ALESSANDRA GAMBACURTA

Professore associato


email: gambacur@uniroma2.it
telefono: 6488
edificio: F NORD
stanza: 188

Alessandra Gambacurta è entrata a far parte del Dipartimento di Medicina Sperimentale dell'Università di Roma “Tor Vergata”, inizialmente come Ricercatore nel 1994, dopo aver conseguito il Dottorato di Ricerca in Biochimica nel 1992 (Università di Roma “La Sapienza”. È Professore Associato per la Cattedra di Biologia Molecolare nel Corso di Laurea in Ingegneria Medica, nel Corso di Diploma in Tecniche Diagnostiche di Laboratorio Biomedico e nella Scuola di Specializzazione in Ricerca in Microbiologia Clinica e Virologia.
• Studio dei meccanismi molecolari ed epigenetici alla base della deprogrammazione cellulare delle cellule nucleate del sangue;
• Studio dei meccanismi di differenziamento nelle cellule staminali del sangue (BDSC);
• Applicazione delle cellule staminali del sangue in medicina veterinaria (cavalli, cani, gatti) su patologie non indotte, con particolare riguardo a tendini, muscoli e ossa;
• Riprogrammazione di cellule tumorali in cellule normali con particolare attenzione ai meccanismi epigenetici e molecolari coinvolti nel transdifferenziamento;
• Ruolo del metabolismo energetico nella riprogrammazione delle cellule tumorali differenziate, identificazione della cascata molecolare (epigenetica e proteica) responsabile del cambiamento metabolico;
• Studio del "rimodellamento della cromatina" in relazione alla relazione tra modificazioni epigenetiche, regolazione dell'espressione genica e cambiamenti metabolici\morfologici di cellule tumorali e staminali;
• Identificazione di marcatori epigenetici per una diagnosi precoce del tumore;
• Sviluppo di un lab-on-chip (dispositivo microfluidico) per il rilevamento di cellule tumorali nei fluidi biologici

Gambacurta Alessandra ORCID: https://orcid.org/0000-0001-5657-1847

Produzione scientifica

2108/391965 - 2025 - In Vitro Cell-Based MTT and Crystal Violet Assays for Drug Toxicity Screening
Gambacurta, Alessandra; Tullio, Valentina; Savini, Isabella; Catani, Maria Valeria; Gasperi, Valeria - 03 - Contributo in libro
libro: Computational Toxicology - (978-1-0716-4002-9)

2108/394563 - 2024 - Correction: Microcalcifications Drive Breast Cancer Occurrence and Development by Macrophage-Mediated Epithelial to Mesenchymal Transition (International Journal of Molecular Sciences, (2019), 20, 22, (5633), 10.3390/ijms20225633)
Scimeca, Manuel; Bonfiglio, Rita; Albonici, Loredana; Mauriello, Alessandro; Schillaci, Orazio; Gambacurta, Alessandra; Bonanno, Elena - 01 - Articolo su rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:001287874100001 (0) - scopus: 2-s2.0-85200841453 (0)

2108/347723 - 2023 - Partial Loss of Function ABCA12 Mutations Generate Reduced Deposition of Glucosyl-Ceramide, Leading to Patchy Ichthyosis and Erythrodermia Resembling Erythrokeratodermia Variabilis et Progressiva (EKVP)
Terrinoni, Alessandro; Bruno, Ernesto; Pitolli, Consuelo; Minieri, Marilena; Pieri, Massimo; Gambacurta, Alessandra; Campione, Elena; Belardi, Riccardo; Bernardini, Sergio - 01 - Articolo su rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:001073979500001 (3) - scopus: 2-s2.0-85172770025 (3)

2108/361843 - 2023 - In Vivo Identification of H3K9me2/H3K79me3 as an Epigenetic Barrier to Carcinogenesis
Piro, Maria Cristina; Gasperi, Valeria; De Stefano, Alessandro; Anemona, Lucia; Montanaro, Manuela; Mauriello, Alessandro; Catani, Maria Valeria; Terrinoni, Alessandro; Gambacurta, Alessandra - 01 - Articolo su rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 1-16 - issn: 1422-0067 - wos: WOS:001046314500001 (1) - scopus: 2-s2.0-85167754486 (1)

2108/289387 - 2020 - Opening the Gate to the Serism Project: From Earth to Space and Back
Gambacurta, Alessandra - 01 - Articolo su rivista
rivista: AEROTECNICA MISSILI & SPAZIO ([Cham]: Springer International Publishing Pisa: Associazione Italiana di Aeronautica e Astronautica) pp. 87-91 - issn: 2524-6968 - wos: (0) - scopus: (0)

2108/258728 - 2020 - DHA Affects Microtubule Dynamics Through Reduction of Phospho-TCTP Levels and Enhances the Antiproliferative Effect of T-DM1 in Trastuzumab-Resistant HER2-Positive Breast Cancer Cell Lines
D'amico, Silvia; Ranalli, Marco; Gambacurta, Alessandra; Bernassola, Francesca - 01 - Articolo su rivista
rivista: CELLS (Basel: mdpi-Molecular Diversity Preservation International) pp. - - issn: 2073-4409 - wos: WOS:000539340200194 (15) - scopus: 2-s2.0-85085157116 (13)

2108/214676 - 2019 - Human osteogenic differentiation in Space: proteomic and epigenetic clues to better understand osteoporosis
Gambacurta, Alessandra; Bari, Monica - 01 - Articolo su rivista
rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. - - issn: 2045-2322 - wos: WOS:000470243800024 (34) - scopus: 2-s2.0-85067477530 (40)

2108/221731 - 2019 - Microcalcifications Drive Breast Cancer Occurrence and Development by Macrophage-Mediated Epithelial to Mesenchymal Transition.
Scimeca, Manuel; Bonfiglio, Rita; Albonici, Loredana; Mauriello, Alessandro; Schillaci, Orazio; Gambacurta, Alessandra; Bonanno, Elena - 01 - Articolo su rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:000502786800115 (34) - scopus: 2-s2.0-85074921448 (37)

2108/258730 - 2019 - Microcalcifications Drive Breast Cancer Occurrence and Development by Macrophage-Mediated Epithelial to Mesenchymal Transition
Scimeca, Manuel; Bonfiglio, Rita; Albonici, Loredana; Mauriello, Alessandro; Schillaci, Orazio; Gambacurta, Alessandra; Bonanno, Elena - 01 - Articolo su rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 5633- - issn: 1422-0067 - wos: WOS:000502786800115 (34) - scopus: 2-s2.0-85074921448 (37)

2108/207626 - 2019 - Cell death in cancer in the era of precision medicine
Melino, Gennaro; Gambacurta, Alessandra - 01 - Articolo su rivista
rivista: GENES AND IMMUNITY (Nature Publishing Group:Brunel Road Houndmills, Basingstoke RG21 6XS United Kingdom:011 44 20 78334000, EMAIL: institutions@natureny.com, INTERNET: http://www.nature.com, Fax: 011 44 20 78434640) pp. 529-538 - issn: 1466-4879 - wos: WOS:000487930200002 (6) - scopus: 2-s2.0-85055330558 (9)

2108/207628 - 2018 - Myoblasts rely on TAp63 to control basal mitochondria respiration
Ciuffoli, Veronica; Lena, Anna Maria; Gambacurta, Alessandra; Candi, Eleonora - 01 - Articolo su rivista
rivista: AGING (Impact Journals LLC) pp. 3558-3573 - issn: 1945-4589 - wos: WOS:000451853300044 (4) - scopus: 2-s2.0-85058095832 (4)

2108/207624 - 2018 - Challenging tumor resistance with less toxic, more effective drug combinations: an example from neuroblastoma
Gambacurta, Alessandra - 01 - Articolo su rivista
rivista: CELL DEATH & DISEASE (Nature Group) pp. 686- - issn: 2041-4889 - wos: WOS:000434774800010 (2) - scopus: 2-s2.0-85048225717 (2)

2108/207630 - 2018 - TAp73 regulates ATP7A: possible implications for ageing-related diseases
Panatta, Emanuele; Di Daniele, Nicola; Gambacurta, Alessandra; Amelio, Ivano - 01 - Articolo su rivista
rivista: AGING (Impact Journals LLC) pp. 3745-3760 - issn: 1945-4589 - wos: WOS:000454633200020 (4) - scopus: 2-s2.0-85059312519 (5)

2108/207620 - 2018 - Human Endogenous Retrovirus K in the Crosstalk Between Cancer Cells Microenvironment and Plasticity: A New Perspective for Combination Therapy
Balestrieri, Emanuela; Denboba, Ayele Argaw; Gambacurta, Alessandra; Cipriani, Chiara; Bei, Roberto; Sinibaldi, Paola; Matteucci, Claudia - 01 - Articolo su rivista
rivista: FRONTIERS IN MICROBIOLOGY (Lausanne : Frontiers Research Foundation, 2010-) pp. 1448- - issn: 1664-302X - wos: WOS:000436982000001 (21) - scopus: 2-s2.0-85049382844 (21)

2108/207618 - 2017 - Rapid Rapamycin-Only Induced Osteogenic Differentiation of Blood-Derived Stem Cells and Their Adhesion to Natural and Artificial Scaffolds
Carpentieri, Arianna; Cozzoli, Eliana; Ranalli, Marco; Scimeca, Manuel; Bonanno, Elena; Gambacurta, Alessandra - 01 - Articolo su rivista
rivista: STEM CELLS INTERNATIONAL (Cairo: Hindawi Publishing Corporation) pp. 2976541- - issn: 1687-966X - wos: WOS:000407322500001 (5) - scopus: 2-s2.0-85027264242 (6)

2108/173168 - 2017 - HERV-K activation is strictly required to sustain CD133+ melanoma cells with stemness features
Balestrieri, Emanuela; Cipriani, Chiara; Bucci, Ilaria; Sorrentino, Roberta; Gambacurta, Alessandra; Sinibaldi, Paola; Matteucci, Claudia - 01 - Articolo su rivista
rivista: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (London : BioMed Central) pp. 20- - issn: 1756-9966 - wos: WOS:000392670900002 (52) - scopus: 2-s2.0-85010716519 (54)

2108/207632 - 2016 - Back on Track: New Perspectives on Cancer Cell Reprogramming
Carpentieri, Arianna; Gambacurta, Alessandra - 01 - Articolo su rivista
rivista: JOURNAL OF SINGLE CELL GENOMICS & PROTEOMICS (Los Angeles, CA : OMICS Publishing Group, [2012]-) pp. - - issn: 2168-9431 - wos: (0) - scopus: (0)

2108/194436 - 2016 - Erratum: Differentiation of human neuroblastoma cells toward the osteogenic lineage by mTOR inhibitor
Carpentieri, Arianna; Cozzoli, Eliana; Scimeca, Manuel; Bonanno, Elena; Gambacurta, Alessandra - 01 - Articolo su rivista
rivista: CELL DEATH & DISEASE (Nature Group) pp. e2202-e2202 - issn: 2041-4889 - wos: WOS:000375277600029 (5) - scopus: 2-s2.0-84989336937 (16)

2108/194377 - 2015 - Differentiation of human neuroblastoma cells toward the osteogenic lineage by mTOR inhibitor
Carpentieri, Arianna; Cozzoli, Eliana; Scimeca, Manuel; Bonanno, Elena; Gambacurta, Alessandra - 01 - Articolo su rivista
rivista: CELL DEATH & DISEASE (Nature Group) pp. e1974- - issn: 2041-4889 - wos: WOS:000367155300012 (14) - scopus: 2-s2.0-84989336937 (16)

2108/86682 - 2013 - IL-25 prevents and cures fulminant hepatitis in mice through a myeloid-derived suppressor cell-dependent mechanism
Monteleone, Ivan Salvatore; Ranalli, Marco; Colantoni, Alfredo; Gambacurta, Alessandra; Mattei, Maurizio; Pallone, Francesco; Monteleone, Giovanni - 01 - Articolo su rivista
rivista: HEPATOLOGY (Baltimore MD: Williams & Wilkins, [©1981]-) pp. 1436-1450 - issn: 0270-9139 - wos: WOS:000325150100029 (41) - scopus: 2-s2.0-84884974054 (42)

2108/82828 - 2012 - The modulation of sirtuins and apoptotic proteins in rats after exhaustive exercise
Marfe', Gabriella; Gambacurta, Alessandra; Sinibaldi, Paola - 01 - Articolo su rivista
rivista: OPEN JOURNAL OF MOLECULAR AND INTEGRATIVE PHYSIOLOGY (Irvine, CA : Scientific Research Publishing, Inc.) pp. 65-74 - issn: 2162-2167 - wos: (0) - scopus: (0)

2108/78149 - 2012 - A new clinical approach: Use of blood-derived stem cells (BDSCs) for superficial digital flexor tendon injuries in horses
Gambacurta, Alessandra - 01 - Articolo su rivista
rivista: LIFE SCIENCES (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. - - issn: 0024-3205 - wos: WOS:000304789600002 (27) - scopus: 2-s2.0-84861573870 (31)

2108/77652 - 2012 - Blood-Derived Stem Cells (BDSCs) Plasticity: In Vitro Hepatic Differentiation
Gambacurta, Alessandra - 01 - Articolo su rivista
rivista: JOURNAL OF CELLULAR PHYSIOLOGY (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. - - issn: 0021-9541 - wos: WOS:000315414000014 (7) - scopus: 2-s2.0-84874212963 (9)

2108/51916 - 2012 - Blood derived stem cells: An ameliorative therapy in veterinary ophthalmology
Marfe', Gabriella; Ranalli, Marco; Cozzoli, Eliana; Gambacurta, Alessandra - 01 - Articolo su rivista
rivista: JOURNAL OF CELLULAR PHYSIOLOGY (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. - - issn: 0021-9541 - wos: WOS:000298484800040 (25) - scopus: 2-s2.0-84155174595 (29)

2108/78151 - 2012 - ATP regulation of the ligand-binding properties in temperate and cold-adapted haemoglobins. X-ray structure and ligand-binding kinetics in the sub-Antarctic fish Eleginops maclovinus
Gambacurta, Alessandra; Coletta, Massimiliano - 01 - Articolo su rivista
rivista: MOLECULAR BIOSYSTEMS (Cambridge : Royal Society of Chemistry, 2005-) pp. 3295-3304 - issn: 1742-206X - wos: WOS:000311473200020 (11) - scopus: 2-s2.0-84868138805 (11)

2108/50968 - 2011 - Sphingosine kinase 1 overexpression is regulated by signaling through PI3K, AKT2, and mTOR in imatinib-resistant chronic myeloid leukemia cells
Gambacurta, Alessandra; Sinibaldi, Paola; De Fabritiis, Paolo; Amadori, Sergio - 01 - Articolo su rivista
rivista: EXPERIMENTAL HEMATOLOGY (Elsevier Science Incorporated / NY Journals:Madison Square Station, PO Box 882:New York, NY 10159:(212)633-3730, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: (212)633-3680) pp. 653-665 - issn: 0301-472X - wos: (0) - scopus: 2-s2.0-79956274055 (37)

2108/16348 - 2011 - Sphingosine kinase 1 overexpression is regulated by signaling through PI3K, AKT2, and mTOR in imatinib-resistant chronic myeloid leukemia cells.
Gambacurta, Alessandra; Sinibaldi, Paola - 01 - Articolo su rivista
rivista: EXPERIMENTAL HEMATOLOGY (Elsevier Science Incorporated / NY Journals:Madison Square Station, PO Box 882:New York, NY 10159:(212)633-3730, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: (212)633-3680) pp. 653-665 - issn: 0301-472X - wos: WOS:000291372500006 (32) - scopus: 2-s2.0-79956274055 (40)

2108/51917 - 2011 - TCTP is a critical survival factor that protects cancer cells from oxidative stress-induced cell-death.
Gambacurta, Alessandra; Rasi, Guido; Garaci, Enrico - 01 - Articolo su rivista
rivista: EXPERIMENTAL CELL RESEARCH (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. - - issn: 0014-4827 - wos: WOS:000295200000010 (39) - scopus: 2-s2.0-80052629994 (48)

2108/51915 - 2011 - Sphingosine kinase 1 overexpression is regulated by signaling through PI3K, AKT2, and mTOR in imatinib-resistant chronic myeloid leukemia cells
Marfe', Gabriella; Gambacurta, Alessandra; Sinibaldi, Paola - 01 - Articolo su rivista
rivista: EXPERIMENTAL HEMATOLOGY (Elsevier Science Incorporated / NY Journals:Madison Square Station, PO Box 882:New York, NY 10159:(212)633-3730, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: (212)633-3680) pp. - - issn: 0301-472X - wos: WOS:000291372500006 (32) - scopus: 2-s2.0-79956274055 (40)

2108/51914 - 2011 - Purification and expansion of stem cells from equine peripheral blood, with clinical applications
Gambacurta, Alessandra - 01 - Articolo su rivista
rivista: VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT (Vlaams Diergeneeskundig Tijdschrift:Salisburylaan 133, B-9820 Merelbeke Belgium:011 32 91 2647513, EMAIL: nadia.eeckhout@rug.ac.be, INTERNET: http://www.allserv.rug.ac.be/~ldevries/start.html, Fax: 011 32 91 2647799) pp. - - issn: 0303-9021 - wos: WOS:000290182400002 (13) - scopus: 2-s2.0-79955822590 (18)

2108/51922 - 2011 - A multicancer-like syndrome in a dog characterized by p53 and cell cycle-checkpoint kinase 2 (CHK2) mutations and Sirtuin gene (SIRT1) down-regulation
Gambacurta, Alessandra - 01 - Articolo su rivista
rivista: RESEARCH IN VETERINARY SCIENCE (Harcourt Publishers Limited:Foots Cray High Street, Sidcup Kent DA14 5HP United Kingdom:011 44 20 83085700, EMAIL: journals@harcourt.com, INTERNET: http://www.harcourt-international.com, Fax: 011 44 20 83085876) pp. - - issn: 0034-5288 - wos: WOS:000305852200045 (10) - scopus: (0)

2108/43733 - 2008 - A new T677C mutation of the aspartoacylase gene encodes for a protein with no enzymatic activity
Gambacurta, Alessandra - 01 - Articolo su rivista
rivista: CLINICAL BIOCHEMISTRY (Elsevier Science Limited: Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 611-615 - issn: 0009-9120 - wos: WOS:000255262300027 (5) - scopus: 2-s2.0-41849137195 (7)

2108/45831 - 2008 - Kit for collecting blood, preferably peripheral blood, for the production of stem cells
Gambacurta, Alessandra - 06 - Brevetti e altre privative registrate

2108/29364 - 2006 - rhEPO (recombinant human eosinophil peroxidase): expression in Pichia pastoris and biochemical characterization
Ciaccio, Chiara; Gambacurta, Alessandra; Petrella, Giuseppe; Coletta, Massimiliano - 01 - Articolo su rivista
rivista: BIOCHEMICAL JOURNAL (London: Portland Press Limited London: Biochemical Society, 1984-) pp. 295-301 - issn: 0264-6021 - wos: WOS:000236840400008 (5) - scopus: 2-s2.0-33645755615 (7)

2108/46072 - 2006 - Metodo di espansione di cellule staminali adulte da sangue periferico e relativi usi in campo medico
Gambacurta, Alessandra - 06 - Brevetti e altre privative registrate

2108/258254 - 2003 - Bovine tryptases. cDNA cloning, tissue specific expression and characterization of the lung isoform
Gambacurta, Alessandra; Fiorucci, Laura; Erba, Fulvio - 01 - Articolo su rivista
rivista: EUROPEAN JOURNAL OF BIOCHEMISTRY (Blackwell Science Limited:PO Box 88, Oxford OX2 0NE United Kingdom:011 44 1865 776868, 011 44 1865 206038, EMAIL: journals.cs@blacksci.co.uk, INTERNET: http://www.blackwell-science.com, Fax: 011 44 1865 721205) pp. 507-517 - issn: 0014-2956 - wos: WOS:000180600700012 (3) - scopus: 2-s2.0-0037315997 (3)

2108/130782 - 1999 - Functional modulation of the Thr72->Ile mutant from Scapharca inaequivalvis homodimeric hemoglobin
Coletta, Massimiliano; Gambacurta, Alessandra; Erba, Fulvio; Polizio, Francesca; Falconi, Mattia - 01 - Articolo su rivista
rivista: JBIC (Germany: Springer Verlag Germany) pp. 678-683 - issn: 0949-8257 - wos: WOS:000084072100002 (3) - scopus: 2-s2.0-0032754453 (3)

2108/130272 - 1998 - Structural and Dynamic Properties of the Homodimeric Hemoglobin from Scapharca inaequivalvis Thr72->Ile Mutant: A molecular dynamics simulation, low temperature visible absorption spectroscopy and resonance Raman spectroscopy studies
Falconi, Mattia; Desideri, Alessandro; Gambacurta, Alessandra - 01 - Articolo su rivista
rivista: BIOPHYSICAL JOURNAL (New York: Published for the Biophysical Society by the Rockefeller University Press) pp. 2489-2503 - issn: 0006-3495 - wos: (0) - scopus: 2-s2.0-0031784910 (7)

2108/258262 - 1996 - cDNA cloning and primary structure of tryptase from bovine mast cells, and evidence for the expression of bovine pancreatic trypsin inhibitor mRNA in the same cells
Gambacurta, Alessandra; Fiorucci, Laura - 01 - Articolo su rivista
rivista: EUROPEAN JOURNAL OF BIOCHEMISTRY (Blackwell Science Limited:PO Box 88, Oxford OX2 0NE United Kingdom:011 44 1865 776868, 011 44 1865 206038, EMAIL: journals.cs@blacksci.co.uk, INTERNET: http://www.blackwell-science.com, Fax: 011 44 1865 721205) pp. 100-105 - issn: 0014-2956 - wos: WOS:A1996UD77400012 (19) - scopus: 2-s2.0-0029670377 (19)

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