Grazia - 01 - Articolo su rivista
rivista: BIOMEDICINE & PHARMACOTHERAPY (Paris: Elsevier, 2002-) pp. - - issn: 1950-6007 - wos: WOS:001246277100001 (1) - scopus: 2-s2.0-85193815801 (2)

2108/360243 - 2024 - Impact of Physical Exercise on Melanoma Hallmarks: Current Status of Preclinical and Clinical Research
Ceci, Claudia; Atzori, Maria Grazia; Graziani, Grazia - 01 - Articolo su rivista
rivista: JOURNAL OF CANCER (Wyoming, N.S.W. : Ivyspring International Publisher, 2010-) pp. 1-19 - issn: 1837-9664 - wos: WOS:001119285000018 (4) - scopus: 2-s2.0-85187256030 (4)

2108/391545 - 2024 - The VEGFs/VEGFRs system in Alzheimer's and Parkinson's diseases: Pathophysiological roles and therapeutic implications
Ceci, Claudia; Barbaccia, Maria Luisa; Mercuri, Nicola Biagio; Graziani, Grazia; Ledonne, Ada - 01 - Articolo su rivista
rivista: PHARMACOLOGICAL RESEARCH (London : Academic Press) pp. - - issn: 1096-1186 - wos: WOS:001185805600001 (9) - scopus: 2-s2.0-85185439331 (8)

2108/322901 - 2023 - PARP1 allows proper telomere replication through TRF1 poly (ADP-ribosyl)ation and helicase recruitment
Graziani, Grazia - 01 - Articolo su rivista
rivista: COMMUNICATIONS BIOLOGY ([London]: Springer Nature) pp. 1-12 - issn: 2399-3642 - wos: WOS:000942913500004 (10) - scopus: 2-s2.0-85149323645 (13)

2108/322900 - 2023 - Targeting of PDGF-C/NRP-1 autocrine loop as a new strategy for counteracting the invasiveness of melanoma resistant to braf inhibitors
Ceci, Claudia; Atzori, Maria Grazia; Graziani, Grazia - 01 - Articolo su rivista
rivista: PHARMACOLOGICAL RESEARCH (London : Academic Press) pp. 106782- - issn: 1096-1186 - wos: WOS:001005392900001 (3) - scopus: 2-s2.0-85154034942 (4)

2108/350852 - 2023 - Novel frontiers in neuroprotective therapies in glaucoma: Molecular and clinical aspects
Boccaccini, Alessandra; Cavaterra, Dario; Marini, Stefano; Bocedi, Alessio; Manni, Gianluca; Graziani, Grazia; Sbardella, Diego; Tundo, Grazia Raffaella - 01 - Articolo su rivista
rivista: MOLECULAR ASPECTS OF MEDICINE (Oxford: Elsevier Science Limited Oxford; New York: Pergamon Press 1976-) pp. 1-16 - issn: 0098-2997 - wos: WOS:001125670600001 (9) - scopus: 2-s2.0-85177883717 (10)

2108/350851 - 2023 - The Insulin-Degrading Enzyme from Structure to Allosteric Modulation: New Perspectives for Drug Design
Tundo, Grazia Raffaella; Bocedi, Alessio; Marini, Stefano; Graziani, Grazia; Sbardella, Diego - 01 - Articolo su rivista
rivista: BIOMOLECULES (Basel: MDPI) pp. 1-28 - issn: 2218-273X - wos: WOS:001094178600001 (5) - scopus: 2-s2.0-85175034051 (5)

2108/313329 - 2023 - Physical Exercise and the Hallmarks of Breast Cancer: A Narrative Review
Ceci, Claudia; Graziani, Grazia - 01 - Articolo su rivista
rivista: CANCERS (Basel: MDPI) pp. - - issn: 2072-6694 - wos: WOS:000909552600001 (19) - scopus: 2-s2.0-85146011761 (28)

2108/313328 - 2023 - Targeting immunoproteasome in neurodegeneration: a glance to the future
Tundo, Grazia Raffaella; Graziani, Grazia; Bocedi, Alessio; Sbardella, Diego - 01 - Articolo su rivista
rivista: PHARMACOLOGY & THERAPEUTICS (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. - - issn: 0163-7258 - wos: WOS:000917903900001 (8) - scopus: 2-s2.0-85145716835 (8)

2108/310219 - 2022 - Role of PARP Inhibitors in Cancer Immunotherapy: Potential Friends to Immune Activating Molecules and Foes to Immune Checkpoints
Franzese, Ornella; Graziani, Grazia - 01 - Articolo su rivista
rivista: CANCERS (Basel: MDPI) pp. 5633- - issn: 2072-6694 - wos: WOS:000887104500001 (16) - scopus: 2-s2.0-85142662482 (17)

2108/283786 - 2022 - Clinical experience with CTLA-4 blockade for cancer immunotherapy: from the monospecific monoclonal antibody ipilimumab to probodies and bispecific molecules targeting the tumor microenvironment
Graziani, Grazia - 01 - Articolo su rivista
rivista: PHARMACOLOGICAL RESEARCH (Attuale:ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 24-28 OVAL RD, LONDON, ENGLAND, NW1 7DX Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. - - issn: 1043-6618 - wos: WOS:000793141100001 (55) - scopus: 2-s2.0-85120699953 (60)

2108/287579 - 2022 - Antibody-drug conjugates: resurgent anticancer agents with multi-targeted therapeutic potential
Ceci, Claudia; Graziani, Grazia - 01 - Articolo su rivista
rivista: PHARMACOLOGY & THERAPEUTICS (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 1-39 - issn: 0163-7258 - wos: WOS:000767237900007 (24) - scopus: 2-s2.0-85122686329 (30)

2108/290143 - 2022 - Insulin-degrading enzyme is a non proteasomal target of carfilzomib and affects the 20S proteasome inhibition by the drug
Tundo, Grazia Raffaella; Sbardella, Diego; Marini, Stefano; Graziani, Grazia - 01 - Articolo su rivista
rivista: BIOMOLECULES (Basel: MDPI) pp. 1-20 - issn: 2218-273X - wos: WOS:000774102900001 (3) - scopus: 2-s2.0-85124583163 (3)

2108/310216 - 2022 - The Anti-Vascular Endothelial Growth Factor Receptor 1 (VEGFR-1) D16F7 Monoclonal Antibody Inhibits Melanoma Adhesion to Soluble VEGFR-1 and Tissue Invasion in Response to Placenta Growth Factor
Atzori, Maria Grazia; Ceci, Claudia; Scimeca, Manuel; Cicconi, Rosella; Mattei, Maurizio; Graziani, Grazia - 01 - Articolo su rivista
rivista: CANCERS (Basel: MDPI) pp. 5578- - issn: 2072-6694 - wos: WOS:000887142500001 (6) - scopus: 2-s2.0-85142655268 (6)

2108/311662 - 2022 - A novel and atypical NF-KB pro-inflammatory program regulated by a CamKII-proteasome axis is involved in the early activation of Muller glia by high glucose
Sbardella, Diego; Tundo, Grazia Raffaella; Palumbo, Camilla; Atzori, Maria Grazia; Caccuri, Anna Maria; Graziani, Grazia; Coletta, Massimiliano - 01 - Articolo su rivista
rivista: CELL & BIOSCIENCE (London : BioMed Central) pp. - - issn: 2045-3701 - wos: WOS:000826163500001 (13) - scopus: 2-s2.0-85134310077 (14)

2108/275646 - 2021 - hTERT Transduction Extends the Lifespan of Primary Pediatric Low-Grade Glioma Cells While Preserving the Biological Response to NGF
Franzese, Ornella; Graziani, Grazia - 01 - Articolo su rivista
rivista: PATHOLOGY ONCOLOGY RESEARCH (Attuale: -HUNGARY, BUDAPEST: ARANYI LAJOS FOUNDATION, SEMMELWEIS UNIVERSITY Precedente: -Akademiai Kiado:Prielle Kornelia U-19, H 1117 Budapest Hungary:011 36 1 4648222, 011 36 1 4648282, 011 36 1 4648282, EMAIL: journals@akkrt.hu, kiss.s@akkrt.hu, INTERNET: http://www.akkrt.hu/en/, Fax: 011 36 1 4648221) pp. - - issn: 1219-4956 - wos: WOS:000640374000001 (5) - scopus: 2-s2.0-85104349305 (6)

2108/282567 - 2021 - VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody
Graziani, Grazia - 01 - Articolo su rivista
rivista: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (London : BioMed Central) pp. 320- - issn: 1756-9966 - wos: WOS:000707354800001 (38) - scopus: 2-s2.0-85117347384 (38)

2108/265339 - 2021 - The effects of association of topical polydatin improves the preemptive systemic treatment on EGFR inhibitors cutaneous adverse reactions
Campione, Elena; Formica, Vincenzo; Graziani, Grazia; Roselli, Mario; Bianchi, Luca - 01 - Articolo su rivista
rivista: JOURNAL OF CLINICAL MEDICINE (MDPI Publishing, Basel, Switzerland) pp. 1-8 - issn: 2077-0383 - wos: WOS:000615336800001 (6) - scopus: 2-s2.0-85114068265 (8)

2108/282556 - 2021 - Saffron and its major ingredients’ effect on colon cancer cells with mismatch repair deficiency and microsatellite instability
Graziani, Grazia - 01 - Articolo su rivista
rivista: MOLECULES (Basel: MDPI Berlin: Springer, 1996-) pp. 3855- - issn: 1420-3049 - wos: WOS:000671131800001 (68) - scopus: 2-s2.0-85109136656 (73)

2108/282565 - 2021 - At the cutting edge against cancer: A perspective on immunoproteasome and immune checkpoints modulation as a potential therapeutic intervention
Tundo, Grazia Raffaella; Sbardella, Diego; Graziani, Grazia; Marini, Stefano - 01 - Articolo su rivista
rivista: CANCERS (Basel: MDPI) pp. 4852- - issn: 2072-6694 - wos: WOS:000709541500001 (17) - scopus: 2-s2.0-85115825084 (18)

2108/275644 - 2021 - High-Dose Vitamin C: Preclinical Evidence for Tailoring Treatment in Cancer Patients
Faraoni, Isabella; Graziani, Grazia - 01 - Articolo su rivista
rivista: CANCERS (Basel: MDPI) pp. 1-21 - issn: 2072-6694 - wos: WOS:000634359200001 (21) - scopus: 2-s2.0-85102709625 (22)

2108/275642 - 2021 - Poly(ADP-Ribose) polymerase inhibitors for arsenic trioxide-resistant acute promyelocytic leukemia: synergistic in vitro antitumor effects with hypomethylating agents or high-dose vitamin C
Ottone, Tiziana; Ciccarone, Fabio; Voso, Maria Teresa; Graziani, Grazia; Faraoni, Isabella - 01 - Articolo su rivista
rivista: THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS () pp. 385-397 - issn: 1521-0103 - wos: (0) - scopus: 2-s2.0-85107711668 (9)

2108/255178 - 2020 - The proteasome as a druggable target with multiple therapeutic potentialities: cutting and non-cutting edges
Tundo, Grazia Raffaella; Marini, Stefano; Graziani, Grazia; Coletta, Massimiliano - 01 - Articolo su rivista
rivista: PHARMACOLOGY & THERAPEUTICS (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. - - issn: 0163-7258 - wos: WOS:000564184400004 (70) - scopus: 2-s2.0-85088019708 (77)

2108/248974 - 2020 - Role of VEGFs/VEGFR-1 signaling and its inhibition in modulating tumor invasion: experimental evidence in different metastatic cancer models
Ceci, Claudia; Graziani, Grazia - 01 - Articolo su rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:000522524400215 (154) - scopus: 2-s2.0-85079620754 (171)

2108/226879 - 2020 - Role of VEGFR-1 in melanoma acquired resistance to the BRAF inhibitor vemurafenib
Atzori, Maria Grazia; Ceci, Claudia; Barbaccia, Maria Luisa; Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (Bucharest : Foundation for Cellular and Molecular Medicine.) pp. 465-475 - issn: 1582-1838 - wos: WOS:000498039100001 (38) - scopus: 2-s2.0-85075470108 (40)

2108/259751 - 2020 - Targeting tumor-associated macrophages to increase the efficacy of immune checkpoint inhibitors: a glimpse into novel therapeutic approaches for metastatic melanoma
Ceci, Claudia; Graziani, Grazia - 01 - Articolo su rivista
rivista: CANCERS (Basel: MDPI) pp. - - issn: 2072-6694 - wos: WOS:000592777600001 (47) - scopus: 2-s2.0-85096315020 (51)

2108/256603 - 2020 - Strategies to improve ellagic acid bioavailability: from natural or semisynthetic derivatives to nanotechnological approaches based on innovative carriers
Ceci, Claudia; Graziani, Grazia; Faraoni, Isabella; Cacciotti, Ilaria - 01 - Articolo su rivista
rivista: NANOTECHNOLOGY (Bristol, United Kingdom: IOP Publishing Limited) pp. 382001- - issn: 0957-4484 - wos: WOS:000549144200001 (44) - scopus: 2-s2.0-85088206815 (47)

2108/256570 - 2020 - Approaching coronavirus disease 2019: Mechanisms of action of repurposed drugs with potential activity against SARS-CoV-2
Barbaccia, Maria Luisa; Graziani, Grazia - 01 - Articolo su rivista
rivista: BIOCHEMICAL PHARMACOLOGY (-Oxford, United Kingdom: Elsevier Science Limited -London ; New York : Pergamon Press, 1958-) pp. 114169- - issn: 0006-2952 - wos: WOS:000579310000008 (21) - scopus: 2-s2.0-85089233265 (26)

2108/256590 - 2020 - Targeting the vascular endothelial growth factor receptor-1 by the monoclonal antibody D16F7 to increase the activity of immune checkpoint inhibitors against cutaneous melanoma
Scimeca, Manuel; Bonanno, Elena; Cicconi, Rosella; Mattei, Maurizio; Bernardini, Roberta; Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: PHARMACOLOGICAL RESEARCH (Attuale:ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 24-28 OVAL RD, LONDON, ENGLAND, NW1 7DX Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 104957- - issn: 1043-6618 - wos: WOS:000566432900006 (26) - scopus: 2-s2.0-85086947392 (28)

2108/245871 - 2020 - Defective proteasome biogenesis into skin fibroblasts isolated from Rett syndrome subjects with MeCP2 non-sense mutations
Sbardella, Diego; Tundo, Grazia Raffaella; Cascella, Raffaella; Caputo, Valerio; Ciaccio, Chiara; Di Pierro, Donato; Campagnolo, Luisa; Giardina, Emiliano; Curatolo, Paolo; Galasso, Cinzia; Coletta, Massimiliano; Graziani, Grazia; Marini, Stefano - 01 - Articolo su rivista
rivista: BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE (Amsterdam: Elsevier) pp. 165793- - issn: 1879-260X - wos: WOS:000536131300016 (12) - scopus: 2-s2.0-85083336812 (12)

2108/248970 - 2020 - Vascular endothelial growth factor receptor 1 in glioblastoma-associated microglia/macrophages
Graziani, Grazia - 01 - Articolo su rivista
rivista: ONCOLOGY REPORTS (Editore attuale: PROFESSOR D A SPANDIDOS, 1, S MERKOURI ST, EDITORIAL OFFICE,, ATHENS, GREECE, 116 35 PRECEDENTE: National Hellenic Research Foundation:48 Vas Constatinou Avenue, Athens 11635 Greece:011 30 1 7241505, Fax: 011 30 1 7241505) pp. 2083-2092 - issn: 1021-335X - wos: WOS:000530363200031 (15) - scopus: 2-s2.0-85079679513 (18)

2108/248972 - 2020 - DNA inhibitors for the treatment of brain tumors
Graziani, Grazia - 01 - Articolo su rivista
rivista: EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (-London : Taylor & Francis -London United Kingdom:Informa Healthcare -London : Ashley Publications, 2005-) pp. 195-207 - issn: 1742-5255 - wos: WOS:000516926400001 (4) - scopus: 2-s2.0-85082342487 (4)

2108/259753 - 2020 - PDIA3 Expression in Glioblastoma Modulates Macrophage/Microglia Pro-Tumor Activation
Graziani, Grazia - 01 - Articolo su rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 1-22 - issn: 1422-0067 - wos: WOS:000589129400001 (31) - scopus: 2-s2.0-85095787821 (32)

2108/217760 - 2019 - Targeting ADP-ribosylation by PARP inhibitors in acute myeloid leukaemia and related disorders
Faraoni, Isabella; Voso, Maria Teresa; Lo Coco, Francesco; Graziani, Grazia - 01 - Articolo su rivista
rivista: BIOCHEMICAL PHARMACOLOGY (-Oxford, United Kingdom: Elsevier Science Limited -London ; New York : Pergamon Press, 1958-) pp. 133-148 - issn: 0006-2952 - wos: WOS:000506423700016 (19) - scopus: 2-s2.0-85064951647 (21)

2108/226882 - 2019 - Cytotoxicity and differentiating effect of the poly(ADP-ribose) polymerase inhibitor olaparib in myelodysplastic syndromes
Faraoni, Isabella; Tentori, Lucio; Di Veroli, Ambra; Lo Coco, Francesco; Graziani, Grazia; Voso, Maria Teresa - 01 - Articolo su rivista
rivista: CANCERS (Basel: MDPI) pp. 1373- - issn: 2072-6694 - wos: WOS:000489719000158 (13) - scopus: 2-s2.0-85074406246 (16)

2108/224878 - 2019 - Effects of Glutathione Transferase-Targeting Nitrobenzoxadiazole Compounds in Relation to PD-L1 Status in Human Melanoma Cells
Sciarretta, Francesca; Fulci, Chiara; Palumbo, Camilla; Tentori, Lucio; Graziani, Grazia; Caccuri, Anna Maria - 01 - Articolo su rivista
rivista: CHEMOTHERAPY (S Karger AG:Allschwilerstrasse 10, CH-4009 Basel Switzerland:011 41 61 3061111, EMAIL: orders@karger.ch, INTERNET: http://www.karger.com, Fax: 011 41 61 3061234) pp. 138-145 - issn: 0009-3157 - wos: WOS:000501814700004 (6) - scopus: 2-s2.0-85074343924 (6)

2108/226886 - 2019 - On the Horizon: Targeting Next-Generation Immune Checkpoints for Cancer Treatment
Tundo, Grazia Raffaella; Sbardella, Diego; Graziani, Grazia; Marini, Stefano - 01 - Articolo su rivista
rivista: CHEMOTHERAPY (Basel: S. Karger, 1968-) pp. 62-80 - issn: 1421-9794 - wos: WOS:000492959100002 (33) - scopus: 2-s2.0-85070591387 (35)

2108/210674 - 2018 - Experimental evidence of the antitumor, antimetastatic and antiangiogenic activity of ellagic acid
Ceci, Claudia; Tentori, Lucio; Miano, Roberto; Graziani, Grazia - 01 - Articolo su rivista
rivista: NUTRIENTS (Basel, Switzerland: Molecular Diversity Preservation International (MDPI)) pp. 1756- - issn: 2072-6643 - wos: WOS:000451547700194 (185) - scopus: 2-s2.0-85056671409 (202)

2108/191755 - 2018 - EGFR heterogeneity and implications for therapeutic intervention in glioblastoma.
Graziani, Grazia - 01 - Articolo su rivista
rivista: NEURO-ONCOLOGY (First or current publisher Charlottesville, VA : Carden Jennings Pub., [1999- Intervening publisher Durham, NC : Duke University Press Current or last publisher Oxford, UK : Oxford University Press) pp. 743-752 - issn: 1523-5866 - wos: WOS:000432685600004 (230) - scopus: 2-s2.0-85047747064 (241)

2108/219675 - 2018 - Role of BRCA mutations in cancer treatment with poly(ADP-ribose) polymerase (PARP) inhibitors
Faraoni, Isabella; Graziani, Grazia - 01 - Articolo su rivista
rivista: CANCERS (Basel: MDPI) pp. 487- - issn: 2072-6694 - wos: WOS:000455199200025 (169) - scopus: 2-s2.0-85058438937 (177)

2108/195625 - 2018 - Beneficial and Detrimental Effects of Antiretroviral Therapy on HIV-Associated Immunosenescence
Franzese, Ornella; Barbaccia, Maria Luisa; Graziani, Grazia - 01 - Articolo su rivista
rivista: CHEMOTHERAPY (S Karger AG:Allschwilerstrasse 10, CH-4009 Basel Switzerland:011 41 61 3061111, EMAIL: orders@karger.ch, INTERNET: http://www.karger.com, Fax: 011 41 61 3061234) pp. 64-75 - issn: 0009-3157 - wos: WOS:000432178400004 (12) - scopus: 2-s2.0-85044050170 (12)

2108/191774 - 2018 - The Anti-Vascular Endothelial Growth Factor Receptor-1 Monoclonal Antibody D16F7 Inhibits Glioma Growth and Angiogenesis In Vivo.
Atzori, Maria Grazia; Tentori, Lucio; Ruffini, Simona; Ceci, Claudia; Bonanno, Elena; Scimeca, Manuel; Graziani, Grazia - 01 - Articolo su rivista
rivista: THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS () pp. 77-86 - issn: 1521-0103 - wos: WOS:000422708500009 (24) - scopus: 2-s2.0-85039561624 (25)

2108/195629 - 2018 - Drug-induced xenogenization of tumors: A possible role in the immune control of malignant cell growth in the brain?
Franzese, Ornella; Battaini, Fiorenzo Maria; Graziani, Grazia; Tentori, Lucio; Barbaccia, Maria Luisa; Aquino, Angelo; Roselli, Mario; Torino, Francesco - 01 - Articolo su rivista
rivista: PHARMACOLOGICAL RESEARCH (Attuale:ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 24-28 OVAL RD, LONDON, ENGLAND, NW1 7DX Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 1-6 - issn: 1043-6618 - wos: WOS:000432759100001 (6) - scopus: 2-s2.0-85043571868 (6)

2108/201369 - 2018 - The poly(ADP-ribose) polymerase inhibitor olaparib induces up-regulation of death receptors in primary acute myeloid leukemia blasts by NF-κB activation.
Faraoni, Isabella; Irno Consalvo, Maria Antonietta; Lavorgna, Serena; Lo Coco, Francesco; Graziani, Grazia - 01 - Articolo su rivista
rivista: CANCER LETTERS (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. 127-138 - issn: 0304-3835 - wos: WOS:000430625100015 (23) - scopus: 2-s2.0-85044143399 (26)

2108/203407 - 2018 - Therapeutic implication of vascular endothelial growth factor receptor-1 (VEGFR-1) targeting in cancer cells and tumor microenvironment by competitive and non-competitive inhibitors
Graziani, Grazia - 01 - Articolo su rivista
rivista: PHARMACOLOGICAL RESEARCH (London : Academic Press) pp. 97-107 - issn: 1096-1186 - wos: WOS:000452572300011 (136) - scopus: 2-s2.0-85052870158 (149)

2108/191776 - 2017 - Platelet-derived growth factor-C promotes human melanoma aggressiveness through activation of neuropilin-1.
Graziani, Grazia; Atzori, Maria Grazia - 01 - Articolo su rivista
rivista: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. - - issn: 1949-2553 - wos: WOS:000410790500007 (18) - scopus: 2-s2.0-85032797857 (20)

2108/191778 - 2017 - Macrophages/microglia in glioblastoma: A Zelig-like story of changing phenotypes
Graziani, Grazia - 01 - Articolo su rivista
rivista: TRANSLATIONAL CANCER RESEARCH (Hong Kong : Pioneer Bioscience Publishing Company) pp. - - issn: 2218-676X - wos: WOS:000409347400041 (0) - scopus: 2-s2.0-85028502023 (0)

2108/190156 - 2017 - The anti-vascular endothelial growth factor receptor-1 monoclonal antibody D16F7 inhibits invasiveness of human glioblastoma and glioblastoma stem cells
Tentori, Lucio; Ceci, Claudia; Bonanno, Elena; Scimeca, Manuel; Graziani, Grazia - 01 - Articolo su rivista
rivista: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (London : BioMed Central) pp. 106-120 - issn: 1756-9966 - wos: WOS:000407365500001 (47) - scopus: 2-s2.0-85027713261 (46)

2108/170935 - 2017 - Type 5 phosphodiesterase regulates glioblastoma multiforme aggressiveness and clinical outcome
Cesarini, Valeriana; Graziani, Grazia; Rossi, Pellegrino; Jannini, Emmanuele Angelo Francesco; Dolci, Susanna - 01 - Articolo su rivista
rivista: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. - - issn: 1949-2553 - wos: WOS:000395692000068 (29) - scopus: 2-s2.0-85013434299 (32)

2108/170755 - 2017 - Exploiting Microglial Functions for the Treatment of Glioblastoma
Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: CURRENT CANCER DRUG TARGETS (Hilversum : Bentham Science Publishers) pp. 267-281 - issn: 1873-5576 - wos: WOS:000400685800007 (44) - scopus: 2-s2.0-84930886228 (32)

2108/190148 - 2017 - Modulation of GDF11 expression and synaptic plasticity by age and training
D'arcangelo, Giovanna; Faraoni, Isabella; Tancredi, Virginia; Graziani, Grazia; Grimaldi, Paola; Tentori, Lucio - 01 - Articolo su rivista
rivista: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. 57991-58002 - issn: 1949-2553 - wos: WOS:000408941900007 (13) - scopus: 2-s2.0-85029035540 (15)

2108/183282 - 2017 - High-dose ascorbate and arsenic trioxide selectively kill acute myeloid leukemia and acute promyelocytic leukemia blasts in vitro
Lo Coco, Francesco; Catalano, Gianfranco; Graziani, Grazia; Voso, Maria Teresa - 01 - Articolo su rivista
rivista: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. 32550-32565 - issn: 1949-2553 - wos: WOS:000401767700014 (40) - scopus: 2-s2.0-85019243469 (46)

2108/183286 - 2017 - Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment
Botta, Lorenzo; Graziani, Grazia - 01 - Articolo su rivista
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 3626-3635 - issn: 0022-2623 - wos: WOS:000401403100008 (28) - scopus: 2-s2.0-85018888932 (31)

2108/170769 - 2016 - Activity against melanoma of an anti-vascular endothelial growth factor receptor-1 (VEGFR-1) monoclonal antibody that does not hamper ligand binding
Graziani, Grazia; Tentori, Lucio; Scimeca, Manuel; Dorio, Annalisa Susanna; Atzori, Maria Grazia; Bonanno, Elena - 02 - Intervento a convegno
congresso: Melanoma Bridge Meeting 2016, 30 November-3 December 2016, Naples, Italy. (Napoli)

2108/170653 - 2016 - Placenta growth factor and neuropilin-1 collaborate in promoting melanoma aggressiveness
Graziani, Grazia - 01 - Articolo su rivista
rivista: INTERNATIONAL JOURNAL OF ONCOLOGY (National Hellenic Research Foundation:48 Vas Constatinou Avenue, Athens 11635 Greece:011 30 1 7241505, Fax: 011 30 1 7241505Editore attuale:PROFESSOR D A SPANDIDOS, 1, S MERKOURI ST, EDITORIAL OFFICE,, ATHENS, GREECE, 116 35. Editore precedente:Editorial Academy of the International Journal of Oncology.) pp. 1581-1589 - issn: 1019-6439 - wos: WOS:000372567100029 (36) - scopus: 2-s2.0-84959020084 (36)

2108/170655 - 2016 - EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation
Graziani, Grazia - 01 - Articolo su rivista
rivista: NEURO-ONCOLOGY (Carden Jennings Pub.) pp. 1-12 - issn: 1522-8517 - wos: WOS:000387331500008 (92) - scopus: 2-s2.0-85006870204 (92)

2108/170657 - 2016 - Editorial
Graziani, Grazia - 01 - Articolo su rivista
rivista: CHEMOTHERAPY (S Karger AG:Allschwilerstrasse 10, CH-4009 Basel Switzerland:011 41 61 3061111, EMAIL: orders@karger.ch, INTERNET: http://www.karger.com, Fax: 011 41 61 3061234) pp. 1-2 - issn: 0009-3157 - wos: WOS:000366735400001 (0) - scopus: 2-s2.0-84951573876 (0)

2108/170757 - 2016 - Antitumor activity of a novel anti-vascular endothelial growth factor receptor-1 monoclonal antibody that does not interfere with ligand binding
Graziani, Grazia; Tentori, Lucio; Scimeca, Manuel; Dorio, Annalisa Susanna; Atzori, Maria Grazia; Bonanno, Elena - 01 - Articolo su rivista
rivista: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. 72868-72885 - issn: 1949-2553 - wos: WOS:000387452100037 (25) - scopus: 2-s2.0-84995785881 (26)

2108/170759 - 2016 - Ellagic acid inhibits bladder cancer invasiveness and in vivo tumor growth
Ceci, Claudia; Tentori, Lucio; Atzori, Maria Grazia; Bonanno, Elena; Scimeca, Manuel; Cicconi, Rosella; Mattei, Maurizio; Vespasiani, Giuseppe; Miano, Roberto; Graziani, Grazia - 01 - Articolo su rivista
rivista: NUTRIENTS (Basel, Switzerland: Molecular Diversity Preservation International (MDPI)) pp. 744- - issn: 2072-6643 - wos: WOS:000388666400075 (80) - scopus: 2-s2.0-84996538690 (92)

2108/170661 - 2016 - VIII edizione Rang & Dale's Pharmacology, edizione italiana Rang & Dale Farmacologia Edra LSWR Edizioni 9788821440397.
Graziani, Grazia - 05 - Curatele

2108/170908 - 2015 - A novel water-soluble nitrobenzoxadiazole is highly effective against vemurafenib-resistant human melanoma cells
De Luca, Anastasia; Graziani, Grazia; Muzi, Alessia; Bonanno, Elena; Tentori, Lucio; Caccuri, Anna Maria - 02 - Intervento a convegno
congresso: EACR-AACR-SIC Special Conference 20-23 June 2015 Florence, Italy (Firenze)
libro: EACR-AACR-SIC Special Conference on Anticancer drug action and drug resistance: from cancer biology to the clinic - ()

2108/168967 - 2015 - I FARMACI E LA FRAGILITA’
Barbaccia, Maria Luisa; Franzese, Ornella; Graziani, Grazia; Macchi, Beatrice - 03 - Contributo in libro
libro: I farmaci e le sfide di una medicina a misura di paziente - (978-88-6507-674-3)

2108/170765 - 2015 - Neuropilin-1 expressing melanoma cells as a model to study the aggressiveness of metastatic melanoma
Graziani, Grazia; Tentori, Lucio - 02 - Intervento a convegno
rivista: JOURNAL OF TRANSLATIONAL MEDICINE (London: BioMed Central-Springer London) pp. 1-2 - issn: 1479-5876 - wos: (0) - scopus: 2-s2.0-84928729141 (0)
congresso: Melanoma Bridge Meeting 2014, 3-6 December 2014 (napoli)

2108/291845 - 2015 - Nitrobenzoxadiazoles exert anti-melanoma activity modulating the MAPK/JNK signalling
De Luca, Anastasia; Graziani, Grazia; Caccuri, Anna Maria - 02 - Intervento a convegno
congresso: EACR-AACR-SIC Special Conference “FROM CANCER BIOLOGY TO THE CLINIC” (Firenze)
libro: EACR-AACR-SIC Special Conference on Anticancer drug action and drug resistance: from cancer biology to the clinic - ()

2108/113695 - 2015 - A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib
Graziani, Grazia; De Luca, Anastasia; Scimeca, Manuel; Ceci, Claudia; Bonanno, Elena; Tentori, Lucio; Caccuri, Anna Maria - 01 - Articolo su rivista
rivista: BIOCHEMICAL PHARMACOLOGY (-Oxford, United Kingdom: Elsevier Science Limited -London ; New York : Pergamon Press, 1958-) pp. 16-27 - issn: 0006-2952 - wos: WOS:000353858800002 (32) - scopus: 2-s2.0-84930886228 (32)

2108/99416 - 2015 - Cilengitide down-modulates invasiveness and vasculogenic mimicry of neuropilin-1 expressing melanoma cells through the inhibition of αvβ5 integrin.
Graziani, Grazia; Tentori, Lucio - 01 - Articolo su rivista
rivista: INTERNATIONAL JOURNAL OF CANCER (Hoboken N.J.: Wiley New York NY: Wiley-Liss) pp. - - issn: 0020-7136 - wos: WOS:000347705200007 (54) - scopus: 2-s2.0-84944964277 (63)

2108/170659 - 2015 - Risorse economiche, compatibilità cliniche, libertà prescrittiva. In: I farmaci e le sfide di una medicina a misura di paziente.
Graziani, Grazia - 03 - Contributo in libro
libro: Risorse economiche, compatibilità cliniche, libertà prescrittiva. In: I farmaci e le sfide di una medicina a misura di paziente. - (978-88-6507-844-0)

2108/151167 - 2015 - Neuropilin-1 as Therapeutic Target for Malignant Melanoma.
Graziani, Grazia - 01 - Articolo su rivista
rivista: FRONTIERS IN ONCOLOGY (Lausanne : Frontiers Editorial Office, 2011-) pp. - - issn: 2234-943X - wos: WOS:000359141500001 (63) - scopus: 2-s2.0-84934277040 (65)

2108/106813 - 2015 - BRCA1, PARP1 and γH2AX in acute myeloid leukemia: Role as biomarkers of response to the PARP inhibitor olaparib.
Faraoni, Isabella; Dolci, Susanna; Venditti, Adriano; Graziani, Grazia; Lo Coco, Francesco - 01 - Articolo su rivista
rivista: BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 462-472 - issn: 0925-4439 - wos: WOS:000349739000009 (54) - scopus: 2-s2.0-84920089489 (58)

2108/106989 - 2014 - Capitoli 37, 38, 39, 55 di Farmacologia IX Ed. Italiana di Katzung B.G. Masters S.B. Trevor A.J. (XII Ed. Americana)
Graziani, Grazia - 03b - Traduzione in libro
rivista: Farmacologia IX Ed. Italiana di Katzung B.G. Masters S.B. Trevor A.J. () pp. - - issn: - wos: (0) - scopus: (0)
libro: Farmacologia generale e clinica - KATZUNG B.G., MASTERS S.B., TREVOR A.J. (9788829926510)

2108/168975 - 2014 - INVECCHIAMENTO, IMMUNITÀ E FARMACI
Barbaccia, Maria Luisa; Franzese, Ornella; Graziani, Grazia; Macchi, Beatrice - 03 - Contributo in libro
libro: APPUNTI DI FARMACOLOGIA DEI SISTEMI - (978-88-6507-674-3)

2108/106811 - 2014 - Capitoli 37, 38, 39, 55 di Farmacologia IX Ed. Italiana di Katzung B.G. Masters S.B. Trevor A.J. (XII Ed. Americana)
Graziani, Grazia - 05 - Curatele

2108/97359 - 2014 - Nuovi antitumorali per la targeted therapy: pro e contro
Graziani, Grazia - 03 - Contributo in libro
libro: Appunti di farmacologia dei sistemi - (978-88-6507-674-3)

2108/120050 - 2014 - Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers.
Graziani, Grazia; Tentori, Lucio; Desideri, Alessandro - 01 - Articolo su rivista
rivista: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (London : BioMed Central) pp. 71- - issn: 1756-9966 - wos: WOS:000344697200001 (0) - scopus: 2-s2.0-84908213301 (0)

2108/84887 - 2014 - Pharmacological inhibition of poly(ADP-ribose) polymerase-1 modulates resistance of human glioblastoma stem cells to temozolomide.
Tentori, Lucio; Muzi, Alessia; Ciccarone, Fabio; Graziani, Grazia - 01 - Articolo su rivista
rivista: BMC CANCER (London: BioMed Central, [2001]-) pp. 1-12 - issn: 1471-2407 - wos: WOS:000333420000001 (71) - scopus: 2-s2.0-84897573804 (73)

2108/91347 - 2014 - Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers.
Graziani, Grazia; Tentori, Lucio; Desideri, Alessandro - 01 - Articolo su rivista
rivista: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (London : BioMed Central) pp. 71- - issn: 1756-9966 - wos: WOS:000344697200001 (3) - scopus: 2-s2.0-84908213301 (4)

2108/106589 - 2014 - Monoclonal antibodies to CTLA-4 with focus on ipilimumab
Graziani, Grazia; Tentori, Lucio - 03 - Contributo in libro
libro: Interaction of Immune and Cancer Cells - ()

2108/82987 - 2013 - Challenging resistance mechanisms to therapies for metastatic melanoma
Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: TRENDS IN PHARMACOLOGICAL SCIENCES (Elsevier Trends Journals:An Imprint of Elsevier Science Limited, The Boulevard, Langford Lane, Kidlington, Oxford 0X5 1GB United Kingdom:011 44 1865 843000, 011 44 1865 843699, Fax: 011 44 1865 843010) pp. 656-666 - issn: 0165-6147 - wos: WOS:000329771800003 (82) - scopus: 2-s2.0-84889091074 (89)

2108/82967 - 2013 - Platelet-derived growth factor C and calpain-3 are modulators of human melanoma cell invasiveness.
Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: ONCOLOGY REPORTS (Editore attuale: PROFESSOR D A SPANDIDOS, 1, S MERKOURI ST, EDITORIAL OFFICE,, ATHENS, GREECE, 116 35 PRECEDENTE: National Hellenic Research Foundation:48 Vas Constatinou Avenue, Athens 11635 Greece:011 30 1 7241505, Fax: 011 30 1 7241505) pp. 2887-2896 - issn: 1021-335X - wos: WOS:000330226200047 (21) - scopus: 2-s2.0-84892384905 (21)

2108/79130 - 2013 - Influence of MLH1 on colon cancer sensitivity to poly(ADP-ribose) polymerase inhibitor combined with irinotecan.
Tentori, Lucio; Dolci, Susanna; Graziani, Grazia - 01 - Articolo su rivista
rivista: INTERNATIONAL JOURNAL OF ONCOLOGY (National Hellenic Research Foundation:48 Vas Constatinou Avenue, Athens 11635 Greece:011 30 1 7241505, Fax: 011 30 1 7241505Editore attuale:PROFESSOR D A SPANDIDOS, 1, S MERKOURI ST, EDITORIAL OFFICE,, ATHENS, GREECE, 116 35. Editore precedente:Editorial Academy of the International Journal of Oncology.) pp. 210-218 - issn: 1019-6439 - wos: WOS:000321023100025 (10) - scopus: 2-s2.0-84879619017 (11)

2108/79129 - 2013 - MSH3 expression does not influence the sensitivity of colon cancer HCT116 cell line to oxaliplatin and poly(ADP-ribose) polymerase (PARP) inhibitor as monotherapy or in combination.
Tentori, Lucio; Dolci, Susanna; Graziani, Grazia - 01 - Articolo su rivista
rivista: CANCER CHEMOTHERAPY AND PHARMACOLOGY (Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229) pp. 117-125 - issn: 0344-5704 - wos: WOS:000320889300012 (14) - scopus: 2-s2.0-84879775148 (14)

2108/106135 - 2013 - PARP-1 modulates amyloid beta peptide-induced neuronal damage.
Graziani, Grazia - 01 - Articolo su rivista
rivista: PLOS ONE (San Francisco, CA : Public Library of Science) pp. - - issn: 1932-6203 - wos: WOS:000325025200005 (57) - scopus: 2-s2.0-84884573236 (67)

2108/83007 - 2013 - PARP Inhibitors in Cancer Therapy: Magic Bullets but Moving Targets.
Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: FRONTIERS IN ONCOLOGY (Lausanne : Frontiers Editorial Office, 2011-) pp. 1-5 - issn: 2234-943X - wos: (0) - scopus: 2-s2.0-84891044156 (29)

2108/79147 - 2013 - GITRL (Glucocorticoid-Induced TNF receptor family-Related Ligand) triggering up-regulates VCAM-1 and ICAM-1 and promotes leukocyte adhesion.
Graziani, Grazia - 01 - Articolo su rivista
rivista: THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS () pp. 164-172 - issn: 1521-0103 - wos: WOS:000324583600017 (25) - scopus: 2-s2.0-84884646965 (28)

2108/106988 - 2012 - Parte V- Farmaci per il trattamento di infezioni, tumori e malattie immunologiche; Capitoli: 49, Principi di chemioterapia antimicrobica; 50, Farmaci antibatterici; 51, Farmaci antivirali; 52, Farmaci antifungini; 53, Farmaci antiprotozoari; 54, Farmaci anti-elmintici; 55, Farmaci antitumorali. Farmacologia, VII edizione Italiana di Rang and Dale's Pharmacology (VII ed. Inglese); p.616-680.
Graziani, Grazia - 03b - Traduzione in libro
rivista: Titolo originale del libro: Rang and Dale's Pharmacology (VII ed. Inglese);Section 5: Drugs used for the treatment of infections, cancer and immunological disorders 49. Basic principles of antimicrobial chemotherapy 50. Antibacterial drugs 51. Antiviral drugs 52. Antifungal drugs 53. Antiprotozoal drugs 54. Anthelminthic drugs 55. Anticancer drugs Section () pp. - - issn: - wos: (0) - scopus: (0)

2108/77764 - 2012 - NF-κB is activated in response to temozolomide in an AKT-dependent manner and confers protection against the growth suppressive effect of the drug.
Graziani, Grazia - 01 - Articolo su rivista
rivista: JOURNAL OF TRANSLATIONAL MEDICINE (London: BioMed Central-Springer London) pp. - - issn: 1479-5876 - wos: WOS:000313838800001 (35) - scopus: 2-s2.0-84871372401 (38)

2108/106767 - 2012 - Parte V- Farmaci per il trattamento di infezioni, tumori e malattie immunologiche (capitoli 49, 50, 51, 52, 53, 54, 55) Farmacologia VII edizione Italiana di Rang and Dale's Pharmacology (VII ed. Inglese). p. 616-680.
Graziani, Grazia - 05 - Curatele

2108/71127 - 2012 - DNA damaging agents can induce celll cycle arrest in different phases of mitosis
Vernole, Patrizia; Tentori, Lucio; Volpi, Antonio; Graziani, Grazia - 02 - Intervento a convegno
congresso: FISV congress (Roma)
libro: Program and abstracts of the 12th FISV Congress : University of Rome La Sapienza, September 24-27, 2012 - ()

2108/67993 - 2012 - Targeted therapy for brain tumours: role of PARP inhibitors
Graziani, Grazia; Tentori, Lucio - 01 - Articolo su rivista
rivista: CURRENT CANCER DRUG TARGETS (Hilversum: Bentham Science Publishers) pp. 218-236 - issn: 1568-0096 - wos: WOS:000300633600005 (24) - scopus: 2-s2.0-84857130173 (23)

2108/77765 - 2012 - Reduced proficiency in homologous recombination underlies the high sensitivity of embryonal carcinoma testicular germ cell tumors to Cisplatin and poly (adp-ribose) polymerase inhibition
Graziani, Grazia; Barchi, Marco - 01 - Articolo su rivista
rivista: PLOS ONE (San Francisco, CA : Public Library of Science) pp. 51563-51563 - issn: 1932-6203 - wos: WOS:000313236200133 (81) - scopus: 2-s2.0-84871229659 (83)

2108/54622 - 2012 - Ipilimumab: A novel immunostimulatory monoclonal antibody for the treatment of cancer
Graziani, Grazia; Tentori, Lucio - 01 - Articolo su rivista
rivista: PHARMACOLOGICAL RESEARCH (Attuale:ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 24-28 OVAL RD, LONDON, ENGLAND, NW1 7DX Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 9-22 - issn: 1043-6618 - wos: WOS:000301868200003 (121) - scopus: 2-s2.0-84856014065 (136)

2108/10917 - 2011 - The glutathione transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) increases temozolomide efficacy against malignant melanoma
Tentori, Lucio; Dorio, Annalisa Susanna; Muzi, Alessia; Vernole, Patrizia; Federici, Giorgio; Caccuri, Anna Maria; Graziani, Grazia - 01 - Articolo su rivista
rivista: EUROPEAN JOURNAL OF CANCER (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 1219-1230 - issn: 0959-8049 - wos: WOS:000291232400012 (34) - scopus: 2-s2.0-79955539543 (38)

2108/47530 - 2011 - Capitolo 37: Ormoni ipotalamici e ipofisari; Capitolo 38: Tiroide e farmaci antitiroidei; Capitolo 39: Gli steroidi corticosurrenalici e antagonisti; Capitolo 40: Ormoni delle gonadi; Capitolo 43: Antibiotici beta-lattamici ed altri antibiotici attivi sulla parete o della membrana cellulari; Capitolo 48: Agenti antimicotici; Capitolo 55: Immunofarmacologia
Graziani, Grazia - 03b - Traduzione in libro
rivista: Farmacologia generale e clinica / di Bertram G. Katzung. 8. edizione italiana () pp. - - issn: - wos: (0) - scopus: (0)
libro: Farmacologia generale e clinica - Katzung, BG (978-88-299-2049-5)

2108/50919 - 2011 - Role of DNA repair pathways in the control of common fragile sites expression.
Vernole, Patrizia; Volpi, Antonio; Tentori, Lucio; Graziani, Grazia - 02 - Intervento a convegno
congresso: 24 congresso annuale dell’AICC, (Roma)

2108/8935 - 2011 - Expression of the soluble vascular endothelial growth factor receptor-1 in cutaneous melanoma: role in tumour progression
Graziani, Grazia - 01 - Articolo su rivista
rivista: BRITISH JOURNAL OF DERMATOLOGY ([Oxford]: Oxford University Press [Oxford]: [Blackwell Science].) pp. 1061-1070 - issn: 1365-2133 - wos: WOS:000289898200001 (27) - scopus: 2-s2.0-79955423690 (27)

2108/51089 - 2011 - Common fragile sites in colon cancer cell lines: role of mismatch repair, RAD51 and poly(ADP-ribose) polymerase-1
Vernole, Patrizia; Muzi, Alessia; Volpi, Antonio; Terrinoni, Alessandro; Dorio, Annalisa Susanna; Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: MUTATION RESEARCH (Amsterdam: Elsevier) pp. 40-48 - issn: 0027-5107 - wos: WOS:000292343100006 (10) - scopus: 2-s2.0-79957700521 (10)

2108/51135 - 2011 - Trattato di Medicina Interna Gasbarrini G. Volume 3
Graziani, Grazia - 03 - Contributo in libro
libro: Principi di Chemioterapia - (88-7620-846-1)

2108/68951 - 2011 - PARP inhibitors for cancer treatment
Graziani, Grazia - 02 - Intervento a convegno
congresso: New Drugs in Cancer Therapy - Mediterranean School of Oncology (MSO) ()

2108/68895 - 2011 - Poly(ADP-ribose) polymerase (PARP) inhibitors as modulators of tumor drug resi stance to chemotherapy
Tentori, Lucio; Vernole, Patrizia; Graziani, Grazia - 02 - Intervento a convegno
congresso: 24° Convegno Annuale dell’Associazione Italiana di Colture Cellulari (ONLUS-AICC) (Roma)

2108/51210 - 2011 - Principi di Chemioterapia - Trattato di Medicina Interna Gasbarrini Volume 3
Graziani, Grazia - 03 - Contributo in libro
libro: Principi di Chemioterapia - (88-7620-846-1)

2108/8925 - 2011 - Poly(ADP-ribose) polymerase signaling of topoisomerase 1-dependent DNA damage in carcinoma cells
Dorio, Annalisa Susanna; Muzi, Alessia; Graziani, Grazia - 01 - Articolo su rivista
rivista: BIOCHEMICAL PHARMACOLOGY (-Oxford, United Kingdom: Elsevier Science Limited -London ; New York : Pergamon Press, 1958-) pp. 194-202 - issn: 0006-2952 - wos: WOS:000286156500002 (14) - scopus: 2-s2.0-78650177865 (18)

2108/21985 - 2011 - Differential effects on mitosis of DNA damaging agents with distinct mechanisms
Vernole, Patrizia; Tentori, Lucio; Volpi, Antonio; Graziani, Grazia - 02 - Intervento a convegno
congresso: W.Bernhard workshop (Riga (Lettonia))

2108/68593 - 2011 - Cortagine, a Selective CRH-R1 Agonist, Inhibits Cell Proliferation of Human Endometrial Adenocarcinoma Cells
Graziani, Grazia - 02 - Intervento a convegno
congresso: 58th Annual Scientific Meeting Reproductive Scieneces (Miami, FL, USA)

2108/51975 - 2011 - PARP inhibitors for cancer treatment: an update on current clinical trials.
Graziani, Grazia; Tentori, Lucio - 02 - Intervento a convegno
congresso: XXIV Italian Meeting on ADP-ribosylation Reactions. (Torre del Greco (Naples), Italy)
libro: Proceedings of the XXIV Italian Meeting on ADP-ribosylation Reactions - ()

2108/68956 - 2011 - NF-kB is activated in response to temozolomide and confers protection against drug-induced cell growth inhibition
Graziani, Grazia - 02 - Intervento a convegno
congresso: 53th Annual Meeting of the Italian Cancer Society Back to the future: Translational cancer research from bedside to bench and back (Torino)

2108/8680 - 2011 - Placenta growth factor induces melanoma resistance to temozolomide through a mechanism that involves the activation of the transcription factor NF-κB
Muzi, Alessia; Graziani, Grazia - 01 - Articolo su rivista
rivista: INTERNATIONAL JOURNAL OF ONCOLOGY (National Hellenic Research Foundation:48 Vas Constatinou Avenue, Athens 11635 Greece:011 30 1 7241505, Fax: 011 30 1 7241505Editore attuale:PROFESSOR D A SPANDIDOS, 1, S MERKOURI ST, EDITORIAL OFFICE,, ATHENS, GREECE, 116 35. Editore precedente:Editorial Academy of the International Journal of Oncology.) pp. 241-247 - issn: 1019-6439 - wos: WOS:000286293000028 (22) - scopus: 2-s2.0-78650841055 (20)

2108/8937 - 2011 - Exogenous Control of the Expression of Group I CD1 Molecules Competent for Presentation of Microbial Nonpeptide Antigens to Human T Lymphocytes
Aquino, Angelo; Graziani, Grazia; Franzese, Ornella; Prete, Salvatore - 01 - Articolo su rivista
rivista: CLINICAL & DEVELOPMENTAL IMMUNOLOGY (-NEW YORK:HINDAWI PUBLISHING CORPORATION, -Abingdon : Taylor & Francis Health Sciences, 2003-) pp. 790460- - issn: 1740-2522 - wos: WOS:000295584800001 (4) - scopus: 2-s2.0-79959233123 (4)

2108/10700 - 2010 - The glutathione s-transferase inhibitor 6-(7-Nitro-2,1,3-BenzoxaDiazol-4-ylthio)Hexanol (NBDHEX) increases temozolomide efficacy against malignant melanoma.
Tentori, Lucio; Caccuri, Anna Maria; Graziani, Grazia - 02 - Intervento a convegno
congresso: “Lost in Translation: bridging the gap between cancer research and effective therapies” (Roma)

2108/8934 - 2010 - Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent.
Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: CURRENT CANCER DRUG TARGETS (Hilversum: Bentham Science Publishers) pp. 368-383 - issn: 1568-0096 - wos: WOS:000279868900002 (20) - scopus: 2-s2.0-77953668745 (18)

2108/10697 - 2010 - PARPs signalling of TOP1-dependent DNA damage in carcinoma cells.
Graziani, Grazia - 02 - Intervento a convegno
congresso: XXIII Convegno Nazionale.“I Processi di ADP-ribosilazione” (Roma)

2108/8933 - 2010 - Pharmacological Inhibition of Poly(ADP-ribose) Polymerase (PARP) Activity in PARP-1 Silenced Tumour Cells Increases Chemosensitivity to Temozolomide and to a N3-Adenine Selective Methylating Agent.
Tentori, Lucio; Muzi, Alessia; Dorio, Annalisa Susanna; Graziani, Grazia - 01 - Articolo su rivista
rivista: CURRENT CANCER DRUG TARGETS (Hilversum: Bentham Science Publishers) pp. 368-383 - issn: 1568-0096 - wos: WOS:000279868900002 (20) - scopus: 2-s2.0-77953668745 (18)

2108/10670 - 2010 - PARP-1 signaling of Topoisomerase 1-dependent DNA damage in carcinoma cells.
Graziani, Grazia - 02 - Intervento a convegno
congresso: PARP meeting 2010 (Zurich)

2108/10704 - 2010 - PlGF induces melanoma resistance to temozolomide through a mechanism that involves NF-kB activation.
Graziani, Grazia - 02 - Intervento a convegno
congresso: “Lost in Translation: bridging the gap between cancer research and effective therapies” (Roma)

2108/40311 - 2010 - Detection of circulating tumor cells is improved by drug-induced antigen up-regulation: preclinical and clinical studies
Graziani, Grazia; Prete, Salvatore; Formica, Vincenzo; De Vecchis, Liana; Torino, Francesco; Roselli, Mario; Aquino, Angelo - 01 - Articolo su rivista
rivista: ANTICANCER RESEARCH (Kapandriti: International Institute of Anticancer Research, 1995 Earliest publisher: Καπανδρίτι: Ιωάννης Γ. Δεληνάσιος, 1981-1995 Kapandriti: Iōannīs G. Delīnasios, 1981-1995) pp. 4721-4730 - issn: 0250-7005 - wos: WOS:000285237100048 (4) - scopus: 2-s2.0-78650248498 (4)

2108/8932 - 2010 - PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy
Tentori, Lucio; Graziani, Grazia; Orlandi, Augusto - 01 - Articolo su rivista
rivista: ONCOGENE (Macmillan Magazines Limited:Porters South Crinian Street, London N1 9XW United Kingdom:011 44 207 8334000, 011 44 171 8434982, Fax: 011 44 207 812358) pp. 6280-6293 - issn: 0950-9232 - wos: WOS:000284601700009 (101) - scopus: 2-s2.0-78649507645 (114)

2108/42030 - 2010 - Novel Glutathione S-Transferase Inhibitor Enhances Temozolomide Efficacy Against Malignant Melanoma 52nd Annual Meeting of the Italian Cancer Society. Lost in translation: bridging the gap between cancer research and effective therapies
Tentori, Lucio; Dorio, Annalisa Susanna; Muzi, Alessia; Caccuri, Anna Maria; Graziani, Grazia - 02 - Intervento a convegno
congresso: Annual Meeting of the Italian Cancer Society. Lost in translation: bridging the gap between cancer research and effective therapies (Roma)

2108/68948 - 2010 - PARP-1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy
Tentori, Lucio; Graziani, Grazia; Orlandi, Augusto - 02 - Intervento a convegno
congresso: Lost in Translation: bridging the gap between cancer research and effective therapies”, 52nd Annual Meeting of the Italian Cancer Society (Roma)

2108/19942 - 2010 - Homologous recombination but not poly(adp-ribose) polymerase-1 is involved in the control of common fragile sites stability
Vernole, Patrizia; Volpi, Antonio; Terrinoni, Alessandro; Tentori, Lucio; Graziani, Grazia - 02 - Intervento a convegno
congresso: Instabilità genetica e riparazione del DNA: nuovi paradigmi per la ricerca translazionale (Roma)

2108/22475 - 2009 - DNA repair defects and chromosomal fragile sites expression.
Vernole, Patrizia; Volpi, Antonio; Graziani, Grazia - 02 - Intervento a convegno
congresso: ICEM-10th International Conference on Environmental Mutagens (Firenze, Italia)

2108/41513 - 2009 - Evidence of the crucial role of the linker domain on the catalytic activity of human topoisomerase I by experimental and simulative characterization of the Lys681Ala mutant
Chillemi, Giovanni; Graziani, Grazia; Tentori, Lucio; Muzi, Alessia; Desideri, Alessandro - 01 - Articolo su rivista
rivista: NUCLEIC ACIDS RESEARCH (Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485 Editore precedente: Information Retrieval ltd., London) pp. 6849-6858 - issn: 0305-1048 - wos: WOS:000271819900018 (27) - scopus: 2-s2.0-73349101566 (29)

2108/46927 - 2009 - Recent Approaches to Improve the Antitumor Efficacy of Temozolomide.
Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: CURRENT MEDICINAL CHEMISTRY (Bentham Science Publishers BV:PO Box 7917, Exec Ste Y 26, Saif Zone Sharjah Uae:011 971 6 5571132, EMAIL: benthams@emirates.net.ae, INTERNET: http://www.bentham.org, Fax: 011 971 6 5571134) pp. 245-257 - issn: 0929-8673 - wos: WOS:000263294700010 (79) - scopus: 2-s2.0-62349087854 (85)

2108/68057 - 2009 - Traduzione e revisione capitoli di 38, 39, 40, 43, 48 e 56 della 10a edizione 2007 Inglese Basic and Clinical Pharmacology McGraw-Hill - Katzung corrispondente alla 7a edizione 2009 Italiana Piccin
Graziani, Grazia - 03b - Traduzione in libro
rivista: Capitolo 38: Tiroide e farmaci antitiroidei; capitolo 39: Gli steroidi corticosurrenalici e antagonisti; Capitolo 40: Ormoni delle gonadi; Capitolo 43: Antibiotici beta-lattamici ed altri antibiotici attivi sulla parete o sulla membrana cellulari; Capitolo 48: Agenti antimicotici; Capitolo 56: Immunofarmacologia () pp. - - issn: - wos: (0) - scopus: (0)

2108/39369 - 2009 - Inhibition of homologous recombination by treatment with BVDU (brivudin) or by RAD51 silencing increases chromosomal damage induced by bleomycin in mismatch repair-deficient tumour cells
Vernole, Patrizia; Volpi, Antonio; Terrinoni, Alessandro; Graziani, Grazia - 01 - Articolo su rivista
rivista: MUTATION RESEARCH (Amsterdam: Elsevier) pp. 39-47 - issn: 0027-5107 - wos: WOS:000266364100006 (8) - scopus: 2-s2.0-65049090766 (9)

2108/45230 - 2009 - Inhibition of poly(ADP-ribose) polymerase (PARP) increases the therapeutic efficacy of the G-quadruplex ligand RHPS4/irinotecan combination in colon cancer xenografts
Tentori, Lucio; Graziani, Grazia; Orlandi, Augusto - 02 - Intervento a convegno
congresso: AACR-NCI-EORTC International Conference: “Molecular Targets and Cancer Therapeutics” (Boston)
libro: Proceeding of the AACR-NCI-EORTC International Conference: “Molecular Targets and Cancer Therapeutics” - ()

2108/46277 - 2009 - Pharmacological inhibition of poly(ADP-ribose) polymerase activity down-regulates the expression of syndecan-4 and Id-1 in endothelial cells
Tentori, Lucio; Muzi, Alessia; Dorio, Annalisa Susanna; Graziani, Grazia - 01 - Articolo su rivista
rivista: INTERNATIONAL JOURNAL OF ONCOLOGY (National Hellenic Research Foundation:48 Vas Constatinou Avenue, Athens 11635 Greece:011 30 1 7241505, Fax: 011 30 1 7241505Editore attuale:PROFESSOR D A SPANDIDOS, 1, S MERKOURI ST, EDITORIAL OFFICE,, ATHENS, GREECE, 116 35. Editore precedente:Editorial Academy of the International Journal of Oncology.) pp. 861-872 - issn: 1019-6439 - wos: WOS:000263573600030 (22) - scopus: 2-s2.0-64549160302 (22)

2108/46316 - 2008 - Stable depletion of poly (ADP-ribose) polymerase-1 reduces in vivo melanoma growth and increases chemosensitivity
Tentori, Lucio; Muzi, Alessia; Dorio, Annalisa Susanna; Graziani, Grazia - 01 - Articolo su rivista
rivista: EUROPEAN JOURNAL OF CANCER (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 1302-1314 - issn: 0959-8049 - wos: WOS:000257636900027 (39) - scopus: 2-s2.0-44449115048 (42)

2108/22486 - 2008 - 5(2-bromovinyl)-2’-deoxyuridine (BVDU), increases the amount of chromatid breaks induced by bleomycin in mismatch repair deficient tumor cells by inhibiting homologous recombination
Vernole, Patrizia; Graziani, Grazia; Volpi, Antonio - 02 - Intervento a convegno
congresso: ELSO Meeting , (Nizza,Francia)

2108/44220 - 2008 - Stable depletion of poly (ADP-ribose) polymerase-1 reduces in vivo melanoma growth and increases chemosensitivity to temozolomide. 17th International Symposium on poly(ADP-ribosyl)ation.
Tentori, Lucio; Muzi, Alessia; Dorio, Annalisa Susanna; Graziani, Grazia - 02 - Intervento a convegno
congresso: 17th International Symposium on poly(ADP-ribosyl)ation. (Tucson, Arizona)
libro: proceedings of the 17th International Symposium on poly(ADP-ribosyl)ation. PARP 2008 - ()

2108/44229 - 2008 - Pharmacological inhibition of poly (ADP-ribose) polymerase (PARP) activity down-regulates the expression of syndecan-4 and Id-1 in endothelial cells and increases temozolomide sensitivity of PARP-1 silenced melanoma cells.
Dorio, Annalisa Susanna; Muzi, Alessia; Tentori, Lucio; Graziani, Grazia - 02 - Intervento a convegno
congresso: Incontro sui processi di ADP-ribosilazione (Santa Maria Imbaro, Chieti)

2108/47532 - 2008 - Inhibition of endothelial cell migration and angiogenesis by a vascular endothelial growth factor receptor-1 derived peptide
Dorio, Annalisa Susanna; Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: EUROPEAN JOURNAL OF CANCER (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 1914-1921 - issn: 0959-8049 - wos: WOS:000259466000025 (22) - scopus: 2-s2.0-49549085264 (21)

2108/46314 - 2008 - The integrin antagonist cilengitide increases the antitumor activity of temozolomide against malignant melanoma
Tentori, Lucio; Dorio, Annalisa Susanna; Muzi, Alessia; Graziani, Grazia - 01 - Articolo su rivista
rivista: ONCOLOGY REPORTS (Editore attuale: PROFESSOR D A SPANDIDOS, 1, S MERKOURI ST, EDITORIAL OFFICE,, ATHENS, GREECE, 116 35 PRECEDENTE: National Hellenic Research Foundation:48 Vas Constatinou Avenue, Athens 11635 Greece:011 30 1 7241505, Fax: 011 30 1 7241505) pp. 1039-1043 - issn: 1021-335X - wos: WOS:000254496100030 (41) - scopus: 2-s2.0-43849087019 (47)

2108/38507 - 2008 - Valproic acid activity in androgen-sensitive and -insensitive human prostate cancer cells
Graziani, Grazia; Muzi, Alessia; Sica, Giuseppe - 01 - Articolo su rivista
rivista: INTERNATIONAL JOURNAL OF ONCOLOGY (National Hellenic Research Foundation:48 Vas Constatinou Avenue, Athens 11635 Greece:011 30 1 7241505, Fax: 011 30 1 7241505Editore attuale:PROFESSOR D A SPANDIDOS, 1, S MERKOURI ST, EDITORIAL OFFICE,, ATHENS, GREECE, 116 35. Editore precedente:Editorial Academy of the International Journal of Oncology.) pp. 1293-1303 - issn: 1019-6439 - wos: WOS:000256191100016 (22) - scopus: 2-s2.0-48149087630 (23)

2108/44187 - 2008 - In vivo anti-angiogenic potential of a peptide that inhibits VEGFR-1 homodimerization and PlGF-induced migration of endothelial cells.
Tentori, Lucio; Graziani, Grazia - 02 - Intervento a convegno
congresso: Euroconference on Angiogenesis (Paris)
libro: Proceedings of the 8th Euroconference on Angiogenesis - ()

2108/47281 - 2007 - Immortalized endothelial cells
Graziani, Grazia - 06 - Brevetti e altre privative registrate

2108/38009 - 2007 - Poly(ADP-ribose) polymerase (PARP) inhibition or PARP-1 gene deletion reduces angiogenesis
Tentori, Lucio; Muzi, Alessia; Dorio, Annalisa Susanna; Graziani, Grazia - 01 - Articolo su rivista
rivista: EUROPEAN JOURNAL OF CANCER (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 2124-2133 - issn: 0959-8049 - wos: WOS:000250186100022 (133) - scopus: 2-s2.0-34548514842 (134)

2108/45836 - 2007 - Targeting angiogenesis with poly(ADP-ribose) polymerase inhibitors
Muzi, Alessia; Dorio, Annalisa Susanna; Tentori, Lucio; Graziani, Grazia - 02 - Intervento a convegno
congresso: Convegno Nazionale “I Processi di ADP-ribosilazione” (Monte Sant'Angelo, Napoli)

2108/68664 - 2007 - Poly (ADP-ribose) polymerase (PARP) inhibition or PARP-1 gene deletion reduces angiogenesis
Tentori, Lucio; Graziani, Grazia - 02 - Intervento a convegno
congresso: 98th AACR Annual Meeting (Los Angeles, CA, USA)

2108/41668 - 2007 - VEGFR-1 derived peptide specifically inhibits PlGF and VEGF-B-induced migration of endothelial cells and in vivo angiogenesis.
Tentori, Lucio; Graziani, Grazia - 02 - Intervento a convegno
congresso: 49° Congresso della Società Italiana di Cancerologia., Aviano-Pordenone (Aviano-Pordenone)
libro: Proceedings of the 49° Congresso della Società Italiana di Cancerologia - ()

2108/37995 - 2007 - Evidence that corticotropin-releasing hormone inhibits cell growth of human breast cancer cells via the activation of CRH-R1 receptor subtype.
Graziani, Grazia; Tentori, Lucio; Muzi, Alessia - 01 - Articolo su rivista
rivista: Molecular Cellular Endocrinology () pp. 44-49 - issn: - wos: WOS:000244157800006 (46) - scopus: 2-s2.0-33846216433 (47)

2108/36887 - 2007 - BCG-infected adherent mononuclear cells release cytokines that regulate group 1 CD1 molecule expression
Graziani, Grazia; Franzese, Ornella - 01 - Articolo su rivista
rivista: INTERNATIONAL IMMUNOPHARMACOLOGY (Tokyo ; Oxford ; New York ; London ; Amsterdam ; Shannon ; Paris : Eldevier : Elsevier) pp. 321-332 - issn: 1567-5769 - wos: WOS:000244621400006 (5) - scopus: 2-s2.0-33846579210 (5)

2108/38012 - 2007 - Doping with growth hormone/IGF-1, anabolic steroids or erythropoietin: is there a cancer risk?
Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: PHARMACOLOGICAL RESEARCH (Attuale:ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 24-28 OVAL RD, LONDON, ENGLAND, NW1 7DX Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 359-369 - issn: 1043-6618 - wos: WOS:000246936800002 (50) - scopus: 2-s2.0-34147183927 (57)

2108/43093 - 2006 - Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma.
Tentori, Lucio; Muzi, Alessia; Dorio, Annalisa Susanna; Graziani, Grazia - 01 - Articolo su rivista
rivista: THE FASEB JOURNAL (Federation of American Societies for Experimental Biology (FASEB):9650 Rockville Pike, Room L-2310:Bethesda, MD 20814:(800)433-2732, (301)530-7027, EMAIL: staff@dues.faseb.org, INTERNET: http://www.faseb.org, Fax: (301)571-5728, (301)530-7001) pp. 1709-1711 - issn: 0892-6638 - wos: WOS:000240266600023 (89) - scopus: 2-s2.0-33845672155 (100)

2108/40399 - 2006 - Oral administration of poly(ADP-ribose) polymerase inhibitor prevents intestinal damage induced by irinotecan and enhances the efficacy of irinotecan and temozolomide combination against colon carcinoma.
Tentori, Lucio; Graziani, Grazia - 02 - Intervento a convegno
rivista: CANCER RESEARCH (American Association of Cancer Research:150 South Independence Mall West, #826:Philadelphia, PA 19106:(215)440-9300, EMAIL: pubs@aacr.org, INTERNET: http://www.aacr.org, Fax: (215)440-7228) pp. - - issn: 0008-5472 - wos: WOS:000454606204278 (0) - scopus: (0)
congresso: Annual Meeting American Association for Cancer Research. Washington, DC, USA, 1-5 April 2006, 97th (Washington, DC, USA)
libro: Proceedings of the 97th Annual Meeting American Association for Cancer Research. Washington, DC, USA, 1-5 April 2006 - ()

2108/43098 - 2006 - Corticotropin-releasing hormone receptor-1 in human endometrial cancer.
Graziani, Grazia; Tentori, Lucio - 01 - Articolo su rivista
rivista: ONCOLOGY REPORTS (Editore attuale: PROFESSOR D A SPANDIDOS, 1, S MERKOURI ST, EDITORIAL OFFICE,, ATHENS, GREECE, 116 35 PRECEDENTE: National Hellenic Research Foundation:48 Vas Constatinou Avenue, Athens 11635 Greece:011 30 1 7241505, Fax: 011 30 1 7241505) pp. 375-379 - issn: 1021-335X - wos: WOS:000234781800014 (12) - scopus: 2-s2.0-33744463944 (13)

2108/35542 - 2006 - Role of the mismatch repair system and p53 in the clastogenicity and cytotoxicity induced by bleomycin
Vernole, Patrizia; Tentori, Lucio; Argentin, Gabriella; Cicchetti, Rosadele; Graziani, Grazia - 01 - Articolo su rivista
rivista: MUTATION RESEARCH (Amsterdam: Elsevier) pp. 63-77 - issn: 0027-5107 - wos: WOS:000235601500007 (17) - scopus: 2-s2.0-31644432771 (17)

2108/41935 - 2005 - Clinical perspectives of PARP inhibitors
Graziani, Grazia - 01 - Articolo su rivista
rivista: PHARMACOLOGICAL RESEARCH (Attuale:ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 24-28 OVAL RD, LONDON, ENGLAND, NW1 7DX Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 109-118 - issn: 1043-6618 - wos: WOS:000229973300012 (119) - scopus: 2-s2.0-19444362951 (137)

2108/40308 - 2005 - Inhibition of endothelial cell migration by vascular endothelial growth factor receptor-1 peptides.
Tentori, Lucio; Graziani, Grazia - 02 - Intervento a convegno
congresso: 5th ESH Interdisciplinary Euroconference on Angiogenesis (Sitges, Spain)
libro: Proceedings of the 5th ESH Interdisciplinary Euroconference on Angiogenesis, Sitges, Spain - ()

2108/40306 - 2005 - Oral administration of the PARP inhibitor GPI 15427 increases the activity of anticancer drugs with different mechanisms of action
Tentori, Lucio; Graziani, Grazia - 02 - Intervento a convegno
congresso: XVIII Convegno Nazionale I processi di ADP-ribosilazione. XIV International meeting ADP ribosylation reactions Verona 3-4 Ottobre 2005. European Journal of Histochemistry Vol 49(4) 2005 pag 399 ISSN 1121-760X (Verona)
libro: Proceedings of the XVIII Convegno Nazionale I processi di ADP-ribosilazione and XIV International meeting ADP ribosylation reactions - ()

2108/41651 - 2005 - Poly(ADP-ribose) glycohydrolase inhibitor as chemosensitiser of malignant melanoma for temozolomide
Tentori, Lucio; Muzi, Alessia; Graziani, Grazia - 01 - Articolo su rivista
rivista: EUROPEAN JOURNAL OF CANCER (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 2948-2957 - issn: 0959-8049 - wos: WOS:000234155500032 (45) - scopus: 2-s2.0-28244465243 (45)

2108/41955 - 2005 - Gli inibitori della poli (ADP-ribosio) polimerasi (PARP) per superare la chemioresistenza a metilanti e inibitori di topoisomerasi I
Tentori, Lucio; Muzi, Alessia; Graziani, Grazia - 02 - Intervento a convegno
congresso: Convegno annuale Associazione Italiana Colture Cellulari (ONLUS-AICC) Workshopo nazionale . Meccanismi di farmacoresistenza e radioresistenza delle cellule tumorali Istituto Superiore di Sanità, Roma 6-7 Dicembre 2005 (Roma)
libro: Convegno annuale Associazione Italiana Colture Cellulari (ONLUS-AICC) Workshop Nazionale Farmacoresistenza e radioresistenza delle cellule tumorali - ()

2108/40304 - 2005 - Oral administration of the PARP-1 inhibitor GPI 15427 increases the anti-tumor activity of irinotecan against colon carcinomas
Tentori, Lucio; Graziani, Grazia - 02 - Intervento a convegno
congresso: Annual meeting American Association for cancer research (Anaheim)
libro: Proceedings of the 96th Annual Meeting American Association for Cancer Research - (9789998255296)

2108/40457 - 2005 - N3-methyladenine induces early poly(ADP-ribosylation), reduction of nuclear factor-kappa B DNA binding ability, and nuclear up-regulation of telomerase activity.
Tentori, Lucio; Amici, Carla; Graziani, Grazia - 01 - Articolo su rivista
rivista: MOLECULAR PHARMACOLOGY (American Society for Pharmacology and Experimental Therapeutics:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7024, EMAIL: pstoute@aspet.org, INTERNET: http://www.aspet.org, Fax: (301)634-7099) pp. - - issn: 0026-895X - wos: WOS:000226412900026 (11) - scopus: 2-s2.0-13444282652 (10)

2108/41956 - 2005 - Role of PARP, NF-kB and telomerase in necrosis induced by selective methylation of N3-adenine.
Tentori, Lucio; Muzi, Alessia; Graziani, Grazia - 02 - Intervento a convegno
congresso: XVII Italian Congress on the ADP-ribosylation processes, 17-18 Dicembre 2004, Rome, Italy (Rome, Italy)
libro: XVII Italian Congress on the ADP-ribosylation processes - ()

2108/41960 - 2005 - Oral administration of PARP inhibitor GPI 18180 increases the anti-tumor activity of temozolomide against intracranial melanoma in mice.
Tentori, Lucio; Graziani, Grazia; Muzi, Alessia - 02 - Intervento a convegno
congresso: 41st Annual Meeting American Society of Clinical Oncology (ASCO). 13-17 Maggio 2005 (Orlando, Florida, USA)

2108/41652 - 2005 - Chemopotentiation by PARP inhibitors in cancer therapy
Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: PHARMACOLOGICAL RESEARCH (Attuale:ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 24-28 OVAL RD, LONDON, ENGLAND, NW1 7DX Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 25-33 - issn: 1043-6618 - wos: WOS:000229973300004 (170) - scopus: 2-s2.0-19444375973 (189)

2108/41932 - 2005 - PARP-1 inhibition to treat cancer, ischemia, inflammation
Graziani, Grazia; Battaini, Fiorenzo Maria - 01 - Articolo su rivista
rivista: PHARMACOLOGICAL RESEARCH (Attuale:ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 24-28 OVAL RD, LONDON, ENGLAND, NW1 7DX Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 1-4 - issn: 1043-6618 - wos: WOS:000229973300001 (21) - scopus: 2-s2.0-19444365214 (19)

2108/41650 - 2005 - Generation of an immortalized human endothelial cell line as a model of neovascular proliferating endothelial cells to assess chemosensitivity to anticancer drugs.
Tentori, Lucio; Muzi, Alessia; Vernole, Patrizia; Graziani, Grazia - 01 - Articolo su rivista
rivista: INTERNATIONAL JOURNAL OF ONCOLOGY (National Hellenic Research Foundation:48 Vas Constatinou Avenue, Athens 11635 Greece:011 30 1 7241505, Fax: 011 30 1 7241505Editore attuale:PROFESSOR D A SPANDIDOS, 1, S MERKOURI ST, EDITORIAL OFFICE,, ATHENS, GREECE, 116 35. Editore precedente:Editorial Academy of the International Journal of Oncology.) pp. 525-535 - issn: 1019-6439 - wos: WOS:000230548500028 (28) - scopus: 2-s2.0-33644693775 (27)

2108/41653 - 2005 - Brain distribution and efficacy as chemosensitizer of an oral formulation of PARP-1 inhibitor GPI 15427 in experimental models of CNS tumors.
Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: INTERNATIONAL JOURNAL OF ONCOLOGY (National Hellenic Research Foundation:48 Vas Constatinou Avenue, Athens 11635 Greece:011 30 1 7241505, Fax: 011 30 1 7241505Editore attuale:PROFESSOR D A SPANDIDOS, 1, S MERKOURI ST, EDITORIAL OFFICE,, ATHENS, GREECE, 116 35. Editore precedente:Editorial Academy of the International Journal of Oncology.) pp. 415-422 - issn: 1019-6439 - wos: WOS:000226481500014 (40) - scopus: 2-s2.0-19444386117 (42)

2108/41953 - 2005 - Oral administration of the PARP-1 inhibitor GPI 15427 increases the anti-tumor activity of irinotecan and temozolomide combination against colon carcinoma
Tentori, Lucio; Graziani, Grazia - 02 - Intervento a convegno
congresso: PARP2005: Bench to Bedside (Newcastle upon Tyne (UK))
libro: Medical Science Monitor “PARP2005: Bench to Bedside” Newcastle upon Tyne, Gateshead, UK 5-7 Ottobre 2005. - ()

2108/40973 - 2004 - Primary cultures of microglial cells for testing toxicity of anticancer drugs
Graziani, Grazia; Tentori, Lucio - 01 - Articolo su rivista
rivista: TOXICOLOGY LETTERS (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. 91-94 - issn: 0378-4274 - wos: WOS:000220283700010 (13) - scopus: 2-s2.0-1342285573 (15)

2108/68596 - 2004 - Valproic acid inhibits proliferation and affects androgen sensitivity in prostatic cancer cells.
Graziani, Grazia - 02 - Intervento a convegno
congresso: SEVENTH INTERNATIONAL CONFERENCE OF ANTICANCER RESEARCH ()

2108/68601 - 2004 - Valproic acid inhibits proliferation and affects androgen sensitività in prostatic cancer cells
Graziani, Grazia - 02 - Intervento a convegno
congresso: XIV Congresso Nazionale della Società Italiana di Urologia Oncologica (S.I.Ur.O) (Trieste)

2108/34454 - 2004 - Oral administration of the PARP-1 inhibitor GPI 15427 increases the anti-tumor activity of temozolomide against melanoma growing at the CNS site
Tentori, Lucio; Graziani, Grazia - 02 - Intervento a convegno
congresso: 95th Annual meeting American Association for Cancer Research (AACR), Orlando, Florida, USA. 27-31 Marzo 2004 (Orlando, Florida, USA)
libro: Proceedings of the 95th Annual meeting American Association for Cancer Research (AACR), Orlando, Florida, USA - ()

2108/40447 - 2004 - Temozolomide: An Update on Pharmacological Strategies to Increase its Antitumour Activity
Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: MEDICINAL CHEMISTRY REVIEWS-ONLINE (Bentham Science Publishers, Ltd.) pp. 141-150 - issn: 1567-2034 - wos: (0) - scopus: (0)

2108/34693 - 2004 - Influence of mismatch repair system and p53 on celi cycle perturbation, apoptosis and chromosomal damage induced by bleomycin
Vernole, Patrizia; Graziani, Grazia; Tentori, Lucio - 02 - Intervento a convegno
congresso: ELSO 2004 Meeting 8th International World Congress of Cell (Nizza)

2108/69002 - 2004 - Valproic acid inhibits proliferation and affects androgen sensitivity in prostatic cells
Graziani, Grazia; Sica, Giuseppe - 02 - Intervento a convegno
congresso: 58° Congresso Società Italiana di Anatomia (Chieti)

2108/40437 - 2004 - Is photodecomposition more important than metabolic activation for the antitumor activity of dacarbazine (multiple letters)
Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: MOLECULAR CANCER THERAPEUTICS (Philadelphia, PA : American Association for Cancer Research, c2001-) pp. 383-384 - issn: 1535-7163 - wos: (0) - scopus: 2-s2.0-4444265579 (1)

2108/40451 - 2004 - Primary cultures of microglial cells for testing toxicity of anticancer drugs.
Graziani, Grazia; Tentori, Lucio - 01 - Articolo su rivista
rivista: TOXICOLOGY LETTERS (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. 91-94 - issn: 0378-4274 - wos: WOS:000220283700010 (13) - scopus: 2-s2.0-1342285573 (15)

2108/68609 - 2003 - Systemic administration of the PARP-1 inhibitor GPI 15427 increases the antitumor activity of temozolomide against metastatic melanoma.
Tentori, Lucio; Graziani, Grazia - 02 - Intervento a convegno
congresso: Poly (ADP-ribose) polymerase as novel therapeutic targets - PARP 2003 (Lisbona, Portogallo)

2108/68612 - 2003 - Up-regulation of carcinoembryonic antigen (CEA) expression by staurosporine in circulating colon cancer cells
Formica, Vincenzo; Prete, Salvatore; Graziani, Grazia; Aquino, Angelo - 02 - Intervento a convegno
congresso: 20th International Academy of Tumor Marker Oncology (IATMO) Conference on Tumor markers in cancer diagnosis and therapy ()

2108/68606 - 2003 - Influence of PARP-1 inhibitors on the antitumor activity of methylating agents.
Tentori, Lucio; Graziani, Grazia - 02 - Intervento a convegno
congresso: XVI Italian Congress on THE ADP-RYBOSILATION PROCESSES (Pavia)

2108/68604 - 2003 - Systemic administration of the PARP inhibitor GPI 15427 increases the anti-tumor activity of temozolomide in melanoma, glioma and lymphoma preclinical models in vivo
Tentori, Lucio; Graziani, Grazia - 02 - Intervento a convegno
congresso: 94th meeting AACR (Washington, DC, USA)

2108/68602 - 2003 - Valproic acid increases the stimulatory effects of estrogens on proliferation of human endometrial adenocarcinoma cells
Graziani, Grazia; Tentori, Lucio - 02 - Intervento a convegno
congresso: AUTUMN MEETING OF THE BELGIAN SOCIETY OF FUNDAMENTAL AND CLINICAL PHYSIOLOGY AND PHARMOCOLOGY (Gent, Belgio)

2108/51093 - 2003 - Systemic administration of GPI 15427, a novel Poly(ADP-Ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma
Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: CLINICAL CANCER RESEARCH (American Association of Cancer Research:150 South Independence Mall West, #826:Philadelphia, PA 19106:(215)440-9300, EMAIL: pubs@aacr.org, INTERNET: http://www.aacr.org, Fax: (215)440-7228) pp. 5370-5379 - issn: 1078-0432 - wos: WOS:000186558400041 (187) - scopus: 2-s2.0-10744233684 (205)

2108/52204 - 2003 - Valproic acid increases the stimulatory effect of estrogens on proliferation of human endometrial adenocarcinoma cells
Graziani, Grazia; Tentori, Lucio - 01 - Articolo su rivista
rivista: ENDOCRINOLOGY (Endocrine Society / Maryland:8401 Connecticut Avenue, Suite 900:Chevy Chase, MD 20815:(301)941-0200, (301)941-0200, (301)941-0232, EMAIL: journals@endo-society.org, INTERNET: http://www.endo.society.org, Fax: (301)941-0259) pp. - - issn: 0013-7227 - wos: WOS:000183547800011 (22) - scopus: 2-s2.0-0038675351 (25)

2108/51094 - 2003 - Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (ADP-ribose) polymerase inhibitor
Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: MOLECULAR PHARMACOLOGY (American Society for Pharmacology and Experimental Therapeutics:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7024, EMAIL: pstoute@aspet.org, INTERNET: http://www.aspet.org, Fax: (301)634-7099) pp. 192-202 - issn: 0026-895X - wos: WOS:000179868900023 (42) - scopus: 2-s2.0-0037220314 (45)

2108/65859 - 2002 - Stem cell factor activates telomerase in mouse mitotic spermatogonia and in primordial germ cells
Dolci, Susanna; Faraoni, Isabella; Graziani, Grazia; Geremia, Raffaele - 01 - Articolo su rivista
rivista: JOURNAL OF CELL SCIENCE (The Company of Biologists Limited:Bidder Building, 140 Cowley Road, Cambridge CB4 0DL United Kingdom:011 44 1223 420482, EMAIL: mandy@thecob.demon.co.uk, INTERNET: http://www.biologists.com, Fax: 011 44 1223 423353) pp. 1643-1649 - issn: 0021-9533 - wos: WOS:000175479800010 (19) - scopus: 2-s2.0-0037093043 (26)

2108/52888 - 2002 - Potential clinical applications of poly(ADP-ribose) polymerase (PARP) inhibitors
Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: PHARMACOLOGICAL RESEARCH (Attuale:ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 24-28 OVAL RD, LONDON, ENGLAND, NW1 7DX Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 73-85 - issn: 1043-6618 - wos: WOS:000174516100001 (137) - scopus: 2-s2.0-0036447366 (146)

2108/51748 - 2002 - Treatment of peripheral blood with staurosporine increases detection of circulating carcinoembryonic antigen positive tumor cells
Aquino, Angelo; Prete, Salvatore; Formica, Vincenzo; Graziani, Grazia - 01 - Articolo su rivista
rivista: INTERNATIONAL JOURNAL OF CANCER (Hoboken N.J.: Wiley New York NY: Wiley-Liss) pp. 119-121 - issn: 0020-7136 - wos: WOS:000176008300020 (7) - scopus: 2-s2.0-0036643851 (7)

2108/52206 - 2002 - CRH inhibits cell growth of human endometrial adenocarcinoma cells via CRH-receptor 1-mediated activation of cAMP-PKA pathway
Graziani, Grazia; Tentori, Lucio - 01 - Articolo su rivista
rivista: ENDOCRINOLOGY (Endocrine Society / Maryland:8401 Connecticut Avenue, Suite 900:Chevy Chase, MD 20815:(301)941-0200, (301)941-0200, (301)941-0232, EMAIL: journals@endo-society.org, INTERNET: http://www.endo.society.org, Fax: (301)941-0259) pp. 807-813 - issn: 0013-7227 - wos: WOS:000174034800010 (66) - scopus: 2-s2.0-0036170522 (66)

2108/51741 - 2002 - A novel method for monitoring response to chemotherapy based on the detection of circulating cancer cells: a case report
Aquino, Angelo; Prete, Salvatore; Formica, Vincenzo; Torino, Francesco; Graziani, Grazia - 01 - Articolo su rivista
rivista: JOURNAL OF CHEMOTHERAPY (ESIFT Srl:Casella Postale 147, I 50018 Scandicci Fi Italy:011 39 055 4271516, EMAIL: mary@jchemother.it, Fax: 011 39 055 4271280) pp. 412-416 - issn: 1120-009X - wos: WOS:000178024700015 (10) - scopus: 2-s2.0-0036693979 (12)

2108/52889 - 2002 - Pharmacological strategies to increase the antitumor activity of methylating agents
Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: CURRENT MEDICINAL CHEMISTRY (Bentham Science Publishers BV:PO Box 7917, Exec Ste Y 26, Saif Zone Sharjah Uae:011 971 6 5571132, EMAIL: benthams@emirates.net.ae, INTERNET: http://www.bentham.org, Fax: 011 971 6 5571134) pp. 1285-1301 - issn: 0929-8673 - wos: WOS:000176238400003 (53) - scopus: 2-s2.0-0036287678 (53)

2108/51746 - 2002 - Treatment of peripheral blood with staurosporine increases detection of circulating carcinoembryonic antigen positive tumor cells
Aquino, Angelo; Prete, Salvatore; Formica, Vincenzo; Graziani, Grazia - 01 - Articolo su rivista
rivista: INTERNATIONAL JOURNAL OF CANCER (Hoboken N.J.: Wiley New York NY: Wiley-Liss) pp. 119-121 - issn: 0020-7136 - wos: WOS:000176008300020 (7) - scopus: 2-s2.0-0036643851 (7)

2108/49441 - 2002 - Stem cell factor activates telomerase in mouse mitotic spermatogonia and in primordial germ cells
Dolci, Susanna; Faraoni, Isabella; Graziani, Grazia - 01 - Articolo su rivista
rivista: JOURNAL OF CELL SCIENCE (The Company of Biologists Limited:Bidder Building, 140 Cowley Road, Cambridge CB4 0DL United Kingdom:011 44 1223 420482, EMAIL: mandy@thecob.demon.co.uk, INTERNET: http://www.biologists.com, Fax: 011 44 1223 423353) pp. 1643-1649 - issn: 0021-9533 - wos: WOS:000175479800010 (19) - scopus: 2-s2.0-0037093043 (26)

2108/52890 - 2002 - Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site
Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: BLOOD (New York: Elsevier Inc. [Washington DC etc.]: American Society of Hematology) pp. 2241-2244 - issn: 0006-4971 - wos: WOS:000174355800051 (80) - scopus: 2-s2.0-0037085761 (87)

2108/52891 - 2002 - Apoptotic and genotoxic effects of a methyl sulfonate ester that selectively generates N3-methyladenine and poly(ADP-ribose) polymerase inhibitors in normal peripheral blood lymphocytes
Tentori, Lucio; Vernole, Patrizia; Graziani, Grazia - 01 - Articolo su rivista
rivista: CANCER CHEMOTHERAPY AND PHARMACOLOGY (Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229) pp. 217-224 - issn: 0344-5704 - wos: WOS:000174863200006 (14) - scopus: 2-s2.0-0036189995 (15)

2108/52883 - 2002 - Poly(ADP-ribose) polymerase inhibitor increases growth inhibition and reduces G2/M cell accumulation induced by temozolomide in malignant glioma cells
Tentori, Lucio; Torino, Francesco; Graziani, Grazia - 01 - Articolo su rivista
rivista: GLIA (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 44-54 - issn: 0894-1491 - wos: WOS:000178364300004 (59) - scopus: 2-s2.0-0036793612 (69)

2108/51743 - 2002 - Pharmacological modulation of carcinoembryonic antigen in human cancer cells: studies with staurosporine
Prete, Salvatore; De Vecchis, Liana; Graziani, Grazia; Aquino, Angelo - 01 - Articolo su rivista
rivista: INTERNATIONAL IMMUNOPHARMACOLOGY (Tokyo ; Oxford ; New York ; London ; Amsterdam ; Shannon ; Paris : Eldevier : Elsevier) pp. 641-651 - issn: 1567-5769 - wos: WOS:000175179200003 (7) - scopus: 2-s2.0-18344392256 (8)

2108/52191 - 2001 - Influence of Mycobacterium bovis bacillus Calmette Guérin on in vitro induction of CD1 molecules in human adherent mononuclear cells
Prete, Salvatore; Graziani, Grazia; Aquino, Angelo - 01 - Articolo su rivista
rivista: INFECTION AND IMMUNITY ([Washington, etc.] American Society for Microbiology.) pp. 7461-7470 - issn: 0019-9567 - wos: WOS:000172297600034 (22) - scopus: 2-s2.0-0035178073 (22)

2108/52882 - 2001 - Effects of single or split exposure of leukemic cells to temozolomide, combined with poly(ADP-ribose) polymerase inhibitors on cell growth, chromosomal aberrations and base excision repair components
Tentori, Lucio; Vernole, Patrizia; De Fabritiis, Paolo; Graziani, Grazia - 01 - Articolo su rivista
rivista: CANCER CHEMOTHERAPY AND PHARMACOLOGY (Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229) pp. 361-369 - issn: 0344-5704 - wos: WOS:000168384000011 (28) - scopus: 2-s2.0-0034743378 (33)

2108/52887 - 2001 - Poly (ADP-ribose) polymerase inhibitor increases apoptosis and reduces necrosis induced by a DNA minor groove binding methyl sulfonate ester
Tentori, Lucio; Vernole, Patrizia; Graziani, Grazia - 01 - Articolo su rivista
rivista: CELL DEATH AND DIFFERENTIATION (Nature Publishing Group:Brunel Road Houndmills, Basingstoke RG21 6XS United Kingdom:011 44 20 78334000, EMAIL: institutions@natureny.com, INTERNET: http://www.nature.com, Fax: 011 44 20 78434640) pp. 817-828 - issn: 1350-9047 - wos: WOS:000169999500007 (37) - scopus: 2-s2.0-0034897316 (41)

2108/52877 - 2001 - Combined effects of adenovirus-mediated wild-type p53 transduction, temozolomide and poly (ADP-ribose) polymerase inhibitor in mismatch repair deficient and non-proliferating tumor cells
Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: CELL DEATH AND DIFFERENTIATION (Nature Publishing Group:Brunel Road Houndmills, Basingstoke RG21 6XS United Kingdom:011 44 20 78334000, EMAIL: institutions@natureny.com, INTERNET: http://www.nature.com, Fax: 011 44 20 78434640) pp. 457-469 - issn: 1350-9047 - wos: WOS:000168534800003 (33) - scopus: 2-s2.0-0035009692 (31)

2108/67994 - 2001 - Bacillus Calmette-Guerin down-regulates CD1b induction by granulocyte-macrophage colony stimulating factor in human peripheral blood monocytes
Franzese, Ornella; Graziani, Grazia - 01 - Articolo su rivista
rivista: JOURNAL OF CHEMOTHERAPY (ESIFT Srl:Casella Postale 147, I 50018 Scandicci Fi Italy:011 39 055 4271516, EMAIL: mary@jchemother.it, Fax: 011 39 055 4271280) pp. 52-58 - issn: 1120-009X - wos: WOS:000167116700008 (8) - scopus: 2-s2.0-0035117685 (9)

2108/22749 - 2001 - hMSH3 overexpression and cellular response to cytotoxic anticancer agents
Graziani, Grazia; Vernole, Patrizia - 01 - Articolo su rivista
rivista: CARCINOGENESIS (Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485) pp. 1131-1137 - issn: 0143-3334 - wos: WOS:000170471800003 (12) - scopus: 2-s2.0-0034903747 (12)

2108/67996 - 2000 - Clinical applications of telomerase in cancer treatment
Faraoni, Isabella; Graziani, Grazia - 01 - Articolo su rivista
rivista: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy () pp. 161-170 - issn: - wos: WOS:000088509700006 (7) - scopus: 2-s2.0-0033852802 (8)

2108/67997 - 2000 - Telomerase as a potential anticancer target: growth inhibition and genomic instability
Faraoni, Isabella; Graziani, Grazia - 01 - Articolo su rivista
rivista: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy () pp. 3-6 - issn: - wos: WOS:000086635200002 (1) - scopus: 2-s2.0-0034144407 (1)

2108/51758 - 2000 - Effect of 5-fluorouracil on carcinoembryonic antigen expression and shedding at clonal level in colon cancer cells
Aquino, Angelo; Prete, Salvatore; Graziani, Grazia - 01 - Articolo su rivista
rivista: ANTICANCER RESEARCH (Kapandriti: International Institute of Anticancer Research, 1995 Earliest publisher: Καπανδρίτι: Ιωάννης Γ. Δεληνάσιος, 1981-1995 Kapandriti: Iōannīs G. Delīnasios, 1981-1995) pp. 3475-3484 - issn: 0250-7005 - wos: WOS:000165634100017 (20) - scopus: 2-s2.0-0033637480 (23)

2108/51720 - 2000 - Staurosporine increases carcinoembryonic antigen expression in a human colon cancer cell line
Aquino, Angelo; Prete, Salvatore; De Vecchis, Liana; Graziani, Grazia - 01 - Articolo su rivista
rivista: JOURNAL OF CHEMOTHERAPY (ESIFT Srl:Casella Postale 147, I 50018 Scandicci Fi Italy:011 39 055 4271516, EMAIL: mary@jchemother.it, Fax: 011 39 055 4271280) pp. 167-172 - issn: 1120-009X - wos: WOS:000086588300009 (11) - scopus: 2-s2.0-0034009702 (9)

2108/68651 - 2000 - Apoptotic and clastogenic effects of methylating agents, alone or combined with poly(ADP-ribose) polymerase inhibitor, in peripheral blood lymphocytes
Tentori, Lucio; Graziani, Grazia - 02 - Intervento a convegno
congresso: Immunopharmacology and Immunotherapy Today Congress (Firenze)

2108/68616 - 2000 - 5-Fluorouracil increases carcinoembryonic antigen expression and shedding in colon cancer cell clones with different basal levels of the molecule
Aquino, Angelo; Prete, Salvatore; Graziani, Grazia - 02 - Intervento a convegno
congresso: Immunopharmacology and Immunotherapy Today Congress (Firenze)

2108/52886 - 2000 - Cytotoxic and clastogenic effects of a DNA minor groove binding methyl sulfonate ester in mismatch repair deficient leukemic cells
Tentori, Lucio; Vernole, Patrizia; Turriziani, Mario; Graziani, Grazia - 01 - Articolo su rivista
rivista: LEUKEMIA (-, LONDON, ENGLAND: NATURE PUBLISHING GROUP, -London,United Kingdom: Macmillan Magazines Limited -[Baltimore, Md.] : Williams & Wilkins, [c1987]-) pp. 1451-1459 - issn: 0887-6924 - wos: WOS:000088572500018 (22) - scopus: 2-s2.0-0033880685 (23)

2108/68639 - 2000 - Effect of staurosporine on carcinoembryonic antigen expression and shedding in human cancer cells.
Prete, Salvatore; Graziani, Grazia; Aquino, Angelo - 02 - Intervento a convegno
congresso: Immunopharmacology and Immunotherapy Today Congress (Firenze)

2108/68718 - 2000 - Chemoresistance pattern of HL-60R cells overexpressing the hMSH3 protein.
Graziani, Grazia - 02 - Intervento a convegno
congresso: 5th International Symposium on Predictive Oncology and Therapy. (Ginevra, Svizzera)

2108/68672 - 2000 - Soluble factor(s) are responsible for the influence of BCG on CD1b induction by GM-CSF: studies with recombinant BCG carrying the GFP gene.
Prete, Salvatore; Graziani, Grazia - 02 - Intervento a convegno
congresso: Immunopharmacology and Immunotherapy Today Congress (Firenze)

2108/68687 - 2000 - Limited induction of CD1b expression by BCG in human adherent mononuclear cells is mediated by GM-CSF
Prete, Salvatore; Graziani, Grazia - 02 - Intervento a convegno
congresso: Immunopharmacology and Immunotherapy Today Congress (Firenze)

2108/68686 - 2000 - Influence of bacillus calmette-guerin (BCG) on induction of antigen-presenting cd1b molecule by granulocyte- macrophage colony stimulating factor (GM-CSF).
Prete, Salvatore; Aquino, Angelo; Graziani, Grazia - 02 - Intervento a convegno
congresso: Immunopharmacology and Immunotherapy Today Congress (Firenze)

2108/67967 - 2000 - Attenuation of O(6)-methylguanine-DNA methyltransferase activity and mRNA levels by cisplatin and temozolomide in jurkat cells
Graziani, Grazia; Faraoni, Isabella - 01 - Articolo su rivista
rivista: THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (Baltimore: Williams & Wilkins Bethesda, MD; American Society for Pharmacology and Experimental Therapeutics) pp. 664-671 - issn: 0022-3565 - wos: WOS:000088266000035 (54) - scopus: 2-s2.0-0033943310 (51)

2108/52885 - 1999 - Treatment with temozolomide and poly(ADP-ribose) polymerase inhibitors induces early apoptosis and increases base excision repair gene transcripts in leukemic cells resistant to triazene compounds
Tentori, Lucio; Turriziani, Mario; Graziani, Grazia - 01 - Articolo su rivista
rivista: LEUKEMIA (-, LONDON, ENGLAND: NATURE PUBLISHING GROUP, -London,United Kingdom: Macmillan Magazines Limited -[Baltimore, Md.] : Williams & Wilkins, [c1987]-) pp. 901-909 - issn: 0887-6924 - wos: WOS:000080840100012 (48) - scopus: 2-s2.0-0032587580 (55)

2108/67998 - 1999 - Suppression of telomerase activity as an indicator of drug-induced cytotoxicity against cancer cells: in vitro studies with fresh human tumor samples
Faraoni, Isabella; Graziani, Grazia; Turriziani, Mario - 01 - Articolo su rivista
rivista: LABORATORY INVESTIGATION (Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320) pp. 993-1005 - issn: 0023-6837 - wos: WOS:000082110200009 (24) - scopus: 2-s2.0-0032774738 (29)

2108/67999 - 1999 - In vitro infection of CD4+ T lymphocytes with HTLV-I generates immortalized cell lines coexpressing lymphoid and myeloid cell markers
Macchi, Beatrice; Graziani, Grazia - 01 - Articolo su rivista
rivista: LEUKEMIA (-, LONDON, ENGLAND: NATURE PUBLISHING GROUP, -London,United Kingdom: Macmillan Magazines Limited -[Baltimore, Md.] : Williams & Wilkins, [c1987]-) pp. 222-229 - issn: 0887-6924 - wos: WOS:000078759000012 (8) - scopus: 2-s2.0-0033000578 (7)

2108/68000 - 1998 - Adjuvant treatment of breast cancer: a pilot immunochemotherapy study with CMF, interleukin-2 and interferon alpha
Turriziani, Mario; Graziani, Grazia; De Vecchis, Liana - 01 - Articolo su rivista
rivista: CANCER IMMUNOLOGY, IMMUNOTHERAPY (Heidelberg; Berlin: Springer) pp. 157-166 - issn: 0340-7004 - wos: WOS:000076895300005 (10) - scopus: 2-s2.0-0031770891 (10)

2108/52881 - 1998 - Role of wild-type p53 on the antineoplastic activity of temozolomide alone or combined with inhibitors of poly(ADP-Ribose) polymerase
Tentori, Lucio; Faraoni, Isabella; Graziani, Grazia - 01 - Articolo su rivista
rivista: THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (Baltimore: Williams & Wilkins Bethesda, MD; American Society for Pharmacology and Experimental Therapeutics) pp. 884-893 - issn: 0022-3565 - wos: WOS:000073585000066 (30) - scopus: 2-s2.0-0031863682 (29)

2108/52925 - 1998 - Involvement of the mismatch repair system in temozolomide-induced apoptosis
Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: MOLECULAR PHARMACOLOGY (American Society for Pharmacology and Experimental Therapeutics:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7024, EMAIL: pstoute@aspet.org, INTERNET: http://www.aspet.org, Fax: (301)634-7099) pp. 334-341 - issn: 0026-895X - wos: WOS:000075249300013 (253) - scopus: 2-s2.0-0031848832 (258)

2108/52880 - 1998 - Rifampin increases cytokine-induced expression of the CD1b molecule in human peripheral blood monocytes
Tentori, Lucio; Graziani, Grazia; Aquino, Angelo - 01 - Articolo su rivista
rivista: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (American Society for Microbiology:PO Box 11127:Birmingham, AL 35201:(800)633-4931, (205)995-1567, EMAIL: asm.nonmembers.subs@ebsco.com, INTERNET: http://www.asm.org, Fax: (205)995-1588) pp. 550-554 - issn: 0066-4804 - wos: WOS:000072311000011 (25) - scopus: 2-s2.0-0031894346 (29)

2108/22750 - 1998 - Mutation of the mismatch repair gene hMSH2 and hMSH6 in a human T-cell leukemia line tolerant to methylating agents
Vernole, Patrizia; Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: GENES, CHROMOSOMES & CANCER (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 159-166 - issn: 1045-2257 - wos: WOS:000075635000009 (46) - scopus: 2-s2.0-0031668272 (47)

2108/68720 - 1998 - Influenza di farmaci antivirali o antimicobatterici sulla proliferazione di monociti umani e sulla espressione del CD1b. Secondo Progetto di ricerca Tubercolosi
Tentori, Lucio; Graziani, Grazia; Aquino, Angelo - 02 - Intervento a convegno
congresso: Progress Report II progetto di ricerca Tubercolosi (Roma)

2108/52884 - 1998 - Effect of rifampin on CD1b expression and double-negative T cell responses against mycobacteria-derived glycolipid antigen
Tentori, Lucio; Graziani, Grazia; Aquino, Angelo - 01 - Articolo su rivista
rivista: LIFE SCIENCES (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 985-994 - issn: 0024-3205 - wos: WOS:000075484700001 (7) - scopus: 2-s2.0-0032516533 (9)

2108/68634 - 1998 - New aspects of immune responses against mycobacteria: immunopharmacology studies
Aquino, Angelo; Tentori, Lucio; Prete, Salvatore; Graziani, Grazia - 01 - Articolo su rivista
rivista: HAEMATOLOGICA (Fondaz Ferrata Storti:Strada Nuova 134, 27100 Pavia Italy:011 39 0382 531182, EMAIL: office@haematologica.it, Fax: 011 39 0382 27721) pp. 58-60 - issn: 0390-6078 - wos: (0) - scopus: (0)

2108/68001 - 1998 - Effect of prostaglandin A1 on proliferation and telomerase activity of human melanoma cells in vitro
Franzese, Ornella; Graziani, Grazia - 01 - Articolo su rivista
rivista: MELANOMA RESEARCH (Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320) pp. 323-328 - issn: 0960-8931 - wos: WOS:000076080700005 (9) - scopus: 2-s2.0-0031593738 (12)

2108/68851 - 1998 - Decline in telomerase activity as a measure of tumor cell killing by antineoplastic agents in vitro
Faraoni, Isabella; Turriziani, Mario; De Vecchis, Liana; Graziani, Grazia - 03 - Contributo in libro
libro: The year book of oncology 1998 - (0815197101)

2108/50284 - 1998 - Mutation of the mismatch repair gene hMSH2 and hMSH6 in a human T-cell leukemia line tolerant to methylating agents
Vernole, Patrizia; Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: GENES, CHROMOSOMES & CANCER (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 159-166 - issn: 1045-2257 - wos: WOS:000075635000009 (46) - scopus: 2-s2.0-0031668272 (47)

2108/52720 - 1998 - Effect of the combined treatment with 5-fluorouracil, gamma-interferon or folinic acid on carcinoembryonic antigen expression in colon cancer cells
Aquino, Angelo; Prete, Salvatore; Graziani, Grazia; Turriziani, Mario; De Vecchis, Liana - 01 - Articolo su rivista
rivista: CLINICAL CANCER RESEARCH (American Association of Cancer Research:150 South Independence Mall West, #826:Philadelphia, PA 19106:(215)440-9300, EMAIL: pubs@aacr.org, INTERNET: http://www.aacr.org, Fax: (215)440-7228) pp. 2473-2481 - issn: 1078-0432 - wos: WOS:000076366700024 (38) - scopus: (0)

2108/69003 - 1997 - In vitro measurement of ovarian cancer cells chemosensitivity to antineoplastic drugs as inhibition of telomerase activity
Faraoni, Isabella; Turriziani, Mario; Graziani, Grazia - 02 - Intervento a convegno
congresso: First Joint International Conference Gene targets for cancer treatment ()

2108/68721 - 1997 - Influenza di farmaci antivirali o antimicobatterici sulla proliferazione di monociti umani e sulla espressione del CD1b
Tentori, Lucio; Aquino, Angelo; Graziani, Grazia - 02 - Intervento a convegno
congresso: Progress report primo Progetto Ricerca Tubercolosi (Roma)

2108/68722 - 1997 - Role of mismatch repair in apoptosis induced by methyltriazenes.
Graziani, Grazia; Tentori, Lucio - 02 - Intervento a convegno
congresso: Eighty-eighth annual meeting of the American Association for Cancer Research (AACR) (San Diego, CA, USA)

2108/52878 - 1997 - Dacarbazine-induced immunogenicity of a murine leukemia is attenuated in cells transfected with mutated K-ras gene
Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (Attuale:APSIT ASSOC PROM STUD IMMUNOL TUMOR, VIALE REGINA ELENA 291, ROME, ITALY, 00161 Centro Ricerca Sperimentale:Via Delle Messi d Oro 156, 00158 Rome Italy:011 39 06 52662536, EMAIL: journal@ifo.it, INTERNET: http://crs.ifo.it, Fax: 011 39 06 52662505) pp. 15-22 - issn: 0392-9078 - wos: WOS:A1997WX28100003 (17) - scopus: 2-s2.0-12644289322 (18)

2108/52876 - 1997 - Cytokine-induced expression of CD1b molecules by peripheral blood monocytes: Influence of 3'-azido-3'-deoxythymidine
Tentori, Lucio; Aquino, Angelo; Graziani, Grazia - 01 - Articolo su rivista
rivista: PHARMACOLOGICAL RESEARCH (Attuale:ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 24-28 OVAL RD, LONDON, ENGLAND, NW1 7DX Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 135-140 - issn: 1043-6618 - wos: WOS:A1997WZ95100011 (10) - scopus: 2-s2.0-18744420729 (8)

2108/52926 - 1997 - Cytokine-induced expression of CD1b molecules by peripheral blood monocytes: influence of 3'-azido-3'-deoxythymidine
Tentori, Lucio; Aquino, Angelo; Graziani, Grazia - 01 - Articolo su rivista
rivista: PHARMACOLOGICAL RESEARCH (Attuale:ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 24-28 OVAL RD, LONDON, ENGLAND, NW1 7DX Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 135-140 - issn: 1043-6618 - wos: WOS:A1997WZ95100011 (10) - scopus: 2-s2.0-18744420729 (8)

2108/68003 - 1997 - CD1b expression in Molt-4 clones exposed to IL-4 and GM-CSF
Graziani, Grazia; Franzese, Ornella - 01 - Articolo su rivista
rivista: EUROPEAN JOURNAL OF HISTOCHEMISTRY (Tipolitografia l Ponzio:Viale Montegrappa 2, I 27100 Pavia Italy:011 39 0382 576600, Fax: 011 39 0382 574200) pp. 119-120 - issn: 1121-760X - wos: WOS:A1997YC11600055 (1) - scopus: 2-s2.0-0031293159 (1)

2108/68005 - 1997 - Decline in telomerase activity as a measure of tumor cell killing by antineoplastic agents in vitro
Faraoni, Isabella; Turriziani, Mario; De Vecchis, Liana; Graziani, Grazia - 01 - Articolo su rivista
rivista: CLINICAL CANCER RESEARCH (American Association of Cancer Research:150 South Independence Mall West, #826:Philadelphia, PA 19106:(215)440-9300, EMAIL: pubs@aacr.org, INTERNET: http://www.aacr.org, Fax: (215)440-7228) pp. 579-585 - issn: 1078-0432 - wos: WOS:A1997WY36900013 (74) - scopus: 2-s2.0-0030973269 (75)

2108/52879 - 1997 - Inhibition of O-6-alkylguanine DNA-alkyltransferase or poly(ADP-ribose) polymerase increases susceptibility of leukemic coils to apoptosis induced by temozolomide
Tentori, Lucio; Faraoni, Isabella; Graziani, Grazia - 01 - Articolo su rivista
rivista: MOLECULAR PHARMACOLOGY (American Society for Pharmacology and Experimental Therapeutics:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7024, EMAIL: pstoute@aspet.org, INTERNET: http://www.aspet.org, Fax: (301)634-7099) pp. 249-258 - issn: 0026-895X - wos: WOS:A1997XQ98400009 (59) - scopus: (0)

2108/68016 - 1996 - Development of a novel in vitro chemosensitivity assay: telomerase as a possible marker of tumor cell survival
Faraoni, Isabella; Turriziani, Mario; De Vecchis, Liana; Graziani, Grazia - 01 - Articolo su rivista
rivista: JOURNAL OF CHEMOTHERAPY (ESIFT Srl:Casella Postale 147, I 50018 Scandicci Fi Italy:011 39 055 4271516, EMAIL: mary@jchemother.it, Fax: 011 39 055 4271280) pp. 394-398 - issn: 1120-009X - wos: WOS:A1996VP76500010 (8) - scopus: 2-s2.0-0029903858 (8)

2108/68027 - 1996 - In vitro inactivation of human O6-alkylguanine DNA alkyltransferase by antitumor triazene compounds
Graziani, Grazia - 01 - Articolo su rivista
rivista: THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (Baltimore: Williams & Wilkins Bethesda, MD; American Society for Pharmacology and Experimental Therapeutics) pp. 416-422 - issn: 0022-3565 - wos: WOS:A1996VL70100055 (19) - scopus: 2-s2.0-0030433662 (20)

2108/52721 - 1996 - Drug-induced changes of carcinoembryonic antigen expression in human cancer cells: Effect of 5-fluorouracil
Prete, Salvatore; Aquino, Angelo; De Vecchis, Liana; Graziani, Grazia - 01 - Articolo su rivista
rivista: THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (Baltimore: Williams & Wilkins Bethesda, MD; American Society for Pharmacology and Experimental Therapeutics) pp. 1574-1581 - issn: 0022-3565 - wos: WOS:A1996VY20700061 (18) - scopus: 2-s2.0-12644282546 (20)

2108/68015 - 1996 - Telomerase as a marker of tumor cell viability: A new approach for in vitro chemosensitivity assays?
Faraoni, Isabella; Turriziani, Mario; Graziani, Grazia - 01 - Articolo su rivista
rivista: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (Attuale:APSIT ASSOC PROM STUD IMMUNOL TUMOR, VIALE REGINA ELENA 291, ROME, ITALY, 00161 Centro Ricerca Sperimentale:Via Delle Messi d Oro 156, 00158 Rome Italy:011 39 06 52662536, EMAIL: journal@ifo.it, INTERNET: http://crs.ifo.it, Fax: 011 39 06 52662505) pp. 311-312 - issn: 0392-9078 - wos: WOS:A1996VN98700017 (3) - scopus: 2-s2.0-0029954526 (3)

2108/68723 - 1996 - Inhibition of DNA repair enzyme potentiates apoptosis induced by temozolomide
Graziani, Grazia; Tentori, Lucio - 02 - Intervento a convegno
congresso: Third International Symposium on Impact of Cancer Biotechnology on predictive Oncology & Therapy (Nizza, Francia)

2108/68725 - 1996 - Inhibition of O6-alkylguanine-DNA alkyltransferase increases cytotoxic and apoptotic effects induced by triazenes in leukemic cells.
Graziani, Grazia; Aquino, Angelo; Tentori, Lucio - 02 - Intervento a convegno
congresso: Eighty-seventh annual meeting of AACR (Washington, DC, USA)

2108/373163 - 1996 - In vitro chemosensitivity of neoplastic cells: Telomerase as a possible marker of tumor cell survival
Faraoni, Isabella; Turriziani, Mario; De Vecchis, Liana; Laurenza, Lucia Maria; Graziani, Grazia - 01 - Articolo su rivista
rivista: CHRONICA DERMATOLOGICA (Chronica Dermatologica:Via Monti di Creta 104, 00167 Rome Italy:011 39 6 9126212) pp. 161-168 - issn: 0011-1759 - wos: (0) - scopus: 2-s2.0-0030512761 (1)

2108/51176 - 1995 - In vitro infection of leukemic bone marrow with HTLV-I generates immortalized cell lines expressing T or myeloid cell phenotype
Vernole, Patrizia; Del Poeta, Giovanni; Faraoni, Isabella; Graziani, Grazia - 01 - Articolo su rivista
rivista: LEUKEMIA (-, LONDON, ENGLAND: NATURE PUBLISHING GROUP, -London,United Kingdom: Macmillan Magazines Limited -[Baltimore, Md.] : Williams & Wilkins, [c1987]-) pp. 2071-2081 - issn: 0887-6924 - wos: WOS:A1995TQ15400014 (3) - scopus: 2-s2.0-0029587214 (3)

2108/68727 - 1995 - Characteristics of the infection of rat astroglia and macrophages by HTLV-I.
Macchi, Beatrice; Graziani, Grazia - 02 - Intervento a convegno
congresso: European Brain Bank Network and XXXI Congress of Italian Association of Neuropathology (Pavia)

2108/68028 - 1995 - O6-alkylguanine-DNA alkyltransferase attenuates triazene-induced cytotoxicity and tumor cell immunogenicity in murine L1210 leukemia
Graziani, Grazia; Faraoni, Isabella - 01 - Articolo su rivista
rivista: CANCER RESEARCH (American Association of Cancer Research:150 South Independence Mall West, #826:Philadelphia, PA 19106:(215)440-9300, EMAIL: pubs@aacr.org, INTERNET: http://www.aacr.org, Fax: (215)440-7228) pp. 6231-6236 - issn: 0008-5472 - wos: WOS:A1995TK21100041 (29) - scopus: 2-s2.0-0028971962 (30)

2108/68726 - 1995 - Immunopharmacology of antitumor agents.
Graziani, Grazia; Aquino, Angelo; Tentori, Lucio - 02 - Intervento a convegno
congresso: First European Congress of Pharmacology (Milano)

2108/68029 - 1995 - Chimeric molecules between keratinocyte growth factor and basic fibroblast growth factor define domains that confer receptor binding specificities
Graziani, Grazia - 01 - Articolo su rivista
rivista: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 29813-29818 - issn: 0021-9258 - wos: WOS:A1995TK38000035 (37) - scopus: 2-s2.0-0029610777 (36)

2108/68031 - 1995 - Cisplatin increases sensitivity of human leukemic blasts to triazene compounds
Franchi, Annibale; Graziani, Grazia - 01 - Articolo su rivista
rivista: JOURNAL OF CHEMOTHERAPY (ESIFT Srl:Casella Postale 147, I 50018 Scandicci Fi Italy:011 39 055 4271516, EMAIL: mary@jchemother.it, Fax: 011 39 055 4271280) pp. 224-229 - issn: 1120-009X - wos: WOS:A1995RF34300012 (35) - scopus: 2-s2.0-0029017802 (36)

2108/52875 - 1995 - Triazene compounds induce apoptosis in O6-alkylguanine-DNA alkyltransferase deficient leukemia cell lines
Tentori, Lucio; Graziani, Grazia - 01 - Articolo su rivista
rivista: LEUKEMIA (-, LONDON, ENGLAND: NATURE PUBLISHING GROUP, -London,United Kingdom: Macmillan Magazines Limited -[Baltimore, Md.] : Williams & Wilkins, [c1987]-) pp. 1888-1895 - issn: 0887-6924 - wos: WOS:A1995TG56200016 (47) - scopus: 2-s2.0-0028817014 (50)

2108/52725 - 1993 - In vitro combined effects of human interferons and interleukin-2 on natural cell-mediated cytotoxicity
Aquino, Angelo; Graziani, Grazia - 01 - Articolo su rivista
rivista: INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 1-10 - issn: 0192-0561 - wos: WOS:A1993KH08700001 (4) - scopus: 2-s2.0-0027529665 (4)

2108/68033 - 1993 - Transient HTLV-I infection of a human glioma cell line following cell-free exposure
Graziani, Grazia; Faraoni, Isabella; Macchi, Beatrice - 01 - Articolo su rivista
rivista: VIROLOGY (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 767-769 - issn: 0042-6822 - wos: WOS:A1993MH09200029 (7) - scopus: 2-s2.0-0027364568 (7)

2108/49570 - 1993 - Emergence of double-positive CD4/CD8 cells from adult peripheral blood mononuclear cells infected with human T cell leukemia virus type I (HTLV-I)
Macchi, Beatrice; Graziani, Grazia - 01 - Articolo su rivista
rivista: CELLULAR IMMUNOLOGY (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 376-389 - issn: 0008-8749 - wos: WOS:A1993LM26100014 (35) - scopus: 2-s2.0-0027321768 (35)

2108/68034 - 1992 - Induction of Xenopus oocyte meiotic maturation by the dbl oncogene product
Graziani, Grazia - 01 - Articolo su rivista
rivista: ONCOGENE (Macmillan Magazines Limited:Porters South Crinian Street, London N1 9XW United Kingdom:011 44 207 8334000, 011 44 171 8434982, Fax: 011 44 207 812358) pp. 229-235 - issn: 0950-9232 - wos: WOS:A1992HG98200004 (6) - scopus: 2-s2.0-0026554276 (7)

2108/68037 - 1991 - Alternative splicing generates at least five different isoforms of the human basic-FGF receptor
Graziani, Grazia - 01 - Articolo su rivista
rivista: ONCOGENE (Macmillan Magazines Limited:Porters South Crinian Street, London N1 9XW United Kingdom:011 44 207 8334000, 011 44 171 8434982, Fax: 011 44 207 812358) pp. 1195-1202 - issn: 0950-9232 - wos: WOS:A1991GV26000015 (119) - scopus: 2-s2.0-0025838084 (115)

2108/68039 - 1991 - A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr
Graziani, Grazia - 01 - Articolo su rivista
rivista: THE NEW BIOLOGIST (W B Saunders Company:Fulfillment Department, The Curtis Center, Independence Square West:Philadelphia, PA 19106:(800)654-2452, (215)238-7800, EMAIL: wbspcs@harcourt.com, INTERNET: http://elsevierhealth.com, Fax: (215)238-6445) pp. 372-379 - issn: 1043-4674 - wos: WOS:A1991GK71900010 (161) - scopus: 2-s2.0-0025758833 (166)

2108/68040 - 1991 - Expression of the human dbl-oncogene and proto-oncogene products in insect cells using a baculovirus vector
Graziani, Grazia - 01 - Articolo su rivista
rivista: ANNALI DELL'ISTITUTO SUPERIORE DI SANITÀ (Latest publisher: Roma: Istituto Superiore di Sanità Roma: Istituto poligrafico dello stato) pp. 115-121 - issn: 0021-2571 - wos: (0) - scopus: 2-s2.0-0025984387 (2)

2108/68035 - 1991 - Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C
Graziani, Grazia - 01 - Articolo su rivista
rivista: EMBO JOURNAL (attuale: NATURE PUBLISHING GROUP, 345 PARK AVENUE SOUTH, NEW YORK, USA, NY, 10010-1707 Precedente: Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485) pp. 3215-3220 - issn: 0261-4189 - wos: WOS:A1991GK97300012 (39) - scopus: 2-s2.0-0026093690 (37)

2108/68044 - 1991 - Dominant dysplasia of the lens in transgenic mice expressing the dbl oncogene
Graziani, Grazia - 01 - Articolo su rivista
rivista: THE NEW BIOLOGIST (W B Saunders Company:Fulfillment Department, The Curtis Center, Independence Square West:Philadelphia, PA 19106:(800)654-2452, (215)238-7800, EMAIL: wbspcs@harcourt.com, INTERNET: http://elsevierhealth.com, Fax: (215)238-6445) pp. 158-168 - issn: 1043-4674 - wos: WOS:A1991GK71700011 (14) - scopus: 2-s2.0-0025852372 (16)

2108/68046 - 1991 - Requirement of phospholipase C-catalyzed hydrolysis of phosphatidylcholine for maturation of Xenopus laevis oocytes in response to insulin and ras p21
Graziani, Grazia - 01 - Articolo su rivista
rivista: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 6825-6829 - issn: 0021-9258 - wos: WOS:A1991FG72700030 (62) - scopus: 2-s2.0-0025834592 (60)

2108/68041 - 1989 - The N-terminal region of proto-dbl down regulates its transforming activity
Graziani, Grazia - 01 - Articolo su rivista
rivista: ONCOGENE (Macmillan Magazines Limited:Porters South Crinian Street, London N1 9XW United Kingdom:011 44 207 8334000, 011 44 171 8434982, Fax: 011 44 207 812358) pp. 1067-1072 - issn: 0950-9232 - wos: (0) - scopus: 2-s2.0-0024393426 (48)

2108/68043 - 1989 - The human dbl-proto-oncogene product is a cytoplasmic phosphoprotein which is associated with the cytoskeletal matrix
Graziani, Grazia - 01 - Articolo su rivista
rivista: ONCOGENE (Macmillan Magazines Limited:Porters South Crinian Street, London N1 9XW United Kingdom:011 44 207 8334000, 011 44 171 8434982, Fax: 011 44 207 812358) pp. 823-829 - issn: 0950-9232 - wos: (0) - scopus: 2-s2.0-0024319658 (37)

2108/68047 - 1988 - Depression of early phase of HTLV-I infection in vitro mediated by human beta-interferon
Perno, Carlo-Federico; Graziani, Grazia - 01 - Articolo su rivista
rivista: BRITISH JOURNAL OF CANCER (London: Springer Nature Basingstoke Hampshire UK: 3 London: H K Lewis and Co Ltd, 1947-) pp. 481-488 - issn: 0007-0920 - wos: (0) - scopus: 2-s2.0-0023885020 (19)

2108/53917 - 1988 - Effect of hydrocortisone on human natural killer activity and its modulation by beta interferon
Graziani, Grazia; Aquino, Angelo - 01 - Articolo su rivista
rivista: INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 687-694 - issn: 0192-0561 - wos: (0) - scopus: 2-s2.0-0023710770 (6)

2108/68743 - 1987 - Combined effect of cyclophosphamide and beta interferon on the generation of killer cells activated with interleukin-2
Graziani, Grazia; Aquino, Angelo - 02 - Intervento a convegno
congresso: III Congresso Nazionale Italian Society of Immunopharmacology (ISIPHAR). (Milano)

2108/68048 - 1987 - Increased susceptibility of peripheral mononuclear cells of leukemic patients to HTLV-I infection in vitro
Graziani, Grazia - 01 - Articolo su rivista
rivista: BLOOD (New York: Elsevier Inc. [Washington DC etc.]: American Society of Hematology) pp. 1175-1181 - issn: 0006-4971 - wos: (0) - scopus: 2-s2.0-0023176381 (12)

2108/68049 - 1985 - Decline of natural cytotoxicity of human lymphocytes following infection with human T-cell leukemia/lymphoma virus (HTLV)
De Vecchis, Liana; Graziani, Grazia; Macchi, Beatrice - 01 - Articolo su rivista
rivista: LEUKEMIA RESEARCH (Oxford,United Kingdom: Elsevier Science Limited -Oxford : Pergamon, 1977-) pp. 349-355 - issn: 0145-2126 - wos: (0) - scopus: 2-s2.0-0021991125 (18)

2108/68766 - 1985 - Immunological aspects of infection with human T cells leukemia/lymphoma virus (HTLV)
Graziani, Grazia; De Vecchis, Liana - 02 - Intervento a convegno
congresso: Experimental Medicine: a joint meeting between University and CNR (Roma)

2108/68763 - 1985 - Drug dependent cellular cytotoxicity in mouse thymus cells
Graziani, Grazia; Aquino, Angelo - 02 - Intervento a convegno
congresso: Experimental Medicine: a joint meeting between University and CNR (Roma)

2108/68771 - 1985 - Antigenic changes induced in tumor cells in vivo by dimethil-imidazole carboxamide (DTIC)
Graziani, Grazia - 02 - Intervento a convegno
congresso: Experimental Medicine: a joint meeting between University and CNR (Roma)

2108/68775 - 1984 - Drug-Interferon interaction on the susceptibility of lymphoma cells to NK-mediated cytolysis
Graziani, Grazia - 02 - Intervento a convegno
congresso: ICOG meeting: genetic and phenotypic markers of tumors (Roma)

2108/68773 - 1984 - Differential profile of NK target structures (NKTS) of mouse fibroblasts and lymphoma cells
Graziani, Grazia - 02 - Intervento a convegno
congresso: ICOG meeting: genetic and phenotypic markers of tumors (Roma)

2108/68051 - 1984 - Interferon-induced changes in the susceptibility of murine and human lymphoma cells to natural cytotoxic lymphocytes
Graziani, Grazia - 01 - Articolo su rivista
rivista: INTERNATIONAL JOURNAL OF TISSUE REACTIONS (Bioscience Ediprint Incorporated:Rue Alexandre Gavard 16, 1227 Carouge Geneva Switzerland:011 41 22 3003383, EMAIL: smey@bioscience-ediprint.ch, Fax: 011 41 22 3002489) pp. 35-41 - issn: 0250-0868 - wos: (0) - scopus: 2-s2.0-0021344093 (3)

2108/68777 - 1984 - Susceptibility of lymphoma cells bearing human T leukemia/lymphoma virus (HTLV) to NK-mediated cytolysis
Graziani, Grazia; De Vecchis, Liana; Macchi, Beatrice - 02 - Intervento a convegno
congresso: ICOG meeting: genetic and phenotypic markers of tumors (Roma)

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