FRANCESCA SACCO

Associate professor


email: francesca.sacco@uniroma2.it
phone: 0672594399
building: SOGENE
room: 4323

Education and training

2006  Degree in Bachelor degree cum laude in Cellular and Molecular Biology, University of Rome Tor Vergata

2008 Master degree cum laude in Cellular and Molecular Biology, University of Rome Tor Vergata

2011 PhD in Cellular and Molecular Biology, University of Rome Tor Vergata

Employment

2011-2012 Bridge PostDoc in the laboratory of Molecular Genetics, directed by Prof. Gianni Cesareni, at the University of Rome Tor Vergata

2012-2017 PostDoc in Dept of Biochemistry, directed by Prof. Matthias Mann, at the Max Plank Institute of Biochemistry (Munich)

2017-2018 Women in Science fellowship,  Dept of Molecular Genetics at the University of Rome Tor Vergata

2018-2021 Rita Levi Montalcini Assistant Professor

2019-present PI

2020-present Coordinator of Phosphoproteomics, TIGEM

2021- present Associate Professor

Teaching

2021-present: Genomics and statistics, at the Bioinformatic Master Degree

2020-present: Systems Biology at the Cellular and Molecular Biology Master Degree

Honours

•             2019-2024: AIRC Start-up grant (5% success rate).

•             2018-2021: Rita Levi Montalcini award (10% success rate)

•             2017-2018: L’Oreal for Women in Science fellowship (2% success rate)

•             2012-2015: EMBO Long Term Fellowship

 

Research interests: Dysregulation of signaling pathways is often implicated in complex disease onset and progression. We integrate mass spectrometry (MS)-based (phospho)proteomics with network-based techniques to obtain context-specific predictive mathematical models. These models undergo in silico testing and in vitro and in vivo validation is performed to identify pharmacological interventions capable of reversing the pathological phenotype.

https://www.francescasaccolab.org

Research products

2108/357743 - 2024 - Unveiling the signaling network of FLT3-ITD AML improves drug sensitivity prediction
Latini, Sara; Venafra, Veronica; Massacci, Giorgia; Bica, Valeria; Graziosi, Simone; Pugliese, Giusj Monia; Iannuccelli, Marta; Pepe, Gerardo; Helmer Citterich, Manuela; Perfetto, Livia; Sacco, Francesca - 01 - Articolo su rivista
paper: ELIFE (Cambridge: eLife Sciences Publications) pp. - - issn: 2050-084X - wos: WOS:001196100200001 (0) - scopus: (0)

2108/387923 - 2024 - SignalingProfiler 2.0 a network-based approach to bridge multi-omics data to phenotypic hallmarks
Venafra, Veronica; Sacco, Francesca; Perfetto, Livia - 01 - Articolo su rivista
paper: NPJ SYSTEMS BIOLOGY AND APPLICATIONS (London : Nature Partner Journals) pp. - - issn: 2056-7189 - wos: WOS:001297110900001 (0) - scopus: 2-s2.0-85201936917 (0)

2108/387943 - 2024 - Quinoin, type 1 ribosome inactivating protein alters SARS-CoV-2 viral replication organelle restricting viral replication and spread
Sacco, Francesca - 01 - Articolo su rivista
paper: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (-Attuale :ELSEVIER SCIENCE BV, PO BOX 211, AMSTERDAM, NETHERLANDS, 1000 AE -Butterworth Heinemann Publishers:Linacre House Jordan Hill, Oxford OX2 8DP United Kingdom:011 44 1865 314569, EMAIL: bhmarketing@repp.co.uk, INTERNET: http://www.laxtonsprices.co.uk, Fax: 011 44 1865 314569) pp. - - issn: 0141-8130 - wos: WOS:001324313600001 (0) - scopus: 2-s2.0-85204451057 (0)

2108/387944 - 2024 - Stage-dependent phosphoproteome remodeling of Parkinson's disease blood cells
Massacci, Giorgia; Venafra, Veronica; Cerroni, Rocco; Bissacco, Jacopo; Perfetto, Livia; Stefani, Alessandro; Mercuri, Nicola Biagio; Schirinzi, Tommaso; Sacco, Francesca - 01 - Articolo su rivista
paper: NEUROBIOLOGY OF DISEASE ([Oxford] : Blackwell Science) pp. - - issn: 1095-953X - wos: WOS:001290813100001 (0) - scopus: 2-s2.0-85200327069 (0)

2108/310177 - 2023 - A key role of the WEE1-CDK1 axis in mediating TKI-therapy resistance in FLT3-ITD positive acute myeloid leukemia patients
Perfetto, Livia; Sacco, Francesca - 01 - Articolo su rivista
paper: LEUKEMIA (-, LONDON, ENGLAND: NATURE PUBLISHING GROUP, -London,United Kingdom: Macmillan Magazines Limited -[Baltimore, Md.] : Williams & Wilkins, [c1987]-) pp. 288-297 - issn: 0887-6924 - wos: WOS:000898331300001 (7) - scopus: 2-s2.0-85143763800 (7)

2108/348284 - 2023 - The Cyclin-dependent kinase 1: more than a cell cycle regulator
Massacci, Giorgia; Perfetto, Livia; Sacco, Francesca - 01 - Articolo su rivista
paper: BRITISH JOURNAL OF CANCER (Houndmills Basingstoke Hampshire: Nature Pub. Group London: Harcourt Publishers.) pp. 1707-1716 - issn: 1532-1827 - wos: WOS:001099067900002 (16) - scopus: 2-s2.0-85175088850 (15)

2108/348248 - 2023 - Impact of FLT3-ITD location on cytarabine sensitivity in AML: a network-based approach
Pugliese, Giusj Monia; Venafra, Veronica; Bica, Valeria; Massacci, Giorgia; Latini, Sara; Graziosi, Simone; Perfetto, Livia; Sacco, Francesca - 01 - Articolo su rivista
paper: LEUKEMIA (-, LONDON, ENGLAND: NATURE PUBLISHING GROUP, -London,United Kingdom: Macmillan Magazines Limited -[Baltimore, Md.] : Williams & Wilkins, [c1987]-) pp. 1151-1155 - issn: 0887-6924 - wos: WOS:000952382300001 (3) - scopus: 2-s2.0-85150617778 (2)

2108/309616 - 2023 - Caspase-8 as a novel mediator linking Src kinase signaling to enhanced glioblastoma malignancy
Cirotti, Claudia; Sacco, Francesca; Volpe, Elisabetta; Barila', Daniela - 01 - Articolo su rivista
paper: CELL DEATH AND DIFFERENTIATION (Nature Publishing Group:Brunel Road Houndmills, Basingstoke RG21 6XS United Kingdom:011 44 20 78334000, EMAIL: institutions@natureny.com, INTERNET: http://www.nature.com, Fax: 011 44 20 78434640) pp. 417-428 - issn: 1350-9047 - wos: WOS:000912614200001 (8) - scopus: 2-s2.0-85143211440 (8)

2108/308396 - 2022 - Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy
Reggio, Alessio; Sacco, Francesca - 01 - Articolo su rivista
paper: SCIENCE ADVANCES (Washington, DC : American Association for the Advancement of Science, 2015-) pp. - - issn: 2375-2548 - wos: WOS:000926552600001 (15) - scopus: 2-s2.0-85137041468 (15)

2108/308395 - 2022 - Phosphoproteomics and Organelle Proteomics in Pancreatic Islets
Sacco, Francesca - 01 - Articolo su rivista
paper: Methods in Molecular Biology (John M. Walker) pp. 123-140 - issn: - wos: (0) - scopus: (0)

2108/266664 - 2021 - Integrating Patient-Specific Information into Logic Models of Complex Diseases: Application to Acute Myeloid Leukemia
Iannuccelli, Marta; Licata, Luana; Perfetto, Livia; Castagnoli, Luisa; Cesareni, Giovanni; Sacco, Francesca - 01 - Articolo su rivista
paper: JOURNAL OF PERSONALIZED MEDICINE (Basel: MDPI AG, 2011-) pp. - - issn: 2075-4426 - wos: WOS:000622705700001 (3) - scopus: 2-s2.0-85101196769 (4)

2108/308476 - 2021 - COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms
Conti, Maria Cristina; Licata, Luana; Iannuccelli, Marta; Sacco, Francesca; Soliman, Sherif - 01 - Articolo su rivista
paper: MOLECULAR SYSTEMS BIOLOGY (London : Nature Pub. Group) pp. - - issn: 1744-4292 - wos: WOS:000711353900001 (44) - scopus: 2-s2.0-85118262224 (47)

2108/284987 - 2021 - Assembling disease networks from causal interaction resources
Cesareni, Giovanni; Sacco, Francesca; Perfetto, Livia - 01 - Articolo su rivista
paper: FRONTIERS IN GENETICS (Lausanne : Frontiers Research Foundation, 2010-) pp. - - issn: 1664-8021 - wos: WOS:000665763300001 (3) - scopus: 2-s2.0-85108874484 (3)

2108/284989 - 2021 - Combining mass spectrometry-based phosphoproteomics with a network-based approach to reveal FLT3-dependent mechanisms of chemoresistance
Perfetto, Livia; Sacco, Francesca - 01 - Articolo su rivista
paper: PROTEOMES (Basel: MDPI) pp. - - issn: 2227-7382 - wos: WOS:000666795600001 (3) - scopus: 2-s2.0-85106693219 (3)

2108/288561 - 2021 - A Resource for the Network Representation of Cell Perturbations Caused by SARS-CoV-2 Infection
Perfetto, Livia; Micarelli, Elisa; Iannuccelli, Marta; Fuoco, Claudia; Paoluzi, Serena; Castagnoli, Luisa; Cesareni, Giovanni; Licata, Luana; Sacco, Francesca - 01 - Articolo su rivista
paper: GENES (Basel : Molecular Diversity Preservation International) pp. 450- - issn: 2073-4425 - wos: WOS:000633658000001 (5) - scopus: 2-s2.0-85103098209 (6)

2108/288565 - 2021 - COVID-19 Disease Map, a computational knowledge repository of virus-host interaction mechanisms (vol 17, e10387, 2021)
Conti, Maria Cristina; Licata, Luana; Iannuccelli, Marta; Sacco, Francesca; Soliman, Sherif - 01 - Articolo su rivista
paper: MOLECULAR SYSTEMS BIOLOGY (London : Nature Pub. Group) pp. e10851- - issn: 1744-4292 - wos: WOS:000735404400001 (44) - scopus: 2-s2.0-85122102471 (9)

2108/295651 - 2021 - Skeletal muscle subpopulation rearrangements upon rhabdomyosarcoma development through single-cell mass cytometry
Gargioli, Cesare; Sacco, Francesca; Cesareni, Giovanni; Castagnoli, Luisa; Fuoco, Claudia - 01 - Articolo su rivista
paper: JOURNAL OF CLINICAL MEDICINE (MDPI Publishing, Basel, Switzerland) pp. 1-22 - issn: 2077-0383 - wos: WOS:000624028900001 (4) - scopus: 2-s2.0-85114068784 (4)

2108/257725 - 2020 - Adipogenesis of skeletal muscle fibro/adipogenic progenitors is affected by the WNT5a/GSK3/β-catenin axis
Reggio, Alessio; Rosina, Marco; Cerquone Perpetuini, Andrea; Petrilli, Lucia Lisa; Gargioli, Cesare; Fuoco, Claudia; Micarelli, Elisa; Sacco, Francesca; Castagnoli, Luisa - 01 - Articolo su rivista
paper: CELL DEATH AND DIFFERENTIATION (Basingstoke: Nature Publishing Group.) pp. 2921-2941 - issn: 1476-5403 - wos: WOS:000530981500001 (82) - scopus: 2-s2.0-85085079338 (81)

2108/264307 - 2020 - MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B.
Sacco, Francesca - 01 - Articolo su rivista
paper: EMBO JOURNAL (Weinheim : Wiley) pp. - - issn: 1460-2075 - wos: WOS:000552394100001 (58) - scopus: 2-s2.0-85088583490 (62)

2108/229802 - 2020 - Metabolic reprogramming of fibro/adipogenic progenitors facilitates muscle regeneration
Reggio, Alessio; Rosina, Marco; Petrilli, Lucia Lisa; Testa, Stefano; Gargioli, Cesare; Fuoco, Claudia; Castagnoli, Luisa; Cesareni, Giovanni; Sacco, Francesca - 01 - Articolo su rivista
paper: LIFE SCIENCE ALLIANCE ([Woodbury NY]: Life Science Alliance LLC, [2018]-) pp. e202000646- - issn: 2575-1077 - wos: WOS:000523303300009 (37) - scopus: 2-s2.0-85079003594 (37)

2108/241930 - 2019 - Myo-REG: A portal for signaling interactions in muscle regeneration
Palma, Alessandro; Fuoco, Claudia; Gargioli, Cesare; Iannuccelli, Marta; Licata, Luana; Micarelli, Elisa; Paoluzi, Serena; Perfetto, Livia; Petrilli, Lucia Lisa; Reggio, Alessio; Rosina, Marco; Sacco, Francesca; Castagnoli, Luisa; Cesareni, Giovanni - 01 - Articolo su rivista
paper: FRONTIERS IN PHYSIOLOGY (Lausanne: Frontiers Research Foundation, 2010-) pp. 1216- - issn: 1664-042X - wos: WOS:000488077300001 (7) - scopus: 2-s2.0-85073006415 (6)

2108/241710 - 2019 - Phosphoproteomics Reveals the GSK3-PDX1 Axis as a Key Pathogenic Signaling Node in Diabetic Islets
Sacco, Francesca; Reggio, Alessio - 01 - Articolo su rivista
paper: CELL METABOLISM ([Cambridge, MA] : Cell Press, [2005]-) pp. 1422-1432.e3 - issn: 1932-7420 - wos: WOS:000470097200018 (67) - scopus: 2-s2.0-85066234805 (68)

2108/311667 - 2019 - Fibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesis
Marinkovic, Milica; Fuoco, Claudia; Sacco, Francesca; Cerquone Perpetuini, Andrea; Micarelli, Elisa; Pavlidou, Theodora; Petrilli, Lucia Lisa; Reggio, Alessio; Spada, Filomena; Castagnoli, Luisa; Gargioli, Cesare - 01 - Articolo su rivista
paper: LIFE SCIENCE ALLIANCE ([Woodbury NY]: Life Science Alliance LLC, [2018]-) pp. 1-17 - issn: 2575-1077 - wos: WOS:000473222200028 (40) - scopus: (0)

2108/241933 - 2019 - SILAC-based quantitative proteomics using mass spectrometry quantifies endoplasmic reticulum stress in whole HeLa cells
Sacco, Francesca - 01 - Articolo su rivista
paper: DISEASE MODELS & MECHANISMS (Cambridge : Company of Biologists, 2007-) pp. dmm040741- - issn: 1754-8403 - wos: WOS:000500692600006 (11) - scopus: 2-s2.0-85074965532 (11)

2108/234339 - 2018 - Combining Phosphoproteomics Datasets and Literature Information to Reveal the Functional Connections in a Cell Phosphorylation Network
Sacco, Francesca; Perfetto, Livia; Cesareni, Giovanni - 01 - Articolo su rivista
paper: PROTEOMICS (Wiley-VCH Verlag GmBH:PO Box 101161, D 69451 Weinheim Germany:011 49 6201 606147, EMAIL: service@wiley-vch.de, INTERNET: http://www.wiley-vch.de, Fax: 011 49 6201 606328) pp. e1700311- - issn: 1615-9853 - wos: WOS:000428343700003 (16) - scopus: 2-s2.0-85044424675 (18)

2108/241709 - 2016 - IKAP: A heuristic framework for inference of kinase activities from Phosphoproteomics data
Sacco, Francesca - 01 - Articolo su rivista
paper: BIOINFORMATICS ([Oxford] : Oxford University Press) pp. 424-431 - issn: 1367-4811 - wos: WOS:000370203000014 (51) - scopus: 2-s2.0-84962326141 (49)

2108/266922 - 2016 - Dissection of CD20 regulation in lymphoma using RNAi
Sacco, Francesca - 01 - Articolo su rivista
paper: LEUKEMIA (-, LONDON, ENGLAND: NATURE PUBLISHING GROUP, -London,United Kingdom: Macmillan Magazines Limited -[Baltimore, Md.] : Williams & Wilkins, [c1987]-) pp. 2409-2412 - issn: 0887-6924 - wos: WOS:000390773400016 (12) - scopus: 2-s2.0-84988369322 (10)

2108/266920 - 2016 - Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion
Sacco, Francesca - 01 - Articolo su rivista
paper: NATURE COMMUNICATIONS (London: Nature Publishing Group-Springer Nature) pp. - - issn: 2041-1723 - wos: WOS:000387558800001 (67) - scopus: 2-s2.0-84995426602 (69)

2108/175512 - 2016 - The cell-autonomous mechanisms underlying the activity of metformin as an anticancer drug.
Sacco, Francesca; Calderone, Alberto; Castagnoli, Luisa; Cesareni, Giovanni - 01 - Articolo su rivista
paper: BRITISH JOURNAL OF CANCER (London: Springer Nature Basingstoke Hampshire UK: 3 London: H K Lewis and Co Ltd, 1947-) pp. 1451-1456 - issn: 0007-0920 - wos: WOS:000390760300004 (21) - scopus: 2-s2.0-84996635713 (25)

2108/234343 - 2016 - Deep Proteomics of Breast Cancer Cells Reveals that Metformin Rewires Signaling Networks Away from a Pro-growth State
Sacco, Francesca; Pirro', Stefano; Gherardini, Pier Federico; Castagnoli, Luisa; Cesareni, Giovanni - 01 - Articolo su rivista
paper: CELL SYSTEMS (Cambridge, MA : Cell Press ; Philadelphia, PA : Elsevier) pp. 159-171 - issn: 2405-4712 - wos: WOS:000394358800006 (65) - scopus: 2-s2.0-84959286939 (73)

2108/234335 - 2016 - A subset of RAB proteins modulates PP2A phosphatase activity
Sacco, Francesca; Panni, Simona; Santonico, Elena; Castagnoli, Luisa; Cesareni, Giovanni - 01 - Articolo su rivista
paper: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. 32857- - issn: 2045-2322 - wos: WOS:000382783000001 (5) - scopus: 2-s2.0-84987648017 (5)

2108/129198 - 2015 - Alterations in the phosphoproteomic profile of cells expressing a non-functional form of the SHP2 phosphatase
Sacco, Francesca; Cesareni, Giovanni; Castagnoli, Luisa - 01 - Articolo su rivista
paper: NEW BIOTECHNOLOGY (Amsterdam : Elsevier Life Science) pp. - - issn: 1871-6784 - wos: WOS:000378026000006 (6) - scopus: 2-s2.0-84940860131 (6)

2108/96309 - 2014 - Combining affinity proteomics and network context to identify new phosphatase substrates and adapters in growth pathways
Sacco, Francesca; Paoluzi, Serena; Castagnoli, Luisa; Cesareni, Giovanni - 01 - Articolo su rivista
paper: FRONTIERS IN GENETICS (Lausanne : Frontiers Research Foundation, 2010-) pp. 1-15 - issn: 1664-8021 - wos: WOS:000347057100001 (13) - scopus: 2-s2.0-84905652854 (12)

2108/77075 - 2013 - HuPho: the human phosphatase portal
Sacco, Francesca; Santonico, Elena; Castagnoli, Luisa; Cesareni, Giovanni - 01 - Articolo su rivista
paper: THE FEBS JOURNAL (Blackwell Pub., Oxford, UK) pp. 379-387 - issn: 1742-464X - wos: WOS:000313906000004 (50) - scopus: 2-s2.0-84872816249 (52)

2108/77344 - 2013 - The SH2 domain interaction landscape
Sacco, Francesca; Paoluzi, Serena; Castagnoli, Luisa; Cesareni, Giovanni - 01 - Articolo su rivista
paper: CELL REPORTS (Elsevier B.V. Cambridge MA: Cell Press) pp. 1293-1305 - issn: 2211-1247 - wos: WOS:000321897100031 (90) - scopus: 2-s2.0-84876957035 (96)

2108/77894 - 2012 - The human phosphatase interactome: An intricate family portrait
Sacco, Francesca; Castagnoli, Luisa; Cesareni, Giovanni - 01 - Articolo su rivista
paper: FEBS LETTERS (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 2732-2739 - issn: 0014-5793 - wos: WOS:000307295200021 (167) - scopus: 2-s2.0-84864583212 (175)

2108/77888 - 2012 - MINT, the molecular interaction database: 2012 update
Licata, Luana; Sacco, Francesca; Santonico, Elena; Castagnoli, Luisa; Cesareni, Giovanni - 01 - Articolo su rivista
paper: NUCLEIC ACIDS RESEARCH (Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485 Editore precedente: Information Retrieval ltd., London) pp. D857-D857-61 - issn: 0305-1048 - wos: WOS:000298601300128 (748) - scopus: 2-s2.0-84860918589 (812)

2108/77892 - 2012 - Mapping the human phosphatome on growth pathways
Sacco, Francesca; Gherardini, Pier Federico; Paoluzi, Serena; Helmer Citterich, Manuela; Ragnini, Antonella; Castagnoli, Luisa; Cesareni, Giovanni - 01 - Articolo su rivista
paper: MOLECULAR SYSTEMS BIOLOGY (London : Nature Pub. Group) pp. 603-603 - issn: 1744-4292 - wos: WOS:000308316400003 (20) - scopus: 2-s2.0-84868282067 (19)

2108/96343 - 2012 - The 4G10, pY20 and p-TYR-100 antibody specificity: profiling by peptide microarrays
Sacco, Francesca; Castagnoli, Luisa; Cesareni, Giovanni - 01 - Articolo su rivista
paper: NEW BIOTECHNOLOGY (Amsterdam : Elsevier Life Science) pp. 571-577 - issn: 1871-6784 - wos: WOS:000305606500009 (47) - scopus: 2-s2.0-84862021667 (48)

2108/96313 - 2012 - The 4G10, pY20 and p-TYR-100 antibody specificity: profiling by peptide microarrays
Tinti, Michele; Castagnoli, Luisa; Cesareni, Giovanni; Sacco, Francesca - 01 - Articolo su rivista
paper: NEW BIOTECHNOLOGY (Amsterdam : Elsevier Life Science) pp. 571-577 - issn: 1871-6784 - wos: WOS:000305606500009 (47) - scopus: 2-s2.0-84862021667 (48)

2108/42510 - 2011 - PTPRJ (protein tyrosine phosphatase, receptor type, J)
Sacco, Francesca; Castagnoli, Luisa - 04 - Monografia

2108/8357 - 2009 - VirusMINT: a viral protein interaction database
Sacco, Francesca; Castagnoli, Luisa; Cesareni, Giovanni - 01 - Articolo su rivista
paper: NUCLEIC ACIDS RESEARCH (Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485 Editore precedente: Information Retrieval ltd., London) pp. D669-73- - issn: 0305-1048 - wos: WOS:000261906200119 (163) - scopus: 2-s2.0-58149199573 (176)

2108/8358 - 2009 - Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases
Sacco, Francesca; Castagnoli, Luisa; Cesareni, Giovanni - 01 - Articolo su rivista
paper: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 22048-58- - issn: 0021-9258 - wos: WOS:000268783700029 (63) - scopus: 2-s2.0-69249142851 (65)

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